Elephant Fiber

Curriculum Vitae Gökhan S. Hotamisligil, M.D., Ph.D.
ADDRESS: Work: Harvard University School of Public Health 665 Huntington Avenue I-205 Boston, MA 02115 (617) 432-1950 (617) 432-1941 (fax) [email protected] http://www.hsph.harvard.edu/GSH-LAB/ EDUCATION: 1980-86 1989-94 Medicine Biological Chemistry and Molecular Pharmacology Ankara University Medical School, Ankara, Turkey Harvard Medical School, Boston, MA M.D. Ph.D. Residence: 26 Halsey Avenue Wellesley, MA 02482 (781) 416-4006 (617) 650-1795 (cell) (781) 235 1549 (fax)

POSTGRADUATE TRAINING: Fellowships: 1988-89 1994-95 Neuro-genetics Cell Biology Harvard Medical School, Boston, MA Harvard Medical School, Boston, MA Research Fellow Postdoctoral Fellow

Internships and Residencies: 1986 1987-88 Pediatrics Pediatrics Royal Hospital for Sick Children, Glasgow, UK Ankara University Medical School, Ankara, Turkey

ACADEMIC APPOINTMENTS: 1995-98 1998-03 20032003200320062007Assistant Professor Associate Professor Professor Professor Chair Associate Member Associate Member Department of Nutrition & Division of Biological Sciences (DBS) Department of Nutrition & DBS Harvard School of Public Health Harvard School of Public Health Department of Nutrition & DBS Harvard School of Public Health Department of Genetics & Complex Harvard School of Diseases & DBS Public Health Department of Genetics & Complex Harvard School of Diseases & DBS Public Health Harvard Stem Cell Institute Harvard University MIT-Harvard Broad Institute Harvard-MIT

HONORS AND DISTINCTIONS: 1989 1991 1994 1996 1997 2003 2003 2004 2004 2005 2006 2007 2007 2008 2008 2008 2008 2008 2009 2010 2010 2010 2010 Harvard University, Division of Medical Sciences Predoctoral Fellowship Lucille P. Markey Predoctoral Fellowship in Developmental Biology American Diabetes Association Postdoctoral Fellowship Career Development Award, American Diabetes Association Pew Scholar in Biomedical Sciences, Pew Charitable Trusts American Asthma Foundation Senior Investigator Award James Stevens Simmons Endowed Professorship in Genetics & Metabolism Elected Member, TUBA, Turkish National Academy of Sciences Recipient of the Scientific and Research Council (TUBITAK) Science Award Chair of the International Stock Symposium on Obesity and Inflammation Lawson Wilkins Lecture of the Pediatric Academic Societies Pfizer Visiting Professorship in Diabetes, University of California, Davis Outstanding Scientific Accomplishment Award of the American Diabetes Association and Lilly Lecture John Denis McGarry Lecture, Montreal Diabetes Research Center Juvenile Diabetes Research Foundation (JDRF) Research Portfolio Advisory Board Member Co-Chair, 13th EASD/JDRF Oxford Workshop: Inflammation, Islets & Immunity Kroc Lecture, University of Washington, Seattle Chair, JDRF Metabolic Control Study Section Elected Fellow of AAAS Judging Committee, Blavatnik Award of the New York Academy of Sciences Turkish Government Ministry of Health Medical Excellence Award Harvard School of Public Health Mentoring Award Wertheimer Award, International Association for the Study of Obesity

PROFESSIONAL SERVICE: School Committees Member, Faculty Search Committee, Cancer Cell Biology, HSPH Chair, HSPH-BPH Graduate Program Retreat Committee Chair, Committee for Edgar Haber Memorial Award Member, BPH Graduate Program Admissions Committee Chair, PhD in Biological Sciences at HSPH, Qualifying Exam and Advisory Committee Member, Division of Biological Sciences Strategic Planning Committee Chair, Faculty Search Committee, Genetics and Complex Diseases Member, Executive Committee of Division of Biological Sciences, HSPH Member, Standing Committee on Appointments, Reappointments and Promotions Chair, Standing Committee on Appointments, Reappointments and Promotions Member, Executive Committee, Genetics and Complex Diseases Roadmap Fellowship Program Member, Faculty Search Committee Genetics & Complex Diseases Chair, Distinguished Seminar Series in the Division of Biological Sciences Member, HSPH Dean Search Committee 1997-1999 1997-2000 1998-2000 1999 1999 2002-2003 2003-2005 2003-present 2007-present 20092005-present 2006-present 2007-present 2008

Chair, Genes and the Environment Steering Committee Chair, Genes and the Environment Initiative at HSPH Director, John Little Center for Genes and Environment Studies Member, Faculty Search Committee, Environmental Epigenetics University Committees Member, Harvard Committee for Recommendations on Material Transfers Member, Clinical Nutrition Research Center at Harvard Member, Harvard University Committee on Patents and Copyrights Member, Harvard Provost Advisory Group on Science Member, Harvard Allston Campus Planning Committee Associate Member, Harvard Stem Cell Institute Member, Harvard Un. Planning Committee for Science & Engineering Associate Member, Harvard-MIT Broad Institute Member, Harvard Human Genetics Advisory Committee Member, Search Committee for Professor of Genetics at MGH/HMS Ad hoc member, Professorial Promotion Committee at HMS Member, Professorial Promotion Committee of Massachusetts General Hospital Member, Professorial Promotion Committee of Beth Israel Deaconess Medical Center External Committees/Services Member, Boston Obesity Nutrition Research Ctr. of Boston Medical Ctr. Member, Boston Area Diabetes Endocrinology Research Center of MGH Member, External Advisory Board of the Columbia DERC Chair, 13th EASD/JDRF Oxford Workshop “Inflammation, Islets, & Immunity” Program Committee, International Diabetes Federation 20th World Congress Medical Science Review Committee, JDRF International Member, JDRF International Board of Advisors European Research Council, Advanced Research Grant Panel Member, NIDDK Diabetes Research Strategic Planning Committee Member, Review Committee, University of Massachusetts Medical School Member, Executive Scientific Committee, Institute on Diabetes and Obesity

2008-present 2008-present 2008-present 2008-2009 1996-1999 1996-present 2000-2001 2002 2004 2006 2006 2007-present 2007-2008 2009 2010 2009 2010

1996-present 1998-present 2006-present 2008 2008 2008 2008-present 2008-present 2008-present 2009 2009

Study Sections and Grant Evaluation Committees, Advisory Boards Wellcome Trust, UK; Diabetes, UK; Comitato Telethon Fondazione Onlus, Italy; Israel Science Foundation; Australian Science Foundation; Dutch Diabetes Research Foundation, and National Institutes of Health, USA; Scientific advisory board of Syndexa Pharmaceuticals Inc, USA; Chair, JDRF Metabolic Control study section, Ad hoc reviewer for Boston Obesity Nutrition Research Center, Harvard Clinical Nutrition Research Center, National Institute for Diabetes and Digestive Diseases. Editorial Reviewer (in alphabetical order): Am. J. Physiol., Cell, Cell Metabolism, Circulation, Developmental Cell, Diabetes, Diabetologia, Endocrinology, EMBO Journal, FASEB J., FEBS Letters, Int. J. Obesity, J. Biol. Chem., J. Clin. Endocrin. Metabolism, J. Clin. Invest., J. Lipid Res., Lancet, Mol. Cell, Mol Pharmacology, Nature, Nature Cell Biology, Nature Genetics, Nature Medicine, New England Journal of Medicine, Obesity Res., PLoS One, PLoS Genetics, PLoS Medicine, Proc. Natl. Acad. Sci. USA, Science Translational Medicine, Science. Editorial Board Member Diabetes, 2001- 2005 Journal of Clinical Investigation, 2005-present Turkish Journal of Biochemistry, 2006-present EMBO Molecular Medicine, 2008-present Journal of Lipid Research, 2009-present Journal of Molecular Medicine, 2009-present

TEACHING EXPERIENCE: Supervisor: Students: * undergraduate 1995 Sung-Joon Lee Sonya Gonzalez Aaron Woolsey Deniz Guler* Ebru Aykan (Erbay) Sam Stampfer Melinda Snitow* Ross Smith Eric Vaillaak Eric Vaillancourt Burcak Civan* Danielle McLaurin Aybike Onur Sanae ElShourbagy Alena Yermalovich Brenna Baccaro Irem Yarali* 1995 Haiyan Xu Judy Tsai Sara Vallerie Khanichi Charles Meric Erikci Ludger Scheja Qiang Tong Kazuhisa Maeda Jiro Hirosumi Genichi Atsumi Qiong Cao Ebru Erbay June Cao Masato Furahashi Carlos Morgan Umut Ozcan Ping Li Abdullah Yalcin Henrik ten Freyhaus Feyza Engin Amir Tirosh Wendy Hernandez Veronica Leautaud Doris Chacon* Derya Shimshek* Miguel Roman-Colon* Pinar Yesil* Kristin Gerhold Raquel Fucho Renin Hazan* Guo Tan Baris Ercal* Jared Mayers Defne Arslan Emily Misch Arielle Bauer Jason Fan Yucel Nalbantoglu* Liza Makowski-Hayes Kathryn Friedinger-Wellen Margaret Gregor Ediz Calay Jaswinder K. Sethi Vidya Muhammed-Ali Xenia Hom Gurol Tuncman Cem Z. Gorgun Haiming Cao Keita Kono Liza Makowski Lale Ozcan Erkan Yilmaz Takahisa Nakamura Ling Yang Suneng Fu Sarah Hummasti Motohiro Sekiya Ana Paula Arruda

Thesis Advisor:

Graduate Advisor: 1995

Exam Committees:

1995

Chun-Yu Chin Xun Wang Rory Geyer Nat Otoo Laura McLaughlin Jennifer Falbe Li Ye

Lijan Wang Kendrin Sonnenville Shannon Reilly Diane Gilbert-Diamond Edward Ruiz Prerna Bhargava Jessica Lucas

Course Instructor: Lecturer Lecturer Director PUBLICATIONS: Original Articles:

1995 1996 1997 -

Harvard School of Public Health Harvard School of Public Health Harvard School of Public Health

BPH 219/DBS205, Seminars in Biological Sciences HSPH 202CD, The Science of Human Nutrition HSPH 204CD/ID512, Mol. Mech. of Nutritional and Metabolic Diseases

1. Hotamisligil GS. Proteus syndrome and neurofibromatosis. Neurofibromatosis 1989, 2:339-240. 2. Hotamisligil GS and Ertogan F. The Proteus syndrome: association with nephrogenic diabetes insipidus. Clin Genet 1990, 38:139-144. 3. Chen Z-Y, Hotamisligil GS, Huang JK, Wen L, Ezzeddine DZ, Aydin-Muderrisoglu N, Powell JF, Huang RH, Breakefield XO, Craig I, Hsu Y-PP. Structure of the human gene for monoamine oxidase type A. Nucl Acid Res 1991, 19:4537-4541. 4. Hotamisligil GS and Breakefield XO. Human monoamine oxidase A gene determines levels of enzyme activity. Am J Hum Genet 1991, 49:383-392. 5. Girmen AS, Baenziger J, Hotamisligil GS, Konradi C, Shalish C, Sullivan JL, Breakefield XO. Relationship between platelet monoamine oxidase B activity and alleles at the MAOB locus. J Neurochem 1992, 59:2063-2066. 6. Hotamisligil GS, Shargill NS, Spiegelman BM. Adipose expression of tumor necrosis factor-!: direct role in obesity-linked insulin resistance. Science 1993, 259:87-91. 7. Spiegelman BM, Hotamisligil GS. Through thick and thin: wasting, obesity and TNF-!. Cell 1993, 73:625-627. 8. Hotamisligil GS, Girmen AS, Fink S, Tivol E, Shalish C, Tofatter J, Baenziger J, Diamond S, Markham C, Sullivan J, Growdon J, Breakefield XO. Hereditary variations in monoamine oxidase as a risk factor for Parkinson’s disease. Movement Disorders 1994, 9:305-310.

9. Hofmann C, Lorenz K, Braithwaite SS, Colca JR, Palazuk BJ, Hotamisligil GS, Spiegelman BM. Altered gene expression for TNF-! and its receptors during drug and dietary modulation of insulin resistance. Endocrinology 1994, 134:264-270. 10. Hotamisligil GS, Budavari A, Murray DL, Spiegelman BM. Reduced tyrosine kinase activity of the insulin receptor in obesity-diabetes. Central role of tumor necrosis factor-!. J Clin Invest 1994, 94:1543-1549. 11. Hotamisligil GS, Murray DL, Choy LN, Spiegelman BM. Tumor necrosis factor-! inhibits signaling from the insulin receptor. Proc Natl Acad Sci USA 1994, 91:4854-4858. 12. Hotamisligil GS, Arner P, Caro JF, Atkinson RL, Spiegelman BM. Increased adipose tissue expression of TNF-! in human obesity and insulin resistance. J Clin Invest 1995, 95:24092415. 13. Peraldi P, Hotamisligil GS, Buurman WA, White MF, Spiegelman BM. Tumor necrosis factor-! inhibits insulin signaling through stimulation of p55 TNF receptor and activation of sphingomyelinase. J Biol Chem 1996, 271:13018-13022. 14. Hotamisligil GS, Johnson RS, Distel RJ, Ellis R, Papaioannou VE, Spiegelman BM. Uncoupling of obesity from insulin resistance through a targeted mutation in aP2, the adipocyte fatty acid binding protein. Science 1996, 274:1377-1379. 15. Hotamisligil GS, Peraldi P, Budavari A, Ellis R, White MF, Spiegelman BM. IRS-1mediated inhibition of insulin receptor tyrosine kinase activity in TNF! and obesity-induced insulin resistance. Science 1996, 271:665-668. 16. Hotamisligil GS, Arner P, Atkinson RL, Spiegelman BM. Differential regulation of p80 tumor necrosis factor receptor in human obesity and insulin resistance. Diabetes 1997, 46:451-455. 17. Kirchgessner TG, Uysal KT, Weisbrock S, Marino M, Hotamisligil GS. Tumor necrosis factor-! contributes to obesity-related hyperleptinemia by regulating leptin release from adipocytes. J Clin Invest 1997, 100:2777-2782. 18. Uysal KT, Wiesbrock SM, Marino MW, Hotamisligil GS. Protection from obesity-induced insulin resistance in mice lacking TNF-! function. Nature 1997, 389:610-614. 19. Uysal KT, Wiesbrock SM, Hotamisligil GS. Functional analysis of TNF receptors in TNF-!mediated insulin resistance in genetic obesity. Endocrinology 1998, 139:4832-4838. 20. Chu N-F, Makowski L, Hotamisligil GS, Rimm EB. Stability of human plasma leptin concentrations within 36 hours following specimen collection. J Clin Biochem 1999, 32:8789. 21. Samad F, Uysal KT, Wiesbrock SM, Pandey M, Hotamisligil GS, Loskutoff DJ. Tumor necrosis factor-! is a key component in the obesity-linked elevation of plasminogen activator inhibitor-1. Proc Natl Acad Sci USA 1999, 96:6902-6907.

22. Scheja L, Makowski L, Uysal KT, Wiesbrock SM, Shimshek D, Parker RA Hotamisligil GS. Altered insulin secretion associated with reduced lipolytic efficiency in aP2-deficient mice. Diabetes 1999, 48:1987-1994. 23. Xu H, Sethi JK, Hotamisligil GS. Transmembrane tumor necrosis factor (TNF-!) inhibits adipocyte differentiation by selectively activating TNF receptor 1. J Biol Chem 1999, 274:26287-26295. 24. Sethi JK, Xu H, Uysal KT, Wiesbrock SM, Scheja L, Hotamisligil GS. Characterisation of receptor-specific TNF-! functions in adipocyte cell lines lacking type 1 and 2 TNF receptors. FEBS Letters 2000, 469:77-82. 25. Memon RA, Hotamisligil GS, Wiesbrock SM, Uysal KT, Faggioni R, Moser AH, Feingold KR, Grunfeld C. Upregulation of uncoupling protein 2 mRNA in genetic obesity: lack of an essential role from leptin, hyperphagia, increased tissue lipid content, and TNF-!. Biochem Biophys Acta 2000, 1484:41-50. 26. Nisoli E, Briscini L, Giordano A, Tonello C, Wiesbrock SM, Uysal KT, Cinti S, Carruba MO, Hotamisligil GS. Tumor necrosis factor-! mediates apoptosis of brown adipocytes and defective brown adipocyte function in obesity. Proc Natl Acad Sci USA 2000, 97:80338038. 27. Chu, NF, Spiegelman D, Rifai, N, Hotamisligil GS, Rimm EB. Glycemic status and soluble tumor necrosis factor receptor levels in relation to plasma leptin concentrations among normal and overweight US men. Int J Obes Relat Metab Disord 2000, 24:1085-1092. 28. Uysal KT, Scheja L, Wiesbrock SM, Bonner-Weir S, Hotamisligil GS. Improved glucose and lipid metabolism in genetically obese mice lacking aP2. Endocrinology 2000, 141:3388-3396. 29. Tong Q, Dalgin G, Xu H, Ting C-N, Leiden JM, Hotamisligil GS. Function of GATA transcription factors in preadipocyte-adipocyte transition. Science 2000, 290:134-138. 30. Chu NF, Stampfer MJ, Spiegelman D, Rifai N, Hotamisligil GS, Rimm EB. Dietary and lifestyle factors in relation to plasma leptin concentrations among normal weight and overweight men. Int J Obesity 2001, 25:106-114. 31. Makowski L, Boord JB, Maeda K, Babaev VR, Uysal KT, Morgan MA, Parker R, Suttles J, Fazio S, Hotamisligil GS, Linton MF. Lack of macrophage fatty-acid-binding protein aP2 protects mice deficient in apolipoprotein E against atherosclerosis. Nature Medicine 2001, 7:699-705. 32. Chu NF, Spiegelman D, Hotamisligil GS, Rifai N, Stampfer M, Rimm EB. Plasma insulin, leptin, and soluble TNF receptor levels in relation to atherogenic and thrombogenic cardiovascular disease risk factors among men. Atherosclerosis 2001, 157:495-503. 33. Chu NF, Spiegelman D, Hotamisligil GS, Rifai N, Rimm EB. Plasma leptin concentrations and 4-year weight gain among US men. Int J Obesity 2001, 25:346-353.

34. Way JM, Gorgun CZ, Tong Q, Uysal KT, Brown KK, Harrington WW, Oliver WR Jr, Willson TM, Kliewer SA, Hotamisligil GS. Adipose tissue resistin expression is severely suppressed in obesity and stimulated by PPAR" agonists. J Biol Chem 2001, 276:2565125653. 35. Xu H and Hotamisligil GS. Signaling pathways utilized by tumor necrosis factor receptor 1 in adipocytes to suppress differentiation. FEBS Letters 2001, 506:97-102. 36. Fisher RM, Eriksson P, Hoffstedt J, Hotamisligil GS, Thorne A, Ryden M, Hamsten A, Arner P. Fatty acid binding protein expression in different human adipose tissue depots from lean and obese individuals. Diabetologia 2001, 44:1268-1273. 37. Mohamed-Ali V, Flower L, Sethi J, Hotamisligil GS, Gray R, Humphries SE, York DA, Pinkney J. ß-adrenergic regulation of IL-6 release from adipose tissue: in vivo and in vitro studies. J Clin Endocrinol Metab 2001, 86:5864-5869. 38. Emanuelli B, Peraldi P, Filloux C, Chavey C, Freidinger K, Hilton DJ, Hotamisligil GS, Van Obberghen E. SOCS-3 inhibits insulin signaling and is up-regulated in response to TNF-! in the adipose tissue of obese mice. J Biol Chem 2001, 276:47944-47949. 39. Chiellini C, Bertacca A, Gorgun CZ, Ciccarone A, Giordano A, Xu H, Soukas A, Costa M, Gandini D, Dimitri R, Bottone P, Cecchetti P, Pardini E, Perego L, Navalesi R, Folli F, Benzi L, Cinti S, Friedman JM, Hotamisligil GS, Maffei M. Obesity modulates the expression of haptoglobulin in white adipose tissue via TNF-!. J Cell Physiol 2002, 190:251-258. 40. Fisher RM, Hoffstedt J, Hotamisligil GS, Thorne A, Ryden M. Effects of obesity and weight loss on the expression of proteins involved in fatty acid metabolism in human adipose tissue. Intl J Obes Relat Metab Disord 2002, 26:1379-1385. 41. Xu H, Hirosumi J, Uysal KT, Guler AD, Hotamisligil GS. Exclusive action of transmembrane TNF-! in adipose tissue leads to reduced adipose mass and local but not systemic insulin resistance. Endocrinology 2002, 143:502-511. 42. Xu H, Uysal KT, Becherer D, Arner P, Hotamisligil GS. Altered tumor necrosis factor-! (TNF-!) processing in adipocytes and increased expression of transmembrane TNF-! in obesity. Diabetes 2002, 51:1876-1883. 43. Boord JB, Maeda K, Makowski L, Babaev VR, Fazio S, Linton MF, Hotamisligil GS. Adipocyte fatty acid binding protein, aP2, alters later atherosclerotic lesion formation in severe hypercholesterolemia. Art Thro Vasc Bio 2002, 22:1686-1691. 44. Hirosumi J, Tuncman G, Chang L, Gorgun CZ, Uysal KT, Maeda K, Karin M, Hotamisligil GS. A central role for JNK in obesity and insulin resistance. Nature 2002, 420:333-336. 45. Maeda K, Uysal KT, Makowski L, Gorgun CZ, Atsumi G, Parker RA, Bruning J, Hertzel AV, Bernlohr DA, Hotamisligil GS. Role of the fatty acid-binding protein mal1 in obesity and insulin resistance. Diabetes 2003, 52:300-307. 46. Pandey M, Tuncman G, Hotamisligil GS, Samad F. Divergent roles for p55 & p75 TNF-! receptors in the induction of plasminogen activator inhibitor-1. Am J Phys 2003, 162:933941.

47. Pischon T, Hotamisligil GS, Rimm EB. Adiponectin: stability in plasma over 36 hours and within-person variation over 1 year. J Clin Biochem 2003, 49:650-652. 48. Tong Q, Sankalé J-L, Hadigan CM, Tan G, Rosenberg ES, Kanki PJ, Grinspoon SK, Hotamisligil GS. Regulation of adiponectin in human immunodeficincy virus infected patients: relationship to body composition and metabolic indices. J Clin Endocrinol Metabol 2003, 88:1559-1564. 49. Pischon T, Hankinson SE, Hotamisligil GS, Rifai N, Willett WC, Rimm EB. Habitual dietary intake of n-3 and n-6-fatty acids in relation to inflammatory markers among US men and women. Circulation 2003, 108:155-160. 50. Pischon T, Hankinson SE, Hotamisligil GS, Rifai N, Rimm EB. Leisure-time physical activity and reduced plasma levels of obesity-related inflammatory markers. Obes Res 2003, 11:1055-1064. 51. Pischon T, Girman C, Hotamisligil GS, Rifai N, Hu FB, Rimm E. Plasma adiponectin levels and risk of myocardial infarction in men. JAMA 2004, 291:1730-1737. 52. Wellen KE, Uysal KT, Wiesbrock S, Yang Q, Chen H, Hotamisligil GS. Interaction of TNF! and thiazolidinedione-regulated pathways in obesity. Endocrinology 2004,145:22142220. 53. Boord JB, Maeda K, Makowski L, Babaev VR, Fazio S, Linton MF, Hotamisligil GS. Combined fatty acid-binding protein deficiency improves metabolism, reduces atherosclerosis, and increases survival in apolipoprotein E-deficient mice. Circulation 2004, 110:1492-1498. 54. Ozcan U, Cao Q, Yilmaz E, Lee AH, Iwakoshi NN, Ozdelen E, Tuncman G, Glimcher L, Hotamisligil, GS. Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science 2004, 306:457-461. 55. Pischon T, Girman CJ, Rifai N, Hotamisligil GS, Rimm EB. Association between dietary factors and plasma adiponectin concentration in men. Am J Clin Nutr 2005, 81:780-786. 56. Tong Q, Tsai J, Tan G, Dalgin G, Hotamisligil GS. Interaction between GATA and C/EBP family of transcription factors is critical in GATA-mediated suppression of adipocyte differentiation. Mol Cell Bio 2005, 25:706-715. 57. Makowski L, Brittingham KC, Reynolds JM, Suttles J, Hotamisligil GS. The fatty acidbinding protein, aP2, coordinates macrophage cholesterol trafficking and inflammatory activity. J Biol Chem 2005, 280:12888-12895. 58. Maeda K, Cao H, Kono K, Gorgun CZ, Furuhashi M, Uysal KT, Cao Q, Atsumi G, Malone H, Krishnan B, Minokoshi Y, Kahn BB, Parker RA, Hotamisligil GS. Adipocyte/macrophage fatty acid-binding proteins control integrated metabolic responses in obesity and diabetes. Cell Met 2005, 1:107-119. 59. Tsai J, Tong Q, Tan G, Chang AN, Orkin SH, Hotamisligil GS. The transcription factor GATA2 regulates differentiation of brown adipocytes. EMBO Reports 2005, 6:879-884.

60. Neels JG, Pandey M, Hotamisligil GS, Samad F. Autoamplification of tumor necrosis factoralpha: a potential mechanism for the maintenance of elevated tumor necrosis factor-alpha in male but not female obese mice. Am J Pathol 2006, 168:435-444. 61. Sankale J-LG, Tong Q, Hadigan CM, Tan G, Grinspoon SK, Kanki PJ, Hotamisligil, GS. Regulation of adiponectin in adipocytes upon exposure to HIV-1. HIV Medicine 2006, 7:268-274. 62. Baumgartl J, Baudler S, Scherner M, Babaev V, Makowski L, Suttles J, McDuffie M, Tobe K, Kadowaki T, Fazio S, Kahn CR, Hotamisligil GS, Krone W, Linton M, Bruning JC. Myeloid lineage cell-restricted insulin resistance protects apolipoproteinE-deficient mice against atherosclerosis. Cell Met 2006, 3:247-256. 63. Tuncman G, Erbay E, Hom X, De Vivo I, Campos H, Rimm EB, Hotamisligil GS. A genetic variant at the fatty acid-binding protein aP2 locus reduces the risk for hypertriglyceridemia, type 2 diabetes, and cardiovascular disease. Proc Natl Acad Sci USA 2006, 103:6970-6975. 64. Tuncman G, Hirosumi J, Solinas G, Chang L, Karin M, Hotamisligil GS. Functional in vivo interactions between JNK1 and JNK2 isoforms in obesity and insulin resistance. Proc Natl Acad Sci USA 2006, 103:10741-10746. 65. Cao H, Maeda K, Gorgun CZ, Kim HJ, Park SY, Shulman GI, Kim JK, Hotamisligil GS. Regulation of metabolic responses by adipocyte/macrophage fatty acid-binding proteins in leptin-deficient mice. Diabetes 2006, 55:1915-1922. 66. Bence KK, Delibegovic M, Xue B, Gorgun CZ, Hotamisligil GS, Neel BG, Kahn BB. Neuronal PTP1B regulates body weight, adiposity and leptin action. Nature Medicine 2006, 12:917-924. 67. Shum B, Mackay CR, Gorgun CZ, Frost MJ, Kumar RK, Hotamisligil GS, Rolph MS. The adipocyte fatty acid-binding protein aP2 is required in allergic airway inflammation. J Clin Invest 2006, 116:2183-2192. 68. Witczak CA, Hirshman MF, Jessen N, Fujii N, Seifert MM, Brandauer J, Hotamisligil GS, Goodyear JL. JNK1 deficiency does not enhance muscle glucose metabolism in lean mice. Biochem Biophys Res Commun 2006, 350:1063-1068. 69. Ozcan U, Yilmaz E, Ozcan L, Furuhashi M, Vaillancourt E, Smith RO, Gorgun CZ, Hotamisligil GS. Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes. Science 2006, 313:1137-1140. 70. Rolph MS, Young TR, Shum BO, Gorgun CZ, Schmitz-Peiffer C, Ramshaw IA, Hotamisligil GS, Mackay CR. Regulation of dendritic cell function and T cell priming by the fatty acidbinding protein aP2. J. Immunol 2006, 177:7794-801. 71. Steinberg GR, Michell BJ, van Denderen BJ, Watt MJ, Carey AL, Fam BC, Andrikopoulos S, Proietto J, Gorgun CZ, Carling D, Hotamisligil GS, Febbraio MA, Kay TW, Kemp BE. Tumor necrosis factor-! a-nd induced skeletal muscle insulin resistance involves the suppression of AMP-kinase signaling. Cell Met 2006, 4:465-474.

72. Song Y, Manson JE, Tinker L, Rifai N, Cook NR, Hu FB, Hotamisligil GS, Ridker PM, Rodriguez BL, Margolis KL, Oberman A, Liu S. Circulating levels of endothelial adhesion molecules and risk of diabetes mellitus in an ethnically diverse cohort of women. Diabetes 2007, 56:1898-18904. 73. Wellen K, Fucho R, Gregor MF, Furuhashi M, Morgan C, Lindstad T, Vaillancourt E, Gorgun CZ, Saatcioglu F, Hotamisligil GS. Coordinated regulation of nutrient and inflammatory responses by STAMP2 is essential for metabolic homeostasis. Cell 2007, 129:537-548. 74. Furuhashi M, Tuncman G, Gorgun CZ, Makowski L, Atsumi G, Vaillancourt E, Kono K, Babaev VR, Fazio S, Linton MF, Sulsky R, Robl JA, Parker RA, Hotamisligil GS. Treatment of diabetes and atherosclerosis by inhibiting fatty acid-binding protein aP2. Nature 2007, 447:959-965. 75. Reynolds JM, Liu Q, Brittingham KC, Liu Y, Gruenthal M, Gorgun CZ, Hotamisligil GS, Stout RD, Suttles J. Deficiency of fatty acid-binding proteins in mice confers protection from development of experimental autoimmune encephalomyelitis. J Immunol 2007, 179:313-321. 76. Liu S, Tinker L, Song Y, Rifai N, Bonds D, Cook NR, Heiss G, Howard B, Hotamisligil GS, Hu FB, Kuller L, Manson JE. A prospective study of inflammatory cytokines and diabetes mellitus in a multiethnic cohort of postmenopausal women. Arch Int Med 2007, 167:1676-1685. 77. Ozcan U, Ozcan L, Yilmaz E, Duvel K, Sahin M, Manning BD, Hotamisligil GS. Loss of the tuberous sclerosis complex tumor suppressors triggers the unfolded protein response to regulate insulin signaling and apoptosis. Mol Cell 2008, 29:541-551. 78. Furuhashi M, Fucho R, Gorgun C, Tuncman G, Cao H, Hotamisligil GS. Adipocyte/macrophage fatty acid-binding proteins contribute to metabolic deterioration through actions in both macrophages and adipocytes in mice. J Clin Invest 2008, 118:26402650. 79. Vallerie SN, Furuhashi M, Fucho R, Hotamisligil GS. A predominant role of JNK activity in the stromal elements in regulating systemic insulin sensitivity. PLoS 2008 3:1-11. 80. Cao H, Gerhold K, Wiest MW, Watkins SM, Hotamisligil GS. Identification of a lipokine, a lipid hormone linking adipose tissue to systemic metabolism. Cell 2008, 134:933-944. 81. Gregor MF, Yang L, Fabbrini E, Mohammed BS, Eagon JC, Hotamisligil GS, Klein S. Endoplasmic reticulum stress is reduced in tissues of obese subjects after weight loss. Diabetes 2009, 58:693-700. 82. Chavey C, Lazennec G, Lagarrigue S, Clapé1 C, Iankoval I, Teyssier J, Annicotte J-S, Schmidt J, Mataki C, Yamamoto H, Sanches R, Guma A, Stich V, Vitkova M, JardinWatelet B, Renard E, Strieter R, Tuthill A, Hotamisligil GS, Vidal-Puig T, Zorzano A, Langin D, Fajas L. CXCL5 is an adipose tissue derived factor that links obesity to insulin resistance. Cell Met 2009, 4:339-349.

83. Liu J, Divoux A, Sun J, Zhang J, Clément K, Glickman JN, Sukhova GK, Wolters PJ, Du J, Gorgun CZ, Doria A, Libby P, Blumberg RS, Kahn BB, Hotamisligil GS, Shi G-P. Deficiency and pharmacological stabilization of mast cells reduces diet-induced obesity and diabetes in mice. Nat Med 2009, 8:940-945. 84. Erbay E, Babaev VR, Mayers JR, Makowski L, Charles KN, Snitow M, Fazio S, Wiest MM, Watkins SM, Linton MF, Hotamisligil GS. Reducing endoplasmic reticulum stress through a macrophage lipid chaperone alleviates atherosclerosis. Nat Med 2009, 12:1383-1391. 85. Nakamura T, Furuhashi M, Li P, Cao H, Tuncman G, Sonenberg N, Gorgun CZ, Hotamisligil GS. Double-stranded RNA-dependent protein kinase links pathogen sensing with stress and metabolic homeostasis. Cell 2010, 140:338-348. 86. Yang L, Li P, Fu S, Calay ES, Hotamisligil GS. Defective hepatic autophagy in obesity causes insulin resistance. Cell Met 2010, 11:467-478. 87. Kars M, Yang L, Gregor MF, Mohammed BS, Pietka TA, Finck BN, Patterson BW, Horton JD, Mittendorfer B, Hotamisligil GS, Klein S. Tauroursodeoxycholic acid improves may improve liver and muscle but not adipose tissue insulin sensitivity in obese men and women. Diabetes 2010, 59:1899-1905. Books, Chapters and Reviews: 1. Hotamisligil GS. Proteus syndrome and neurofibromatosis. Neurofibromatosis 1989, 2:339-340. 2. Hotamisligil GS. Proteus syndrome and hamartoses with overgrowth. Dysmorphol Clin Genet 1990, 4:87-102. 3. Spiegelman BM, Choy LN, Hotamisligil GS, Graves RA, Tontonoz P. Regulation of adipocyte gene expression in differentiation and syndromes of obesity/diabetes. J Biol Chem 1993, 268:6823-6826. 4. Spiegelman BM, Hotamisligil GS. Through thick and thin: wasting, obesity, and TNF-!. Cell 1993, 73:625-627. 5. Hotamisligil GS and Spiegelman BM. TNF-!: a key component of the obesity-diabetes link. Diabetes 1994, 43:1271-1278. 6. Hotamisligil GS, Peraldi P, Spiegelman BM. The molecular link between obesity and diabetes. Curr Opin Endocrinol Diabetes 1996, 16-23. 7. Hotamisligil GS, Spiegelman BM. Mechanisms of TNF-!-mediated insulin resistance: inhibition of insulin receptor tyrosine kinase. In Molecular and Genetic Aspects of Obesity: Bray GA, Ryan DH, eds., Louisiana State University Press, Baton Rouge, 1996, 205-216. 8. Hotamisligil GS, Spiegelman BM. TNF-! and the insulin resistance of obesity. In Diabetes Mellitus: LeRoith D, Taylor SI, Olefsky JM, eds., Lippincott-Raven Publishers, Philadelphia, 1993, 554-560.

9. Hotamisligil GS. The cross-talk between insulin and tumor necrosis factor receptors in insulin resistance. Endocrinol Metabol 1997, 4:151-153. 10. Hotamisligil GS. Mechanisms of TNF-!-induced insulin resistance. Exp Clin Endocrinol Diabetes 1999, 107:119-125. 11. Hotamisligil GS. The role of TNF-! and TNF receptors in obesity and insulin resistance. J Intern Med 1999, 245:621-625. 12. Sethi JK, Hotamisligil GS. The role of TNF-! in adipocyte metabolism. Cell Development Biology 1999, 10:19-29. 13. Hotamisligil GS, Spiegelman BM. TNF! and the insulin resistance of obesity. In Diabetes Mellitus: a fundamental and clinical text. LeRoith D, Taylor SI, Olefsky JM, eds., Lippincott-Raven Publishers, Philadelphia, 2000, 651-659. 14. Hotamisligil GS. Molecular mechanisms of insulin resistance and the role of the adipocyte. Int J Obes 2000, Suppl 4:S23-7. 15. Tong Q, Hotamisligil GS. Molecular mechanisms of adipocyte differentiation. Reviews in Endocrine Met Disorders 2001, 2:349-355. 16. Abumrad NA, Hotamisligil GS. Command centers for metabolic control can be in the most unexpected places. Curr Opin Clin Nutr Metab Care 2002, 5:357-358. 17. Hotamisligil GS. Inflammation, tumor necrosis factor-!, and insulin resistance. In LeRoith, D, Taylor SI, Olefsky, JM, eds. In Diabetes Mellitus: a fundamental and clinical text. 3rd ed. Philadelphia: Lippincott Williams & Wilkins, 2003, Chapter 64:953-962. 18. Hotamisligil GS. The irresistible biology of resistin. J Clin Invest 2003, 111:173-174. 19. Tong Q, Tsai J, Hotamisligil GS. GATA Transcription factors and fat cell formation. Drug News & Perspectives 2003, 16:585-588. 20. Wellen KE, Hotamisligil GS. Obesity-induced inflammatory changes in adipose tissue. J Clin Invest, 2003, 112:1785-1788. 21. Hotamisligil GS. Inflammatory pathways and insulin action. Int J Obes Relat Metab Disord 2003, suppl 3:S53-55. 22. Makowski L, Hotamisligil GS. Fatty acid-binding proteins- the evolutionary crossroads of inflammatory and metabolic responses. J of Nutrition 2004, 134(9):2464S-68S. 23. Wellen KE, Hotamisligil GS. Inflammation, stress, and diabetes. J Clin Invest 2005, 115:1111-1119. 24. Makowski L, Hotamisligil GS. The role of fatty acid-binding proteins in atherosclerosis. Curr Opin Lipidology 2005, 16:543-548. 25. Tsai J, Tong Q, Hotamisligil GS. GATA proteins as molecular gatekeepers of adipogenesis. In New Transcription Factors and their Roles in Diabetes and its Therapy: Friedman, J.E., eds., Elsevier Science B.V. Publishers, 2006.

26. Hotamisligil, GS. Role of endoplasmic reticulum stress and c-Jun NH2-terminal kinase pathways in inflammation and origin of obesity and diabetes. Diabetes 2005, 54:S73-S78. 27. Tilg H, Hotamisligil GS. Nonalcoholic fatty liver disease: cytokine-adipokine interplay and regulation of insulin resistance. Gastroenterology 2006, 131:934-945. 28. Hotamisligil GS. Inflammation and metabolic disorders. Nature 2006, 444:860-867. 29. Tong Q, Hotamisligil GS. Cell fate in the mammary gland. Nature 2007, 445:724-726. 30. Gregor MF, Hotamisligil GS. Adipocyte stress: the endoplasmic reticulum and metabolic disease. J Lipid Res 2007, 48:1905-1914. 31. Erbay E, Cao H, Hotamisligil GS. Adipocyte/macrophage fatty acid-binding proteins in metabolic syndrome. Curr Atheroscler Rep 2007, 9:222-229. 32. Furuhashi M, Hotamisligil GS. Regulation of metabolic homeostasis through a family of fatty acid-binding proteins. Nat Rev Drug Discov 2008, 7:489-503. 33. Erbay E, Hotamisligil GS. Nutrient sensing and inflammation in metabolic diseases. Nat Rev Immunol 2008, 8:923-934. 34. Yang L, Hotamisligil GS. Stressing the brain, fattening the body. Cell 2008, 135:20-22. 35. Hotamisligil GS. Inflammation and endoplasmic reticulum stress in obesity and diabetes. Int J Obes 2008, S52-S54. 36. Hotamisligil GS. Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. Cell 2010, 140(6):900-917. 37. Hotamisligil GS. Endoplasmic reticulum stress and atherosclerosis. Nat Med 2010, 16(4):396-399. 38. Li P, Hotamisligil GS. Host and microbes in a pickle. Nature 2010, 464:1287-88. 39. Hummasti S, Hotamisligil GS. Endoplasmic Reticulum Stress and Inflammation in Obesity and Diabetes. Circ Res 2010, 107: 579-591. 40. Engin F, Hotamisligil, GS. Restoring ER function by chemical chaperones: An emerging therapeutic approach for metabolic diseases. In press.

INVITED LECTURES: Local and National: • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • Yale University, Genetics Seminar, November 2010, New Haven, CT. PEW Scholars 25th Reunion, November 2010, Duck Key, FL. 12th Annual Frontiers in Diabetes Research Meeting, November 2010, New York, NY. 16th International Conference of the Inflammation Research Association, September 2010, Chantilly, VA. Plenary Lecture, 10th Anniversary UCSF Diabetes Center Symposium, September 2010, San Francisco, CA. 2010 Cold Spring Harbor Laboratory Meeting on Nuclear Receptors & Disease, August 2010, Long Island, NY. American Diabetes Association’s 70th Scientific Sessions, June 2010, Orlando, FL. Plenary Lecture, Endocrine Society Meeting, June 2010, San Diego, CA. Kroc Lecture at the University of Alabama, April 2010, Birmingham, AL. Annual Wyeth Discovery Frontiers in Human Disease, March 2010, New York, NY. Distinguished Lecture Series of Eli Lilly and Company, February 2010, Indianapolis, IN. University of Pennsylvania, Department of Pharmacology, ITMAT Seminar Series, January 2010, Philadelphia, PA. 8th Bi-Annual meeting: International Chair on Cardiometabolic Risk, October 2009, Boston, MA. 4th Annual Frontiers of Clinical Investigation: Bench to Bedside Symposium, October 2009, La Jolla at Torrey Pines, CA. FASEB Summer Research Conference, June 2009, Saxon’s River, VT. Visiting Professor, University of Michigan, May 2009, Ann Arbor, MI. NIH, NIDDK meeting, “Interface Between Metabolic Disturbances and Alterations of the Immune System, May 2009, Bethesda, MD. Endocrine Grand Rounds, Boston University, February 2009, Boston, MA. NIH, NIDDK workshop “Protein Mis-folding and Mis-processing in Disease” January 2009, Bethesda, MD. Dean’s Distinguished Seminar Series, University Colorado School of Medicine, Jan 2009, Aurora, CO. Endocrine Grand Rounds, Brigham and Women’s Hospital, January 2009, Boston, MA. Research Affinity Group on Cell and Gene Therapy, Children’s Hospital Philadelphia, Dec 2008, Philadelphia, PA. Skirball Symposium, Skirball Institute, NYU, November 2008, New York, NY. Yale University, Depts. of Physiology & Pharmacology, October 2008, New Haven, CT Merck Expert Forum, May 2008, Rahway, NJ. Joslin Diabetes Research Center, May 2008, Boston, MA. Harvard School of Public Health, Department of Nutrition, April 2008, Boston, MA. ASBMB, April 2008, San Diego, CA. Endocrine Grand Rounds, Beth Israel Medical Deaconess Center, March 2008, Boston, MA. Baylor College of Medicine, March 2008, Houston, TX. Kroc Scholar Lecture, University of Washington, March 2008, Seattle, WA. Schering Plough, March 2008, Rahway, NJ.

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Pennington Biomedical Research Center, Louisiana State University, March 2008, Baton Rouge, LS. Keystone Symposia, January 2008, Breckenridge, CO. Endocrine Grand Rounds, Massachusetts General Hospital, October 2007, Boston, MA. Pfizer Visiting Professorship in Diabetes, UC Davis, October 2007, Davis, CA. Schering Plough, September 2007, Cambridge MA. Cardiometabolic Health Congress, September 2007, Boston, MA. Invited speaker, Rhode Island Hospital/Brown Medical School, September 2007, Providence, RI. Nathan W. Shock Aging Symposium, National Institutes of Aging, September 2007, Towson MD. Invited speaker, University of Alabama, September 2007, Birmingham, AL. Lilly Lecture, Annual American Diabetes Association meeting, June 2007, Chicago, IL. Massachusetts Dietetic Association, April 2007, Marlborough, MA. Keystone Symposia, March 2007, Steamboat Springs, CO. Keynote address, Harvard Medical School, 9th Annual Postgraduate Nutrition Symposium: Obesity and Inflammation, March 2007, Boston, MA. “When is Amyloid Functional and When is Amyloidogenesis Pathogical?” The Banbury Center, Cold Spring Harbor Laboratory, March 2007, Cold Spring Harbor, NY. Invited Speaker, Washington University, February 2007 St. Louis, MO. Harvard School of Public Health Leadership Council, October 2006, Boston, MA Invited speaker, American Diabetes Association 66th Annual Scientific Session, June 2006, Washington DC. Sandler Program for Asthma Research Annual Meeting, May 2006, San Francisco, CA. American Heart Association/American Diabetes Association Symposium on Metabolic Syndrome/Metabolic Risks: Implications, May 2006, San Francisco, CA. Lawson Wilkins Lecture, Pediatric Academic Societies Annual Meeting, May 2006, San Francisco, CA. HealthCare Ventures’ Scientific Advisory Retreat, March 2006, West Palm Beach, FL. 8th Annual Postgraduate Nutrition Symposium, “Metabolic Syndrome and Onset of Cancer,” March 2006, Boston, MA. Invited speaker, NIH, NIDDK, September 2005, Bethesda, MD. American Diabetes Association 65th Scientific Sessions, June 2005, San Diego, CA. Cystic Fibrosis Foundation Williamsburg Meeting, June 2005, Williamsburg, VA. Sandler Program for Asthma Research Annual Meeting, May 2005, San Francisco, CA. 2005 Keystone Conference on Diabetes Mellitus: Molecular Mechanisms, Genetics and New Therapies, February 2005, Keystone, CO. Martek Biosciences Forum: The Role of Inflammation in Chronic Disease, January 2005, Boulder, CO. Living Well to 100, Tufts University, November 2004, Boston, MA. Second Annual Leadership Council Meeting, Harvard School of Public Health, October 2004, Boston, MA. Columbia University’s Division of Endocrinology Friday Seminar Series, October 2004, New York, NY. NIH National Institute on Aging Workshop "Inflammation, Inflammatory Cytokines, and Aging," September 2004, Bethesda, MD. Sandler Program for Asthma Research Annual Meeting, May 2004, San Francisco, CA. The Center for Bits and Atoms Colloquium, MIT, April 2004, Cambridge, MA.

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Univ. of Pennsylvania’s Distinguished Lecture Series, January 2004, Philadelphia, PA. NIH Adipose Tissue Secretory Function Symposium, December 2003, Washington DC. Harvard School of Public Health, Inaugural Leadership Council Meeting, October 2003, Boston, MA. Distinguished Lecture Series of Eli Lilly and Company, June 2003, Indianapolis, IN. Molecular Endocrinology-Metabolic Disorders-Diabetes Series of Merck & Co., April 2003, Rahway, NJ. NIH National Institute on Aging Distinguished Lecture Series at the Gerontology Research Center, April 2003, Baltimore, MD. Harvard Medical Center Symposium at the Medical Education Center, March 2003, Boston, MA. Endocrinology Grand Rounds, Beth Israel Deaconness Hosp., March 2003, Boston, MA. Children’s Hospital Endocrine Division Seminars, December 2002, Boston, MA. Insulin Action, Insulin Resistance, Inflammation and Atherosclerosis Symposium, September 2002, Niagara Falls, NY. AASLD Conference on Nonalcoholic Steatohepatitis, September 2002, Atlanta, GA. Biochemistry Pharmacology Discussion Group at the New York Academy of Sciences: Modulating Obesity, Diabetes, and Cardiovascular diseases with PPAR Ligands. September 2002, New York, NY. Bristol-Meyers Squibb Pharmaceutical Research Institute Seminar, September 2002, Hopewell, NJ. Aspen Lipid Conference: Lipid Transport, August 2002, Aspen, CO. The Critical Role of Overlapping Pathways in Adipocyte and Macrophages in Metabolic Syndrome, Abbott Global Pharmaceutical Research and Development, June 2002, Chicago, IL. University of Florida, Seminar Series of the Interdisciplinary Program at the College of Medicine, February 2002, Gainesville, FL. Keystone Symposia: Molecular Control of Adipogenesis and Obesity/Diabetes Mellitus. Molecular Mechanisms and Genetics, January 2002, Colorado. NHLBI-NIDDK Working Group: The Pathophysiology of Obesity-Associated Cardiovascular Disease; State of the Science and Research Needs, May 2001, Washington, DC. Rockefeller University, Seminars in Clinical Research, May 2001 New York, NY. University of Minnesota, College of Biological Sciences, Department of Biochemistry, April, 2001, St. Paul, MN. Keystone Symposia on Molecular and Cellular Biology: PPARs: a Transcriptional Odyssey, February 2001, New Mexico. Johns Hopkins University School of Medicine, February 2001, Baltimore MD. The Scripps Research Institute, January 2001, La Jolla, CA. NAASO, Obesity in the New Millennium, October 2000, Long Beach, CA. Keystone Symposia on Molecular and Cellular Biology: Diabetes Mellitus and Molecular Control of Adipogenesis and Obesity, February 2000, New Mexico. Endocrine Grand Rounds, Vanderbilt University School of Medicine, Department of Medicine, May 1999, Nashville, TN. Endocrine Grand Rounds, Harvard Medical School and Beth Israel Deaconess Hospital, October 1998, Boston, MA. Columbia University, Naomi Berrie Diabetes Center, September 1998, New York, NY.

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Endocrine Grand Rounds, Harvard Medical School and Massachusetts General Hospital, December 1998, Boston, MA. 2nd International IBC Conference on Insulin Resistance, October 1997, Philadelphia, PA. NIH: The Brain and the Adipocyte: Integrating Diverse Signaling Pathways, September 1997, Bethesda, MD. Longwood Area Diabetes/Metabolism Research Seminar, November, 1997, Boston, MA. Aspen Lipid Conference: Lipoproteins, Insulin Resistance and Obesity, August 1997, Aspen, CO. Keystone Symposium on Molecular and Cellular Biology, January 1997, Park City, UT. Wise and Helen Burroughs Lecture, September 1996, Iowa State University, Ames, IA. MIT, Boston Obesity Nutrition Research Seminar Series, October 1996, Boston, MA. N.A. Association for the Study of Obesity, December 1995, Baton Rouge, LA. Endocrine Grand Rounds, Harvard Medical School and Beth Israel Deaconess Hospital, December 1995, Boston, MA. Boston Area Insulin Action Symposium, November 1995, Woods Hole, MA. Rockefeller University Hospital, Endocrinology/Metabolism Seminar, 1994, New York. Keystone Symposia: The Adipose Cell, January 1994, Salt Lake City, UT. North American Association for the Study of Obesity, October 1993, Milwaukee, WI. American Diabetes Association Annual Meetings, 1994, 1995, 1996, 1997, 1999, 2000, 2002, 2004, 2007.

International: • Wertheimer Award Lecture, 11th International Congress on Obesity, July 2010, Stockholm, Sweden • European Society for Padeiatric Gastroenterology, Hepatology and Nutrition, June 2010, Istanbul, Turkey. • Diabetes Conference, May 2010, Ankara, Turkey. • Closing Plenary, 11th Servier-IGIS Symposium entitled” The Stressed Beta-Cell”, March 2010, St. Jean Cap Ferrat, France • Keystone Symposia, February 2010, Banff, Canada. • Opening Keynote Lecturer, Diabetes Conference, May 2009, Ankara, Turkey. • 8th Congress of European Federation of Internal Medicine, May 2009, Istanbul, Turkey. • Servier Institute of Research, March 2009, Paris, France. • GlaxoKlineSmith Laboratory, April 2009, Paris, France. • Plenary Speaker, International Congress on Prediabetes and Metabolic Syndrome, April 2009, Nice, France. • Chair, 10th Anniversary Servier-IGIS Symposium: “A Decade of Islet Research: Implications for Understanding and Treating Type 2 Diabetes”, St. Jean-Cap-Ferrat, France. • Plenary Speaker, Diabetes Dialogue Conference, March 2009, Istanbul, Turkey. • Keystone Symposia, January 2009, Banff, Canada. • Keynote Lecturer, 25th International Gastroenterology Symposium, November 2008, Istanbul, Turkey. • Plenary Lecturer, 2nd Advances in Diabetes Symposium, October 2008, Barcelona, Spain. • Plenary Lecturer, ESPE, September 2008, Istanbul, Turkey. • John Denis McGarry Lecture, Montreal Diabetes Research Center, 2008, Montreal, Canada.

• Co-chair, 13th EASD/JDRF Oxford Workshop “Inflammation, Islets and Immunity, August 2008, Oxford, England. • European Research Council Meetings, June 2008, Brussels, Belgium. • Annual meeting of the Turkish Academy of Sciences, June 2008, Istanbul, Turkey. • Visiting scientist, Merck Frosst, January 2008, Montreal Canada. • Keynote Lecturer, GlaxoKlineSmith Symposium, January 2008, Montreal, Canada. • Keystone Symposia, February 2008, Alberta, Canada. • Keynote lecturer, Van d’Hebron Conference, December 2007, Barcelona, Spain. • Expo 2015 Planning Committee and Presentation, November 2007, Paris, France. • Keynote lecturer, 21st National Physical Medicine and Rehab Congress, October 2007, Antalya, Turkey. • Keynote lecturer, 2nd International Congress on Food and Nutrition, October 2007, Istanbul, Turkey. • Plenary lecturer, Nature/Merck Symposia on Inflammation, October 2007, Rome, Italy. • Keynote lecturer, 2nd International Congress on Prediabetes, April 2007, Barcelona, Spain. • Keynote speaker at ISH 2006 Sapporo Satellite Symposium on “Metabolic Syndrome, Adipocytokine, and Hypertension”, October 2006, Sapporo, Japan. • Novartis Foundation, “Fatty Acid & Lipotoxicity in Obesity and Diabetes”, October 2006, Beijing, China. • 134th Alfred Nobel Symposium, “The Adipocyte: a Multifunctional Cell” August 2006, Gotenburg, Sweden. • Keynote speaker at the 4th Scientific Meeting of Adipocytokine Research, July 2006, Tokyo, Japan. • Keynote speaker at the 3rd Annual Scientific Meeting of the Insulin Resistance and Metabolic Syndrome, July 2006, Tokyo, Japan. • 31st FEBS Congress: Molecules in Health & Disease, June 2006, Istanbul, Turkey. • 42nd National Diabetes Congress, May 2006, Istanbul, Turkey. • Principal Speaker, Korean Society for the Study of Obesity, Asian Metabolic Syndrome Consensus Meeting, April 2006, Seoul, Korea. • Plenary Lecture, Asian Pacific Society of Atherosclerosis and Vascular Diseases 5th Annual Meeting, April 2006, Jeju, Korea. • Keystone Symposium on Adipogenesis, Obesity, and Inflammation, January 2006, Vancouver, Canada. • Annual meeting of the Turkish Academy of Sciences, December 2005, Ankara, Turkey. • Keynote Lecturer, NAASO Annual Scientific Meeting, October 2005, Vancouver, Canada. • “Obesity, Metabolism, and Cancer,” October 2005, Ermatigen, Switzerland. • Keynote Lecturer, 10th Adiposcience Symposium, Osaka, Japan. • Chair, 4th International Stock Symposium: “Obesity and Inflammation”, March 2005, Istanbul, Turkey. • 6th Servier-IGIS Symposium: “Type 1 and Type 2 Diabetes: Less Apart than Apparent?" March 2005, St. Jean-Cap-Ferrat, France. • Altana Research Conference, July 2005, Lake Constance, Germany. • 3rd International Congress of Obesity, May 2004, Antalya, Turkey. • 2004 Keystone Symposium on Diabetes Mellitus: Molecular Signaling, Genes and Therapeutics, March 2004, Banff, Canada.

• “Searching for Tomorrow-Yarini Arayis” High-Level Strategy/Brainstorming Meeting, February 2004, Antalya, Turkey. • 7th Scientific Session of the Japanese Society of Cardiovascular Endocrinology and Metabolism, November 2003, Sapporo-city, Japan. • Between Obesity and Diabetes Symposium, October 2003, Barcelona, Spain • Invited lecture at Seoul National University, October 2003, Seoul, Korea. • Symposium Lecturer, Korean Society for Molecular Cell Biology, October 2003, Seoul, Korea. • 39th National Diabetes Congress, May 2003, Istanbul, Turkey. • Keynote Lecturer Japanese Circulation Society Meeting, March 2003, Fukuoka, Japan. • Sapporo Medical University, Internal Medicine March 2003, Sapporo, Japan. • D.B. Brown Research Chair on Obesity, November 2002, Quebec, Canada. • Satellite Symposium on Obesity, August 2002, Rio de Janeiro, Brazil. • 9th International Congress on Obesity. August 2002, Sao Paulo, Brazil. • 38th National Diabetes Congress, May 2002, Antalya, Turkey. • 18th Ernst Klenk Conference, February 2002, Cologne, Germany. • International Focus on Diabetes Conference, December 2001, Sicily, Italy. • Invited lecturer at Bilkent University, June 2001, Ankara, Turkey. • Astra-Zeneca International Workshop on Obesity, February 2001, Nice France. • Japanese Diabetes Society Millennium Meeting, May 2000, Nagoya, Japan. • International Symposium on Nutrition and Dietetics, April 2000, Ankara, Turkey. • Recent Advances in Adipocyte Biology, November 1999, Quebec City, Canada. • Distinguished Lecturer, Oslo University’s Biotechnology Center, October 1999, Oslo, Norway. • 22nd Congress of Endocrine Society, October 1999, Antalya, Turkey • European Congress of Pharmacology, July 1999, Budapest, Hungary. • IFCC Congress of Clinical and Molecular Biology, June 1999, Florence, Italy. • International Symposium on Lipoprotein Metabolism, December 1998, Kyoto, Japan. • 5th IUBMB: Biochemistry of Health and Disease, October 1998, Jerusalem, Israel. • 8th International Congress on Obesity, August 1998, Paris, France. • Pew Scholars Program in the Biomedical Sciences, March 1998, 1999, 2000, and 2001, in Puerto Vallarta, Mexico, Curaçao, Netherlands Antilles, Cozumel, Mexico, and Costa Rica, South America, respectively. • Japanese Diabetes Society, Molecular Diabetology, December 1997, Nagoya, Japan. • Annual Meeting of Adipo-Science, August 1997, Osaka, Japan. • Karolinska Symposium on Genes and Obesity, Karolinska Institute, Huddinge Hospital. August 1997, Stockholm, Sweden. • 16th International Diabetes Federation Congress, July 1997, Helsinki, Finland. • Human Genome Project: Perspectives in Molecular Medicine, July 1997, Ankara, Turkey. • 22nd International Symposium on Growth Factors in Endocrinology and Metabolism. October 1996, Vienna, Austria. • 4th International Non-Insulin dependent Diabetes, December 1996, Amsterdam, Netherlands. • Centre National de la Recherce Scientifique, Biochemistry Seminar at University of Nice-Sophia Antipolis, November 1995, Nice, France. • Obesity: Recent Advances and Prospects for Therapy, December 1995, London, UK.

• Cellular and Molecular Biology of Adipocyte Development and Growth. August 1994, Ottawa, Canada. • 7th International Congress on Obesity. August 1994, Toronto, Canada

RESEARCH SUPPORT: Completed: 1996-1998 1996-1998 1996-2003 1997-2000 1997-2002 1998-2002 2001-2002 2002-2003 2003-2003 2003-2005 2003-2006 1998-2002 2000-2004 2004-2008 2005-2009 Joslin Diabetes Center DERC, P&F Grant Harvard Clinical Nutrition Research Center, P&F Grant Bristol-Myers Squibb Pharmaceutical Research Institute American Diabetes Association Career Development Award Pew Scholar in Biomedical Sciences Award National Institute of Health (RO1) Bristol-Myers Squibb Pharmaceutical Research Institute National Institute of Health (R21) Biovitrum Pharmaceutical Corp. Research Institute American Diabetes Association Sandler Program for Asthma Research NIH/NIDDK NIH/NIDDK NIH/NHLBI National Institute of Health (RO1) PI PI PI PI PI PI PI Co-PI PI PI PI PI PI Co-PI Co-PI Role of TNF receptors in insulin resistance Leptin signaling and insulin sensitivity Metabolic role of adipocyte fatty acidbinding protein Biological role of membrane-bound TNF! Fatty acid trafficking, regulation of gene expression and metabolic control: the biology of FABPs Leptin, cytokines and insulin resistance Molecular basis of altered adipocyte biology in HIV-related lipodystrophy. Fatty acid binding proteins in macrophage function FABP inhibitors in diabetes Role of fatty acid-binding proteins in type 2 diabetes Novel pathways controlling inflammatory responses in asthma Leptin, cytokines and insulin resistance Molecular basis of adipogenesis Dietary etiologies of heart disease and cancer The role of fatty acid-binding proteins in atherosclerosis

Current: 1996-2015 20032009-2014 2010-2015 2008-2011 2008-2012 2009-2011 National Institute of Health (RO1) James Stevens Simmons Endowment National Institute of Health (RO1) Syndexa Pharmaceuticals Juvenile Diabetes Research Foundation American Diabetes Association Post-doctoral Mentored Fellowship Technology Development Accelerator Fund of Harvard University PI PI PI PI PI PI PI Lipids, inflammation, and insulin action Targeting cellular stress pathways for the treatment of metabolic syndrome Endoplasmic reticulum stress, inflammation and type 1 diabetes Inflammatory mechanisms underlying insulin resistance and associated pathologies Development of therapeutic antibody against diabetes and related metabolic diseases TNF receptor function in insulin resistance and obesity

TRAINING GRANTS: Active: Co-Principal Investigator NIH/NIEHS- T32 ES016645 Interdisciplinary Training in Genes and the Environment The two interrelated goals of our proposed training program are 1) To train true collaborative partners able to pursue methodological research that is motivated by, and helps to solve, difficult analytic issues that arise in studies of human environmental exposures and genetic susceptibility to complex diseases; and 2) To encourage interdisciplinary research, especially in genetics and the various “omics” arising from new methodologies for characterizing biological activity associated with environmental exposures in laboratory and population sciences. Co-Principal Investigator NIH/NCI- T32 CA009078 Radiation Biology Training Program The overall goal of this program is to train predoctoral and postdoctoral researchers to engage address the problem of understanding the effects of radiation and related agents at the cellular and molecular level. Past: Co-Principal Investigator: NIH-T90DK070078 R90DK071507 Roadmap Training Grant in Genetics and Complex Diseases The goal of this program is to support graduate and postgraduate educational opportunities and training in interdisciplinary context within the Genetics and Complex Diseases.

Principal Investigator: NIH-T32 ES007155 Training Program in Environmental Health The overall goal of this program is to strive to train environmental health scientists with an emphasis on excellence in the application of molecular and cellular tools to environmental problems. This program continues to recruit and maintain an outstanding group of graduate students and postdoctoral trainees. At the current time, we support 12 graduate students in four departments within the biological sciences at the Harvard School of Public Health. Principle Investigator: NIH-T35ES007300 Undergraduate Minority Summer Internship Program The goals of this program are to support research training in a number of diverse health-related areas for undergraduate minority students and prepare and promote the careers of undergraduate minority scientists. The program supports minority students in our summer long laboratory based program. PATENTS 10 patents at different levels of prosecution, 2 issued FELLOWS:
Past Trainees Trainee Name Atsumi, G Training Period 2001-2002 Institution, Degree U. of Tokyo, 1998, PhD Title of Research Project Role of lipid chaperons stress and adipocyte function Lipid chaperones and lipokines ER stress in obesity and insulin action Macrophage stress responses and survival Chaperons and metabolism Current Position Associate Professor Teikyo U. Pharm.Dep. National Institutes of Health, Bethesda, MD Group Leader Amgen Assistant Professor Bilkent U. Dep. of MBG Assistant Professor Sapporo Med. U.

Cao, H Cao, Q Erbay, E

20032002-2006 2004-

U. of Nevada, 2003, PhD NYU Med. Sch., 2002, PhD Ankara U. Sch. of Med., 1998 MD; U. of Illinois, 2004, PhD Sapporo Med. Sch. 2002, MD, PhD Gazi Med. Sch., 1993, MD U. of Tokyo, 1993, PhD

Furuhashi, M Gorgun, C Hirosumi, J

2004-2009 1999-2009 2000-2001

Mouse genetics and Research Liaison physiological studies Amgen Inflammation, JNK and insulin action Scientific Director Fujisawa Pharm.

Hom, X Kono, K Maeda, K Makowski, L

1999-2002 2004-2006 1999-2002 1998-2004

New York U., 1993. MD Kyoto U., 2002, PhD Osaka U., 1997, PhD Harvard U., School of Public Health, 2003, PhD Pontifical Catholic U., 2002, PhD U. of Ghana, 2000, BS U. of Istanbul, 2004, MD U. of Istanbul 2005, MD Tubingen U., 1996, PhD Oxford U., 1997, PhD Auburn U.,1999, MS

Inflammation in liver pathology Functions of lipid binding proteins Mechanisms of FABP function Mechanisms of inflammation in macrophages Inflammation in the adipose tissue JNK and insulin action in vitro ER stress in obesity and insulin action ER Stress in obesity and insulin action Cellular responses to lipid signals TNF and Insulin Action Mechanisms of adipocyte differentiation STAMP and macrophage function Adipocyte commitment and differentiation factors Role of GATA factors in brown adipogenesis TNF-!, inflammation and insulin action

Assistant Professor UC San Diego Senior Scientist Sankyo Co., Inc, Associate Professor Osaka U. Assistant Professor UNC Chapel Hill Assistant Professor U. of Chile Postdoctoral Fellow Postdoctoral Fellow Columbia U. Assistant Professor Children’s Hospital Senior Scientist Eli Lilly Lecturer Cambridge U. Research Scientist Millennium Pharm. U. of Cologne

Morgan, C Otoo, N Ozcan, L Ozcan, U Scheja, L Sethi, J Tan, G

2005-2007 2002-2003 2004-2007 2002-2006 1996-2001 1996-2000 2000-2002

ten Freyhaus, H Tong, Q

2008-

U. of Cologne, 2004, MD

1997-2002

Ohio State U., 1997, PhD

Baylor College, Assistant Professor

Tsai, J

1999-2004

Harvard U. School of Public Health, 2004, PhD Carnegie Mellon, 2003, MBA

Research Scientist

Uysal, T

1995-2001

CEO and President Syndexa Pharm.

Vallerie, S Wellen, K Xu, H Yilmaz, E

20032000-2006 1996-2000 2002-2005

Emory University 2000, BS Harvard U. School of Public Health, 2006, PhD Harvard U. School of Public Health, 1996, PhD Ankara U. Med. Sch., 1999, MS

JNK and insulin action Inflammatory and metabolic responses Inflammation, TNF and adipose tissue Stress pathways, JNK and insulin action

U. of Wash., Seattle Postdoctoral Fellow U. Penn. Assistant Professor Brown U. Med. Sch., Assistant Professor Ankara U.

Current trainees Trainee Name Arruda, AP Calay, E Training Period 2009 2008Institution, Degree Federal U. of Rio de Janeiro, 2008, PhD Sabanci U., 2007, BS Title of Research Project Mitochondrial function Metabolic response to nutrient and chronic inflammation Investigating the role of lipids in aging ER stress in diabetes Role of FABP4 in adipocyte function Systems approaches for ER stress & inflammation ER stress in adipocyte biology and inflammation Transcriptional Regulation of ER stress by ATF6! Chemical biological approaches to modulate metabolism Current Source of Support PEW Scholarship NIH-T32- Cancer Training grant Graduate Prize Fellowship Juvenile Diabetes Research Foundation NIH – T-32 Training grant Hotamisligil Research Funds Pritzker Fellowship

Charles, K Engin, F Erikci, M

200720082009

San Diego State U., 2007, MS Baylor College of Med., 2007, PhD Bilkent U., 2008, BS

Fu, S

2007-

U. of Georgia, 2004, PhD

Gregor, M

2005-

Harvard U., 2010, PhD

Hummasti, S

2008-

UCLA, 2006, PhD

NIH-T32 Training grant Hotamisligil Research Funds

Li, P

2007

Peking U., 2003, PhD

Nakamura, T

2006-

U. of Tokyo, 2003, PhD

Pathogen sensing and nutrient response Lipid chaperones and metabolism Inflammation and metabolism Role of inflammatory stress pathways and lipid chaperons Genomic approaches to decode organelle dysfunction Autophagy, stress and metabolism

Human Frontiers Postdoctoral Fellowship Japanese Foundation Fellowship Endocrine Fellowship Juvenile Diabetes Research Foundation Hotamisligil Research Funds AHA Postdoctoral Fellowship

Seikya, M Tirosh, A Tuncman, G

2009 2009 2000-

U. of Tokyo, 2005, MD, PhD Ben-Gurion U. 2001, MD, Ph.D. Ankara U. Sch. of Med., 1999, PhD Georg August U., 2007, PhD Kent State U., 2007, PhD

Yalcin, A

2007-

Yang, L

2007-