Nail Patella

Published on September 2017 | Categories: Documents | Downloads: 85 | Comments: 0 | Views: 462
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Nail Patella Syndrome and ABO blood group The condition involving strange fingernails and kneecaps is called nail patella syndrome (NPS). (The patella is the kneecap.) The gene that causes this is found on chromosome 9. It codes for a protein that is involved in the development of limbs in the embryo. Most people with this syndrome do not need any medical treatment, but they are at a greater risk of developing kidney disease than other people. The allele that causes nail patella syndrome is dominant. The gene locus that determines ABO blood group is also on chromosome 9, and it is very close to the nail patella syndrome gene. During meiosis, when the homologous chromosomes separate, the blood group and nail patella alleles stay together Whatever the combination in which they were present in the parent cell, they stay in the same combination in the gametes that are formed. So, when gametes are formed, the alleles do not assort independently. They stick together and stay in the same combinations as in the parent cell. For example, blood may be inherited same chromosome, known as autosomal

group B and nail patella syndrome together. If the two genes are on the they are said to be linked. This is linkage.

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