PRAVI..Ppi vs h2

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WELCOME

PR OTON OTON PUM PUMP INHIBITORS INHIBITORS VS H2 R ECEP ECEPTOR  TOR ANTAGONI ANTAGONIS STS

SYM SYMPTOMS TOMS OF GAS GASTR OINTES OINTESTINAL DYSF YSFUNCTION

symptoms can arise from GI dysfunction. Common GI symptoms include heartburn, abdominal abdominal pain, dyspepsia, nausea , vomiting, diarrhoea , constipation, and gastrointestinal  bleeding. Signs and symptoms of malabsorption, hepatitis, and GI infection i nfection are also commonly commonly seen.

PEPTIC ULCER  DISEASE

 peptic

ulcer is an abnormal area of mucosa which has been damaged by the pepsin and hydrochloric acid of gastric juice.

 consequent

inflammation of the underlying and surrounding tissues.

 most

ulcers occurs in duodenum or in the stomach ,where ph is sufficiently low.

AETIOLOGY  H.PYLORI  NSAID

INFECTION

INGESTION

 STRESS

INDUCED

 HEREDITY  COMMON

ON O BLOOD GROUPS

 SMOKING  ALCOHOL  AGE

MORE THAN 60 YEARS

 CORTICOSTEROIDS

GASTROESOPHAGEAL REFLUX DISEASE Gastroesophageal reflux disease (GERD) is a common medical disorder for symptoms, such as heartburn , dysphagia or bleeding. Endoscopy is used to evaluate mucosal damage from gastroesophageal reflux disease (GERD) key factor in the development of GERD is the retrograde movement of acid or other noxious substances from the stomach into the oesophagus.

ZOLLINGER-ELLISON SYNDROME

ZES

is characterized by gastric acid hyper  secretion and recurrent peptic ulceration that results from a gastrin-producing tumour  (gastrinoma). 90% of gastrinomas are located in the region of the pancreas, the most common site being the duodenum. Malignant gastrinomas occur in 30% to 50% of patients, with metastases to regional lymph nodes, liver, spleen, and bone.

COUNSELLING  Drug to be taken before meals  Don¶t crush the capsules BRAND NAMES FORM STRENGTH 1)OMEZ CAP 10,20mg 2)OCID CAP 10,20mg 3)OMEZ INJ 4)OMEZ TAB

40mg 40mg

LANSOPRAZOLE CLASSIFICATION PHARMACOLOGIC :acid pump inhibitor  THERAPEUTIC

:antiulcerative

MECHANISM OF ACTION  INHIBITS THE ACTIVITY OF

PROTON PUMP,H+/K+ AT PASE ± SECRETORY SURFACE OF GASTRIC PARIETAL CELL.

 BLOCKS

FORMATION OF GASTRIC ACID

INDICATIONS.R OUTE AND DOSAGE

 ACTIVE

DUODENAL ULCER  15mg P.O once daily for 4 weeks  TREATMENT FOR EROSIVE ESOPHAGITIS 30 mg P.O once daily up to 8 weeks  ZOLLINGER ELLISON SYNDROME Initially 60 mg once daily increased up to 180 mg/day  TREATMENT FO GASTRIC ULCER  30 mg P.O daily up to 8 weeks

 GERD

15 mg P.O daily up to 8 weeks  H.PYLORI ERADICATION DUAL THERAPY LANSOPRAZOLE : 30mg AMOXICILLIN :1000mg Given t.i.d for 14 days TRIPLE THERAPY LANSOPRAZOLE : 30mg AMOXICILLIN :1000mg CLARITHROMYCIN : 500mg

 GERD

150mg P.O b.i.d  EROSIVE

ESOPHAGITIS

150 mg or 10ml P.O q.i.d  FOR OCCASSIONAL HEARTBURN , ACID

INDIGESTION , AND SOUR STOMACH 75 mg once or twice daily or 150 mg o.d INTERACTIONS  Decreased ranitidine  Increased

absorption with antacids

hypoglycemic effects with glipizide

ADVERSE REACTIONS Granulocytopenia , pancytopenia , thrombocytopenia COUNSELLING  if patient taking single dose take it

at bed time

 Not

to take otc for a period of 2 weeks without mediacal approval

BRANDS

FORM

1)RANTAC

TAB,INJ

2)RANITIN

STRENGTH 150,300mg

Thank you 

30

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