home work assignment
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QL1 Individual Assessment Answer Sheet
Individual Assessment #3
Name: Banner ID: QL Section: Date: Question 1 John Theiss 1220536 27 9/23/2011 Predict in a quantitative way (i.e. "with numbers"), the rate of glucose excretion by the kidney at different plasma glucose concentrations. Use the "Graph Answers" sheet for your answers. See the Question 1 description in the IA3 handout for further details. Note that Questions 2-4 are based on this glucose excretion curve, so be extra careful answering this question!
Use the "Graph Answers" sheet for Question 1. Question 2 Compare and contrast the glucose excretion curve (i.e. blue line on your graph) with the glucose filtration curve (i.e. the red dots). "Compare" means in what ways are the two curves similar; "contrast" means in what ways are the two curves different. They are exactly the same until the glucose filtration and excretion rate reaches 468.75, where it remains at this level even as the plasma glucose increases.
Question 3
What is the relationship between the SGLT transport maximum, the renal threshold and the glucose excretion curve?
QL1 Individual Assessment Answer Sheet
The relationship between the SGLT transport masimum, the renal threshold and the gludose excreation curve is that they all share a positive relationship.
Question 4
In normal individuals - people who do not have diabetes mellitus - plasma glucose concentrations normally range between 100 and 200 mg/100 ml. Based only on your plot of glucose excretion rate on the Graph Answers sheet, explain why normal people do not have any measureable amount of glucose in their urine? They don’t have measurable amounts of glucose, for they aren't near the excretion level necessary to show measurable amounts.
Question 5
Suppose you decide to donate one of your kidneys to a close relative. Given that the normal range of plasma glucose is 100 to 200 mg/100 mL, would you now expect to measure some glucose in your urine? Why or why not? (Remember you must justify your answer with two or more complete, wellwritten sentences to receive credit).
QL1 Individual Assessment Answer Sheet
I would not because my glucose level would only be lowered, because of the reduction of the kidney, showing less measurable glucose in the urine.
QL1 Individual Assessment Answer Sheet
Homework #3
Question 1: Replace the 100's in the Excretion Rate column below with your predicted values.
Plasma Glucose
Excretion Rate
Glucose Filtration and Excretion Rate (mg/min)
5 53 105 149 197 245 313 345 393 449 521 581 605
6.25 66.25 131.25 186.25 246.25 306.25 391.25 431.25 468.75 468.75 468.75 468.75 468.75
Filtration Rate (mg/min) Excretion Rate (mg/min) Linear (Filtration Rate (mg/min)) 800 700 600 500 400 300 200 100 0 0 200 400 600 800 Plasma Glucose (mg/ 100 mL)
y = 1.25x
Filtr. Rate (mg/min) 7 Plasma Gluc. (mg/100 mL) 55
604 448 148
560 185 305
244 312 520 344 196 580 52 392 4 104
390 650 430 245 725 65 490 5 130
Individual Assessment #3
Name: Banner ID: QL Section: Date: Question 1 John Theiss 1220536 27 9/23/2011 Predict in a quantitative way (i.e. "with numbers"), the rate of glucose excretion by the kidney at different plasma glucose concentrations. Use the "Graph Answers" sheet for your answers. See the Question 1 description in the IA3 handout for further details. Note that Questions 2-4 are based on this glucose excretion curve, so be extra careful answering this question!
Use the "Graph Answers" sheet for Question 1. Question 2 Compare and contrast the glucose excretion curve (i.e. blue line on your graph) with the glucose filtration curve (i.e. the red dots). "Compare" means in what ways are the two curves similar; "contrast" means in what ways are the two curves different. They are exactly the same until the glucose filtration and excretion rate reaches 468.75, where it remains at this level even as the plasma glucose increases.
Question 3
What is the relationship between the SGLT transport maximum, the renal threshold and the glucose excretion curve?
QL1 Individual Assessment Answer Sheet
The relationship between the SGLT transport masimum, the renal threshold and the gludose excreation curve is that they all share a positive relationship.
Question 4
In normal individuals - people who do not have diabetes mellitus - plasma glucose concentrations normally range between 100 and 200 mg/100 ml. Based only on your plot of glucose excretion rate on the Graph Answers sheet, explain why normal people do not have any measureable amount of glucose in their urine? They don’t have measurable amounts of glucose, for they aren't near the excretion level necessary to show measurable amounts.
Question 5
Suppose you decide to donate one of your kidneys to a close relative. Given that the normal range of plasma glucose is 100 to 200 mg/100 mL, would you now expect to measure some glucose in your urine? Why or why not? (Remember you must justify your answer with two or more complete, wellwritten sentences to receive credit).
QL1 Individual Assessment Answer Sheet
I would not because my glucose level would only be lowered, because of the reduction of the kidney, showing less measurable glucose in the urine.
QL1 Individual Assessment Answer Sheet
Homework #3
Question 1: Replace the 100's in the Excretion Rate column below with your predicted values.
Plasma Glucose
Excretion Rate
Glucose Filtration and Excretion Rate (mg/min)
5 53 105 149 197 245 313 345 393 449 521 581 605
6.25 66.25 131.25 186.25 246.25 306.25 391.25 431.25 468.75 468.75 468.75 468.75 468.75
Filtration Rate (mg/min) Excretion Rate (mg/min) Linear (Filtration Rate (mg/min)) 800 700 600 500 400 300 200 100 0 0 200 400 600 800 Plasma Glucose (mg/ 100 mL)
y = 1.25x
Filtr. Rate (mg/min) 7 Plasma Gluc. (mg/100 mL) 55
604 448 148
560 185 305
244 312 520 344 196 580 52 392 4 104
390 650 430 245 725 65 490 5 130
