Drugs Used in Pregnancy

Published on December 2016 | Categories: Documents | Downloads: 51 | Comments: 0 | Views: 377
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Teratogenic potency of drugs and
other disadvantages
Drug dosage and the ability to cross
the placenta
The stadium of pregnancy
General condition of the mother.

Elimination :
Renal blood flow and GFR increase
“Steady state” only slight declines but the dosage
does not need increase

Drug could damage the fetus :
1. Directly
2. Indirectly


Placental
determinants
Area
exchange
Thickness of
membranes
Enzyme
systems
Drug
determinants
Molecular
weight < 600
Lipid soluble
Non-charged,
basic
Death =>
abortion
Malformation /
anomalies
Changing in
behavior
Retardation

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