Immunocompromise State in Pregnancy 2013

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IS PREGNANCY AN UNCOMPROMISED STATE ? Dato’Dr.Ghazali Ismail

Consultant Obstetrician Gynaecologist Hospital Sultan Ismail, JB

DEFINITION : AN UNCOMPROMISED STATE • Uncompromised is Uncompromised is define as able to function optimally, especially with regard to immune response, owing to underlying disease, harmful environmental exposure, or the side effects of a course of treatment •  A person who has an immunodeficiency immunodeficiency of any kind is said to be immunocompromised immunocompromised.. •  An immunocompromised person may be particularly vulnerable to opportunistic infection in addition to normal infections that could affect everyone.

INTRODUCTION •

 

The immune system is defined as body’s defense mechanism for fighting disease and infection. • The immune system produces antibodies and special cells that attack viruses and microorganisms. • The inbuilt immune system within the body enables it to recognize materials as foreign objects andor thus neutralizes, eliminate or metabolize them with without injuring its own tissues.

Components of the immune system  system  Innate immune system  system  Response is non-specific

Adaptive immune system  system  Pathogen and antigen specific

Exposure leads to immediate maximal response

response Lag time between exposure and maximal response

Cell-mediated and humoral

Cell-mediated and humoral

components

components Exposure leads to immunological memory

No immunological memory Found in nearly all forms of life

Found only in jawed vetebrates

• Our immune system is volatile and can be influenced by variety of factors. • Immunity system is suppressed during pregnancy to accept semi-allogenenic fetus • Pregnant woman is more prone to infection and diseases which may have implications on her own health as well as for the developing fetus

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