LASIK for Myopia

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LASIK for Myopia and Astigmatism: Safety and Efficacy

LASIK (laser in situ keratomileusis) is a surgical procedure designed to correct refractive errors by using laser light and intended to reduce a person's dependency on glasses or contact lenses. LASIK involves creating a corneal flap using a microkeratome (Figure 1), permanently reshaping the cornea using an excimer laser to remove tissue from the underlying stromal bed and then replacing the flap. The cornea is the clear/transparent film in the front of the eye that lies just in front of the coloured part which is the iris. The cornea allows light to enter the eye and also refracts/bends the light and focuses it at the back of the eye which is the photosensitive area called the retina. The cornea is a part of the eye that helps focus light to create an image on the retina. The bending and focusing of light is also known as refraction. Usually the shape of the cornea and the eye are not perfect and the image on the retina is out-of-focus (blurred) or distorted. If
there is a problem with the shape of the cornea, the light focuses in front of and not exactly on the retina and this doesn’t allow you to clearly see objects that are away from you.These imperfections

in the focusing power of the eye are called refractive errors. There are three primary types of refractive errors:
  

Myopia: persons with myopia, or nearsightedness, have more difficulty seeing distant objects as clearly as near objects. Hyperopia: persons with hyperopia, or farsightedness, have more difficulty seeing near objects as clearly as distant objects. Astigmatism: astigmatism is a distortion of the image on the retina caused by irregularities in the cornea or lens of the eye.

In LASIK surgery, the cornea is properly reshaped by the laser to allow the light to focus on the retina. LASIK surgery can be used for people with mild, moderate or severe myopia.

History of LASIK
LASIK evolved from a variety of techniques in refractive surgery. Keratomileusis, with both freeze and non-freeze techniques was used in the USA in the 1970s. This procedure was followed by automated lamellar keratoplasty (ALK), in which a microkeratome was used to create either a free cap or a hinged corneal flap. Tissue from the corneal bed was removed to alter the refractive error and the flap was replaced. Keratomileusis and ALK were relatively imprecise mechanical techniques. After the ophthalmic excimer laser was developed, it was used to reshape the cornea in a technique called photorefractive keratectomy ( PRK ). LASIK combines the technique of creating a hinged corneal flap from ALK with excimer laser ablation from PRK (Figure 2). Potential advantages of LASIK over PRK include earlier postoperative stabilization and faster improvement of visual acuity; less postoperative patient discomfort; shorter duration of postoperative medication use; and an easier enhancement procedure.

LASIK Indications for the Correction of Myopia and Astigmatism
LASIK is indicated for the correction of low, moderate, and high myopia with and without astigmatism. The specific dioptric limits depends on the specific laser system and the regulatory agency of each country. In the U.S.A. the approved indications can be found on the Food and Drug Administration (FDA) labeling. The correction of high myopia may present a greater risk of post-LASIK ectasia and decreased quality of vision in some patients. The surgeon and patient should decide whether LASIK is indicated based on a full preoperative evaluation and consideration of goals and alternatives, including spectacles, contact lens, and phakic intraocular lens implantation. It's not indicated for people who:
  

are aged less than 18 years. have not had stable vision for at least one year. have any other diseases of the cornea.

Preoperative Evaluation
Preoperative evaluation should include a complete eye examination, a full medical and ophthalmologic history, and informed consent. Dry and cycloplegic refraction should be performed for all patients. Rigid contact lenses should be removed for several weeks and soft lenses for several days to weeks before examination. If you are using contact lenses, you need to
stop wearing them three to four weeks before the operation and use glasses instead. This is because contact lenses affect the shape of the cornea and it needs three to four weeks to revert to its natural shape. If the cornea does not have its natural shape before the operation, the laser cannot reshape it accurately and effectively to provide a successful result

Refraction should be stable within 0.5 D for 1 year or more before LASIK surgery. Measurement of corneal topography is essential, and is used to screen for irregular astigmatism, keratoconus and forme fruste keratoconus which are associated with unpredictable refractive outcomes and progressive ectasia (bulging of the cornea) after LASIK. Measurement of corneal thickness is also critical in the preoperative assessment for LASIK because of its importance in the calculation of anticipated residual stromal bed thickness. A thin cornea may also be an indication of subtle keratoconus, and indicates a need for caution in tissue removal. Other tests which should be performed include measuring pupil size and eye movements.

Contraindications to LASIK
Fuchs corneal endothelial dystrophy, corneal epithelial basement membrane dystrophy, peripheral retinal tears, especially in highly myopic eyes, systemic autoimmune disease, pregnancy, lactation, severe dry eyes, and significant blepharitis which should be treated prior to surgery.

Flap Thickness

LASIK flaps are cut with either mechanical microkeratomes or femtosecond lasers. Mechanical microkeratomes are typically labeled for nominal cut depths of between 120 and 180 µm. There is a trend to cut thinner flaps with the newer microkeratome models, which are more precise. Thinner flaps preserve greater stromal bed thickness and reduce the risk of ectasia. Femtosecond lasers tend to create more precise and uniform flap thickness, and settings of 100-120 µm are typically used. A residual posterior stromal thickness of at least 250 μm is recommended to reduce the risk of post-LASIK ectasia. Some surgeons also believe that the stromal bed should be at least half of the original corneal thickness. To help ensure an acceptable final postoperative residual stromal thickness, flap thickness can be measured by intraoperative ultrasound pachymetry. Anterior segment optical coherence tomography (OCT) can be used to measure flap and stromal bed thicknesses (Figure 3). Flap thicknesses can deviate significantly from the nominal setting and routine measurement can help the surgeon evaluate the range of actual thickness obtained.

Surgical Technique
Before surgery the excimer laser, suction ring, microkeratome and blade (or femtosecond laser settings), are checked by the technician and the surgeon. The surgeon also confirms that the correct treatment data are entered into the laser computer. An eyelid speculum is placed in the operative eye, which has been anesthetized with drops, and the fellow eye is covered. The cornea is marked to aid in postoperative flap alignment. A suction ring is placed on the eye to achieve fixation. The microkeratome (or femtosecond laser) is used to create a hinged corneal flap. After the flap has been created, it is reflected away from the cut surface. Excimer laser ablation is performed, centered on the pupil. Eyetracker and iris registration technology are increasingly used to ensure a well-centered laser treatment. Following the excimer laser, the flap is replaced.

Postoperative Care
Patients may have mild postoperative discomfort for 4 to 6 hours following LASIK treatment, during which time they should keep their eyes closed and rest or take a nap. Patients should not rub their eyes after surgery. Steroid and antibiotic drops are used for 4 to 10 days after surgery. Preservative-free tears may be used for weeks to months depending on dry eye symptoms and corneal punctate staining. You can wash, bathe, or shower normally after the
operation, but you must not get water in your eye for a month. If you have your hair washed, have it done with your head leaning backwards. Do not use makeup on your eyelids for one month.

Refractive stabilization for myopes take up to 3 months depending on the amount of treatment performed. Residual refractive error can be corrected after stabilization, typically by relifting the flap and ablating the stromal bed in a retreatment procedure (also called an enhancement). To ensure preservation of at least 250 μm of residual bed thickness after laser retreatment, preoperative OCT or intraoperative ultrasound pachymetry could be performed.

Outcomes of LASIK for Myopia and Astigmatism
For the correction of low to moderate myopia of less than -6D and low to moderate astigmatism of less than 2D, results from studies in the literature have shown that LASIK is effective and predictable in terms of obtaining very good to excellent uncorrected visual acuity and that it is safe in terms of minimal loss of visual acuity. For higher degrees of myopia and astigmatism, the results are more variable.

LASIK Complications
Complications occur in LASIK as in any other surgical procedure. Serious adverse complications leading to significant permanent visual loss occur rarely. Less serious side effects such as dry eyes, night time starbursts, and/or reduced contrast sensitivity occur relatively frequently. The most common complication or side effect following LASIK is dry eyes. Complications involving the LASIK flap include free, incomplete, or buttonholed flaps, striae/folds or slipped/displaced flaps. If the flap created during the LASIK procedure is irregular, incomplete, or buttonholed, laser treatment cannot safely be performed in the same session. However, after a healing period, a secondary LASIK or PRK procedure may be performed in some cases. Complications that occur at the level of the interface between the flap and the stromal bed include diffuse lamellar keratitis, infection, and epithelial ingrowth. Post-LASIK ectasia may occur as a result of a residual stromal bed that is too thin or from an inherent predisposition of the cornea to distortion. It is uncertain if there is any relationship between LASIK and an increased incidence of postoperative retinal detachment. Ischemic optic neuropathy is a rare complication that has been reported following LASIK. LASIK Eye Surgery

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