Enbrel Side Effects
Content
Enbrel Side Effects: An Introduction
As with any medicine, side effects can occur with Enbrel® (etanercept). However, not everyone who takes this medicine will have problems. In fact, most people tolerate it well. If people do develop side effects, in many cases, they are minor, meaning they re uire no treatment or are easily treated by you or your healthcare provider. (This article covers many, but not all, of the possible side effects with Enbrel. Your healthcare provider can discuss a more complete list of Enbrel side effects with you.)
Common Side Effects of Enbrel
!nbrel has been studied thoroughly in clinical trials, with many people having been evaluated. In these studies, the side effects occurring in a group of people taking the drug were documented and compared to the side effects that occurred in a similar group of people not taking the medicine. As a result, it is possible to see what side effects occur, how often they appear, and how they compare to the group not taking the medicine. "ased on these studies, the most common side effects of Enbrel include#
• In$ection site reactions (redness, rash, swelling, itching, or bruising) %% in up to &'
percent of people
• • • • • • • • • • • •
Infections such as the common cold or a sinus infection %% up to &( percent Headaches %% up to )' percent Irritated or runny nose %% up to )* percent +i,,iness %% up to ' percent Sore throat %% up to ' percent -ough %% up to . percent /eneral weakness %% up to ( percent Abdominal pain (stomach pain) %% up to ( percent "reathing problems %% up to ( percent Heartburn %% up to 0 percent 1omiting %% up to & percent 2outh ulcers (canker sores) %% up to * percent.
Side Effects to Report
3ome Enbrel side effects, while occurring infre uently, are potentially serious and should be reported immediately to your healthcare provider. 4hese include but are not limited to#
• 3ymptoms of an infection, including cough, chills, fever, or weakness • • • • •
5umb or tingling feeling -hanges in vision 6eakness in your arms and7or legs, along with di,,iness -hest pain (see Enbrel and Heart Attacks) 3igns of an allergic reaction, including#
o An une8plained rash o Hives o Itching o 6hee,ing or difficulty breathing o 9ne8plained swelling
• :ever, sore throat, chills, and other signs of infection • • • • • • •
9nusual bruising or bleeding +ifficult or painful urination "lood in the urine 9nusual bleeding, bruising, or pale skin 3wollen lymph nodes 3welling of the legs or arms Depression (see Enbrel and Depression).
Rare Side Effects Seen With Enbrel
;are side effects occur in less than ) percent of people taking !nbrel. "ecause these side effects are so uncommon, it is difficult to tell whether they are because of !nbrel or something else. 3ome of these possible side effects include but are not limited to#
• 3erious infections, including#
o Cellulitis o <steomyelitis o Pneumonia o Pyelonephritis (kidney infection)
• Congestive heart failure • • • • • •
"lood clot deep in a leg vein (known medically as deep vein thrombosis or DVT) "lood clot in the lungs (pulmonary embolism) Pancreatitis Appendicitis Kidney stones =ymphoma (cancer of the lymphatic system).
Final Thoughts
>ou may e8perience some or none of the side effects listed in this article. 9nfortunately, there is no way for your healthcare provider to know beforehand if you will have side effects from a medicine that you have never tried. 4herefore, be sure to let your healthcare provider know if you develop any side effects while taking this medication. Also, let your healthcare provider know if you develop something that ?$ust does not seem right.? 6hile it may not be an Enbrel side effect, your healthcare provider will be able to diagnose and treat the problem.
http://arthritis.emedtv.com/enbrel/enbrel-side-effects.html
Enbrel Side Effects High re!uency of "ccurrence
•
Development of autoantibodies # in particular, users developed antinuclear antibodies (ANA), anti-double-stranded NA antibodies and anticardiolipin antibodies. The development of antibodies may indicate that one could develop an autoimmune disease. $mmune system reactions $nfections # includin! upper respiratory infections, pyelonephritis (i.e. "idney infection#inflammation), bronchitis, septic arthritis, abdominal abscess, cellulitis (i.e. s"in infection), osteomyelitis (i.e. bone infection), wound infection, pneumonia, foot abscess, le! ulcer, diarrhea, sinusitis, and sepsis (i.e. an infection in the blood), !astroenteritis (i.e. infection of the stomach and intestines), tuberculosis $n%ection site reactions # includes mild to moderate erythema (i.e. redness) and#or itchin!, pain or swellin!$ bleedin! and bruisin! at the in%ection site &alignancies 'Cancers( # includin! lymphomas such as non-&od!"in's lymphoma, colon cancer, breast cancer, lun! cancer, prostate cancer, non-cutaneous solid tumors, basal cell s"in cancer and s(uamous cell s"in cancer
• •
• •
Enbrel Side Effects &edium re!uency of "ccurrence
• • • • • • • • • • • • • • • •
Abdominal pain Alopecia Asthenia % !eneral wea"ness#loss of stren!th -ough +i,,iness +yspepsia Headache 2outh ulcer 5ausea @eripheral edema % swellin! in the arms and le!s @haryngitis % sore throat ;ash ;espiratory disorder ;hinitis % runny nose 3inusitis % sinus infection#inflammation 1omiting
Enbrel Side Effects )o* re!uency of "ccurrence
• • • • • • • • • • • • •
Appendicitis "ursitis % inflammation of the bursae -erebral ischemia % insufficient blood flow to the brain -holecystitis % inflammation of the !allbladder +eep vein thrombosis +epression +yspnea % difficulty breathin! /astrointestinal bleeding Heart failure Hypertension % hi!h blood pressure Hypotension % low blood pressure Aidney calculus % "idney stones =ymphadenopathy % enlar!ed lymph nodes ()swollen !lands))
• • • • • • • • • • • • •
2embranous glomerulonephropathy % a type of "idney disorder 2ultiple sclerosis 2yocardial infarction 2yocardial ischemia 5ormal pressure hydrocephalus % an increase in pressure in the brain caused by e*cessive fluid in the brain @ancreatitis % inflammation of the pancreas @olymyositis % wea"ness and inflammation of the muscles @ulmonary embolism % blood clot in the lun!s 3arcoidosis 3ei,ure 3troke 4hrombophlebitis % a blood clot in a vein 6orsening psoriasis
Adverse in Children *ith +uvenile $diopathic Arthritis '+$A(
re!uently "ccur,
• • • •
Abdominal pain Headache 5ausea 1omiting
Sometimes "ccur,
• • • • • • • •
-utaneous ulcer % s"in ulcer +epression7personality disorder !sophagitis7gastritis /astroenteritis /roup A streptococcal septic shock 3oft tissue and post%operative wound infection 4ype ) diabetes mellitus 1aricella % chic"en po*
Post#&ar-eting Enbrel Side Effects
4he following !nbrel side effects were reported A:4!; !nbrel was approved and being used by the general population. >ou should note though that they were reported voluntarily by folks in the general population so there is therefore no way to determine how often they occur or if there is even really a true connection between them and !nbrel. Adults
• • • • • • • •
Adenopathy % enlar!ed#swollen lymph nodes Altered sense of taste Anemia Angioedema Anore8ia % loss of appetite Aplastic anemia % failure of the bone marrow to produce blood cells Autoimmune hepatitis -entral nervous system events suggestive of multiple sclerosis or isolated demyelinating conditions such as transverse myelitis inflammation of the nerves of the
• • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • •
spinal cord or optic neuritisinflammation of the optic nerve i.e. the nerve that (simply put) connects the eye to the brain -hest pain -utaneous vasculitis % inflammation of the blood vessels in the s"in +iarrhea +ry eyes +ry mouth +yspnea % difficulty breathin! !rythema multiforme % red, blistery rash :atigue :ever :lu syndrome /enerali,ed pain Interstitial lung disease % inflammation#swellin! of the lun!s that can cause scarrin! Intestinal perforation Boint pain =eukopenia % a type of low white blood cell count =upus%like syndrome with manifestations including rash consistent with subacute or discoid lupus 5eutropenia a type of low white blood cell count 5ew%onset congestive heart failure <cular inflammation % eye inflammation @ancytopenia abnormally low levels of all types of blood cells @aresthesias % numbness or tin!lin! of the s"in @ruritus % itchin! @ulmonary disease % lun! disease 3ei,ures 3tevens%Bohnson syndrome 3troke 3ubcutaneous nodules % lump#lesion#mass under the s"in 4hrombocytopenia % low blood platelet count 4o8ic epidermal necrolysis % blisterin!#peelin! of the top layer of the s"in (can be lifethreatenin!) 9rticaria % hives$ itchy rash 1asodilation (flushing) 6eight gain 6orsening of prior lung disorder
Children
• • • • • • • • •
Abscess with bacteremia % abscess with a bacterial infection of the blood -oagulopathy % a condition that affects the normal clottin! of the blood -utaneous vasculitis % inflammation of the blood vessels in the s"in <ptic neuritis % inflammation of the optic nerve i.e. the nerve that (simply put) connects the eye to the brain @ancytopenia % abnormally low levels of all types of blood cells 3ei,ures 4ransaminase elevations % there are en+ymes produced by the liver 4uberculous arthritis % infection of the %oints due to tuberculosis 9rinary tract infection
http://www.drug-side-effects-and-clinical-trials.com/enbrel_side_effects.html
As with any medicine, side effects can occur with Enbrel® (etanercept). However, not everyone who takes this medicine will have problems. In fact, most people tolerate it well. If people do develop side effects, in many cases, they are minor, meaning they re uire no treatment or are easily treated by you or your healthcare provider. (This article covers many, but not all, of the possible side effects with Enbrel. Your healthcare provider can discuss a more complete list of Enbrel side effects with you.)
Common Side Effects of Enbrel
!nbrel has been studied thoroughly in clinical trials, with many people having been evaluated. In these studies, the side effects occurring in a group of people taking the drug were documented and compared to the side effects that occurred in a similar group of people not taking the medicine. As a result, it is possible to see what side effects occur, how often they appear, and how they compare to the group not taking the medicine. "ased on these studies, the most common side effects of Enbrel include#
• In$ection site reactions (redness, rash, swelling, itching, or bruising) %% in up to &'
percent of people
• • • • • • • • • • • •
Infections such as the common cold or a sinus infection %% up to &( percent Headaches %% up to )' percent Irritated or runny nose %% up to )* percent +i,,iness %% up to ' percent Sore throat %% up to ' percent -ough %% up to . percent /eneral weakness %% up to ( percent Abdominal pain (stomach pain) %% up to ( percent "reathing problems %% up to ( percent Heartburn %% up to 0 percent 1omiting %% up to & percent 2outh ulcers (canker sores) %% up to * percent.
Side Effects to Report
3ome Enbrel side effects, while occurring infre uently, are potentially serious and should be reported immediately to your healthcare provider. 4hese include but are not limited to#
• 3ymptoms of an infection, including cough, chills, fever, or weakness • • • • •
5umb or tingling feeling -hanges in vision 6eakness in your arms and7or legs, along with di,,iness -hest pain (see Enbrel and Heart Attacks) 3igns of an allergic reaction, including#
o An une8plained rash o Hives o Itching o 6hee,ing or difficulty breathing o 9ne8plained swelling
• :ever, sore throat, chills, and other signs of infection • • • • • • •
9nusual bruising or bleeding +ifficult or painful urination "lood in the urine 9nusual bleeding, bruising, or pale skin 3wollen lymph nodes 3welling of the legs or arms Depression (see Enbrel and Depression).
Rare Side Effects Seen With Enbrel
;are side effects occur in less than ) percent of people taking !nbrel. "ecause these side effects are so uncommon, it is difficult to tell whether they are because of !nbrel or something else. 3ome of these possible side effects include but are not limited to#
• 3erious infections, including#
o Cellulitis o <steomyelitis o Pneumonia o Pyelonephritis (kidney infection)
• Congestive heart failure • • • • • •
"lood clot deep in a leg vein (known medically as deep vein thrombosis or DVT) "lood clot in the lungs (pulmonary embolism) Pancreatitis Appendicitis Kidney stones =ymphoma (cancer of the lymphatic system).
Final Thoughts
>ou may e8perience some or none of the side effects listed in this article. 9nfortunately, there is no way for your healthcare provider to know beforehand if you will have side effects from a medicine that you have never tried. 4herefore, be sure to let your healthcare provider know if you develop any side effects while taking this medication. Also, let your healthcare provider know if you develop something that ?$ust does not seem right.? 6hile it may not be an Enbrel side effect, your healthcare provider will be able to diagnose and treat the problem.
http://arthritis.emedtv.com/enbrel/enbrel-side-effects.html
Enbrel Side Effects High re!uency of "ccurrence
•
Development of autoantibodies # in particular, users developed antinuclear antibodies (ANA), anti-double-stranded NA antibodies and anticardiolipin antibodies. The development of antibodies may indicate that one could develop an autoimmune disease. $mmune system reactions $nfections # includin! upper respiratory infections, pyelonephritis (i.e. "idney infection#inflammation), bronchitis, septic arthritis, abdominal abscess, cellulitis (i.e. s"in infection), osteomyelitis (i.e. bone infection), wound infection, pneumonia, foot abscess, le! ulcer, diarrhea, sinusitis, and sepsis (i.e. an infection in the blood), !astroenteritis (i.e. infection of the stomach and intestines), tuberculosis $n%ection site reactions # includes mild to moderate erythema (i.e. redness) and#or itchin!, pain or swellin!$ bleedin! and bruisin! at the in%ection site &alignancies 'Cancers( # includin! lymphomas such as non-&od!"in's lymphoma, colon cancer, breast cancer, lun! cancer, prostate cancer, non-cutaneous solid tumors, basal cell s"in cancer and s(uamous cell s"in cancer
• •
• •
Enbrel Side Effects &edium re!uency of "ccurrence
• • • • • • • • • • • • • • • •
Abdominal pain Alopecia Asthenia % !eneral wea"ness#loss of stren!th -ough +i,,iness +yspepsia Headache 2outh ulcer 5ausea @eripheral edema % swellin! in the arms and le!s @haryngitis % sore throat ;ash ;espiratory disorder ;hinitis % runny nose 3inusitis % sinus infection#inflammation 1omiting
Enbrel Side Effects )o* re!uency of "ccurrence
• • • • • • • • • • • • •
Appendicitis "ursitis % inflammation of the bursae -erebral ischemia % insufficient blood flow to the brain -holecystitis % inflammation of the !allbladder +eep vein thrombosis +epression +yspnea % difficulty breathin! /astrointestinal bleeding Heart failure Hypertension % hi!h blood pressure Hypotension % low blood pressure Aidney calculus % "idney stones =ymphadenopathy % enlar!ed lymph nodes ()swollen !lands))
• • • • • • • • • • • • •
2embranous glomerulonephropathy % a type of "idney disorder 2ultiple sclerosis 2yocardial infarction 2yocardial ischemia 5ormal pressure hydrocephalus % an increase in pressure in the brain caused by e*cessive fluid in the brain @ancreatitis % inflammation of the pancreas @olymyositis % wea"ness and inflammation of the muscles @ulmonary embolism % blood clot in the lun!s 3arcoidosis 3ei,ure 3troke 4hrombophlebitis % a blood clot in a vein 6orsening psoriasis
Adverse in Children *ith +uvenile $diopathic Arthritis '+$A(
re!uently "ccur,
• • • •
Abdominal pain Headache 5ausea 1omiting
Sometimes "ccur,
• • • • • • • •
-utaneous ulcer % s"in ulcer +epression7personality disorder !sophagitis7gastritis /astroenteritis /roup A streptococcal septic shock 3oft tissue and post%operative wound infection 4ype ) diabetes mellitus 1aricella % chic"en po*
Post#&ar-eting Enbrel Side Effects
4he following !nbrel side effects were reported A:4!; !nbrel was approved and being used by the general population. >ou should note though that they were reported voluntarily by folks in the general population so there is therefore no way to determine how often they occur or if there is even really a true connection between them and !nbrel. Adults
• • • • • • • •
Adenopathy % enlar!ed#swollen lymph nodes Altered sense of taste Anemia Angioedema Anore8ia % loss of appetite Aplastic anemia % failure of the bone marrow to produce blood cells Autoimmune hepatitis -entral nervous system events suggestive of multiple sclerosis or isolated demyelinating conditions such as transverse myelitis inflammation of the nerves of the
• • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • •
spinal cord or optic neuritisinflammation of the optic nerve i.e. the nerve that (simply put) connects the eye to the brain -hest pain -utaneous vasculitis % inflammation of the blood vessels in the s"in +iarrhea +ry eyes +ry mouth +yspnea % difficulty breathin! !rythema multiforme % red, blistery rash :atigue :ever :lu syndrome /enerali,ed pain Interstitial lung disease % inflammation#swellin! of the lun!s that can cause scarrin! Intestinal perforation Boint pain =eukopenia % a type of low white blood cell count =upus%like syndrome with manifestations including rash consistent with subacute or discoid lupus 5eutropenia a type of low white blood cell count 5ew%onset congestive heart failure <cular inflammation % eye inflammation @ancytopenia abnormally low levels of all types of blood cells @aresthesias % numbness or tin!lin! of the s"in @ruritus % itchin! @ulmonary disease % lun! disease 3ei,ures 3tevens%Bohnson syndrome 3troke 3ubcutaneous nodules % lump#lesion#mass under the s"in 4hrombocytopenia % low blood platelet count 4o8ic epidermal necrolysis % blisterin!#peelin! of the top layer of the s"in (can be lifethreatenin!) 9rticaria % hives$ itchy rash 1asodilation (flushing) 6eight gain 6orsening of prior lung disorder
Children
• • • • • • • • •
Abscess with bacteremia % abscess with a bacterial infection of the blood -oagulopathy % a condition that affects the normal clottin! of the blood -utaneous vasculitis % inflammation of the blood vessels in the s"in <ptic neuritis % inflammation of the optic nerve i.e. the nerve that (simply put) connects the eye to the brain @ancytopenia % abnormally low levels of all types of blood cells 3ei,ures 4ransaminase elevations % there are en+ymes produced by the liver 4uberculous arthritis % infection of the %oints due to tuberculosis 9rinary tract infection
http://www.drug-side-effects-and-clinical-trials.com/enbrel_side_effects.html
