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678 BiologyWhy does a muscle seem to sometimes go crazy and just pulse with seemingl y random contractions and relaxations? self.askscience submitted 4 hours ago by MikeW86    

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all 91 comments sorted by: best []DEATH-OF_RATS 88 points 1 hour ago This is  broken Neurons cies at

a neural thing ("neural" as in "related to nerve tissue," not "something in your brain"). Basically, muscles activate when activated by neurons. activate by letting certain ions pass through the membrane. The main spe work are sodium, chlorine, and potassium. There are a few others, but th

 

ese are the main ones. Each muscle/neural cell has channels through the cell wal l that selectively allow each species to pass. (So, one channel type only lets p otassium pass, another only lets sodium pass...) Each channel's resistance to its particular ion type is a function of the voltag e across the membrane (cell wall). That is, as the voltage across the membrane c hanges, so does the membrane's permittivity to each ion. And the channels for th e different ions respond to the trans-membrane voltage in different ways. Given time in a stable system, these three species will find a balance point created b y the concentration of the ion outside the cell relative to the concentration of  the ion inside the cell, and the voltage the relative concentrations set up. Re member, these are charged particles, so if there are unequal numbers on the two sides, there will be a voltage across the membrane (this just means there is a d ifferent of The charge accumulated one side of it compared to -80 the other si de). Thisamount happens. resting voltageon across the membrane is about mV. The motor unit is the last neuron in the activation chain, the one that connects  directly to a group of muscle fibers (so, brain>spinal cord>motor unit>muscle).  When a neuron or motor unit fires, it is a result of the voltage across the mem brane being forced to a certain level away from its normal equilibrium point (ar ound -40 mV? don't quite remember). This changes how the ions can pass through t he membrane, and because of the nature of this change, lots of ions flow and it results in an "action potential" or "spike" - another name for the neuron firing . A spike is pretty quick, only a couple milliseconds. (Neurons pass information  this way - when one neuron is connected to a group of neurons that fire at abou t the same time, the connections are such that these other neurons' action poten tials change the membrane voltage of the downstream neuron enough that it, in tu rn, fires, and so on.) These random muscle twitches happen when there's some kind of random uneven buil dup of the relevant ion species around a motor unit (I'm not sure, but it probab ly also works if it's around actual muscle fibers, or maybe even some spinal cor d neurons that are within one or two connections of the motor unit). This can ar tificially change the membrane voltage (a non-artificial change, in contrast, wo uld be the result of a command from the brain or a spinal cord reflex) and induc e an action potential, activating the downstream muscle fibers. I don't know wha t causes this uneven buildup of ions, but that's how it works once they get ther e. TL;DR Ions involved in neural activation randomly accumulate in an area near the  muscles and artificially create a response that normally only comes about due t o signals from the brain. They seem random because they are.  

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[]Suckassloser 12 points 1 hour ago Best answer so far. The others have stated stress but not provided a mechanism..  To save people some time since its quite a long answer, I'll point out the last  paragraph (before the tl:dr) is the most relevant; particular for those who are  already aware of what action potentials are etc.    

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[]21moabit 3 points 43 minutes ago While you depict the underlying physiology of neural activation and action poten tials, your answer is not wholely satisfying as to why there might be shifts in ion concentration-levels. Also, I tend to notice that there are muscles, which t

 

end to twitch more often than others (e.g eyelid, biceps, pec. major). Is that o nly me? Just curious. Thanks anyways for taking the time to answer thoroughly    

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[]j2g7d 1 point 8 minutes ago Its a combination of diet & your body attempting to maintain balance in that par ticular muscle. Your eyelids are particularly susceptible to strain (hours of re dditing) and the muscles you mention I'd imagine are those which you focus on at  the gym?    

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[]pppe 1 point 2 seconds ago I get those muscles too, also the deltoids (almost always just the medial head). Can't comment on why those particular muscles would be affected. However I would  say that it only seems to affect muscles that are relaxed and not extended; doe s being under tension override whatever causes the twitches?    

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[]Cherry_Picked 2 points 17 minutes ago  

randomly accumulate in an area

What about seemingly non random accumulations? Typically after a hard workout (h eavy power lifting), more specifically on my chest, I often find that for a day or two afterwards a may have a 'twitch' that pulses throughout the day. That see ms more like a targeted build up of neural activity - as in there appears to be a direct cause... why would a build up of neural activity be non random?    

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[]DEATH-OF_RATS 2 points 6 minutes ago Good point. I don't know the mechanisms that cause the buildup, I'm afraid, but I wouldn't be surprised if exertion plays into it.    

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[]Czar_Castic 1 point 1 hour ago Great in-depth. Thanks.    

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[]I_am_not_a_bot 1 point 18 minutes ago Where and how are the neurons sourcing the ions?  

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[]DEATH-OF_RATS 1 point 2 minutes ago Vaguely speaking, from the blood. I know that in the brain there are other cells  in charge of supplying neurons with nutrients (glial cells for example supply g lutamate and I think a couple other chemicals), but that's about all I know. In general, ions are distributed through the extracellular (and intracellular) flui d all throughout your body, so I assume it's carried there by the blood from you r digestive system. Sorry, my training is systems-level neuroscience, not in-depth physiology (so, w e learn "this is basically how neurons work, okay lets go do math about how they  respond tothis inputs", instead ofcells "these are all chemicals and where they come  from, and is how all the respond tothe them").    

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[]ThatsObvious 174 points 3 hours ago Muscle spasms/twitches can be caused by numerous things. Usually it's either due  to stress, fatigue, dehydration, or a nutrient/vitamin deficiency. Spasms and twitches can also be caused by neurological issues or nerve issues.  

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[]not-a-ginger 68 points 3 hours ago I've always wondered... how exactly does stress cause physical problems? So, I'm  really stressed right now and my leg is twitching... what's the physiologic pro cess that's making that happen?    

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[]ThatsObvious 58 points 2 hours ago When you are stressed/have anxiety it's not just a feeling. Your body changes wh en stressed. It can increase blood pressure and cause blood vessels to constrict  as well as speed up breathing. Why does it cause things like muscle spasms? I h ave no idea.    

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[]eaturfeet653 30 points 2 hours ago I'm not 100% on this, but it could be due to the epinephrine neurotransmitters a nd cortisol hormones around the neuromuscular junction. Both tend to stimulate t he sympathetic nervous system which is geared towards your flight or fight respo nse and energy consumption. A large build of of these chemicals in localize area s could cause increase frequency of action potentials which could translate to i rregular muscle contractions    

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[]macthewackbitch 8 points 2 hours ago

 

What I've always been curious about is why your body seems to take on the sympto ms of stress when you'r mind/emotions stay relatively unaffected. Like, sometime s i'll have symptoms such as muscles twitching, acne, increased sleep, etc. but mentally i'll feel completely normal. Like my body is compensating for my mind o r something. I could be wrong though and its all a result of something else. Or i'm just horribly repressed.    

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[]Nerfi 10 points 1 hour ago We're still builtexaggeration). for making wood lean-tos will and running from Mastadon stampe des (intentional Evolution catch upaway to our advanced lifestyl e, until then you should expect some bugs in the code while we adapt to the tran sition.    

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[]Machegav 5 points 42 minutes ago I actually doubt this. In what way are those things being selected against? More  to the point, despite the relatively low chance of having a fight-or-flight res ponse actually mattering for you eventually passing on your genes, a small advan tage is still an advantage.    

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[]FearTheCron 2 points 23 minutes ago http://www.npr.org/2013/09/27/226837803/modern-humans-still-evolving-an http://www.npr.org/2013/09/27/226837803/modern -humans-still-evolving-and-fasterd-fasterthan-ever This was a really interesting piece on modern human evolution.    

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[]Nerfi 1 point 26 minutes ago While it may take thousands of years, subtle traits beneficial to life unprotect ed by society, such as an increased propensity for aggression, will be slowly we eded out as a process of intentional selection becomes more a more apparent resu lt of our newfound (it really hasn't been that long, please don't assume I'm ass ured of this hypothesis) ability to actively predict cause-effect relations. Mor eover, natural selection still applies, as those more socially adept, rather tha n physically, become dominant in procreation, a complexity that as far as I'm aw are is not accounted for in current interpretations of natural selection.    

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[]chopachulas 3 points 39 minutes ago I wouldn't just assume that evolution will catch up. There has to be a mechanism  for natural selection to occur. ie, people who exhibit these symptoms when they 're stressed have to be less likely to reproduce. It's hard for me to believe th

 

at you won't mate just because you occasionally have twitching muscles, acne, in creased sleep, etc when you're stressed out.    

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[]Nerfi 1 point 19 minutes ago Sorry, I didn't mean to declare it as an assumption, but merely as what I see to  be the probable path of the effect intelligence and causal reasoning newly intr oduced (by our species) to the natural selection paradigm. I didn't mean to impl icate muscular tics in particular as an undesirable trait, but only the violent "fight or flight" responses bred into us by millenia of the oppressive pressures  of endlessIcycle of self-consumption by manner organicin beings. It's late and I've b een an drinking, apologize for the atrocious which I've attempted to co nvey this idea.    

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[]thesilverblade 1 point 46 minutes ago Evolution won't catch up during our lifetimes though. It'll be many generations before there are any noticeable changes.    

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[]blackfredlucy 1 point 28 minutes ago Your body is probably busy doing lots of things your not aware of, things like c ombating infections before you get sick, building or repairing tissues, dealing with hormone pathways, and good old homeostasis. It also needs to have the right  amount of every resource to do these things so if key elements lack it can take  it's toll mounting as stress signs. Stress isn't just a mental thing, its a phy sical burden too. Probably just a sign it's working hard but doing a awesome job  by not dragging you down    

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[]_JerBear_ 1 point 1 hour ago But why would the frequency stop at a twitch and not continue onto tetanus? And the fact that they tend to be localized is weird as well. I'll ask my professor tomorrow and see if I can get an answer.    

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[]Nerfi 0 points 1 hour ago This makes perfect sense to me as a layman with almost no medical or anatomical education. Thank you for such a precise and succinct response, even if it is spe culation, because it helps understanding regardless.    

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[]ScorpionWoman 3 points 1 hour ago

 

Cortisol, the "stress hormone," upregulates the conversion of epinephrine. Your heart and other muscles have epinephrine receptors as part of a sympathetic nerv ous system pathway (fight or flight), and increase in epinephrine causes increas ed activity in these muscles. In the heart, epi causes increased heart rate and more forceful contractions. Vasodilation (due to the relaxation of the smooth mu scle layers in arteries) also occurs as a result of epinephrine, but only in cer tain muscles. This ensures that your blood is shunted to muscle groups needed fo r flight or flight (legs, arms, brain) and not to the stomach or secondary sexua l organs. No idea about twitches, though. A different neurotransmitter is used f or neuromuscular junctions (acetylcholine), and it upregulates cortisol, but I'm  not sure about twitches.    

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[]WallyMetropolisStatisti ]WallyMetropolisStatistical cal Physics | Granular Physics | Emergence | Chaos 17 po ints 1 hour ago Yes, but how does, say, dehydration result in a muscle twitch?    

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[]aclonedsheep 19 points 1 hour ago Changes in intracellular and extracellular electrolyte concentrations, probably mostly Sodium.    

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[]Lub_dubb 10 points 1 hour ago If you exercise often it is most likely a potassium deficiency. Whenever I twitc h I eat a banana (a high source of potassium) and it stops the next day.    

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[]WallyMetropolisStatisti ]WallyMetropolisStatistical cal Physics | Granular Physics | Emergence | Chaos 7 poi nts 1 hour ago This is only helpful if I already knew how electrolytes affected muscles, which I don't.    

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[]jimman131412 6 points 1 hour ago Took a class that covered this while in college, a huge number of processes in t he body rely on electrolytes crossing cellular membranes to transport an action potential. If you are low on some of these electrolytes (Na, K, and for muscles Ca) being the main 3 this can cause action potentials to not travel properly and  cause twitches or cramps and relating back to dehydration when these electrolyt es move water crosses the membrane to be where the concentration of solutes (ele ctrolytes in this case) are highest so that's how dehydration plays a role.  

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[]EdgarAllanNope 3 points 1 hour ago In the simplest terms, the nerve receives a signal, sodium flows in, then potass ium flows out. This is the "signal" flowing down the nerve like a wave. After th e signal has been sent, sodium gets pumped out and potassium gets pumped back in . If concentrations of sodium or potassium are not within a certain range, you'l l start having issues    

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[]duckconference 1 point 46 minutes ago Ass it turns out, dehydration probably does not cause muscle cramps. The easiest  citation to find was this one: http://www.ncbi.nlm.ni http://www.ncbi.nlm.nih.gov/pmc/articles/PMC172 h.gov/pmc/articles/PMC1724 4 901/ but there a lot more, especially if you look at the work of T Noakes who is one of the authors of that paper and has done a lot to advance our understanding of dehydration during exercise.    

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[]SicilSlovak 4 points 3 hours ago Also a possible side effect of many medications (especially stimulants).    

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[]spazmodic- 4 points 1 hour ago and don't forget that caffeine is a stimulant (I know it's obvious, but the obvi ous is often overlooked)    

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[]ryhann 1 point 1 hour ago I had this and I'm thinking it was related to either fatigue or dehydration. do you think you could elaborate on how they make the muscle twitch. and/or why? an d/or how to make it stop    

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[]InsaneSensation 1 point 1 hour ago What about on surgery scars?    

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[]baculaat 1 point 1 hour ago by "stress", do you mean physical stress to the body due to exercise or also due

 

 to emotional stress? I often get muscle twitches around my chest if I´ve jogged f or a long time.    

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[][deleted] 3 hours ago []Kinggert 0 points 2 hours ago* I'm still an undergrad, but in physiology today, we learned about some hypothesi s that sometimes the brain likes to self regulate/monitor things. It may make yo ur leg itch or hand twitch just so you grab it and your brain recognizes it is s till there. Just an idea we learned.    

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[]tentaakel 3 points 1 hour ago First, what you learned is probably wrong, and second, it's not a theory, it's a  hypothesis (there is a difference!). "A hypothesis is either a suggested explanation for an observable phenomenon, or  a reasoned prediction of a possible causal correlation among multiple phenomena . In science, a theory is a tested, well-substantiated, unifying explanatio explanation n for  a set of verified, proven hypotheses. A theory is always backed by evidence; a hypothesis is only a suggested possible outcome, and is testable and falsifiable ."    

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[]Fozee 0 points 1 hour ago There's a proposed sense, the name of which I don't remember, which supposedly m akes it so that you know where all of your limbs are even without being able to see them. As an extension of what you said, perhaps it's the way that sense gets  tuned.    

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[]Kinggert 2 points 1 hour ago Perhaps proprioception? I'm pretty sure that has something to do with body sense  and posture.    

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[]BrandonTheTerrible 1 point 1 hour ago Proprioception relies on proprioceptor nerve cells which are embedded in the joi nts. It has been shown that these are much less important than the stretch recep tors in n muscle spindle fibers and stretch receptors in the skin for determinin g joint position and velocity. Also, in case you never noticed, it is very difficult to tell the position of a limb without some movement or external reference. Try this: sit in a luke-warm p

 

ool with no current moving. Let your legs dangle. After a few minutes, you'll lo se track of their location. Your senses aren't absolute, they're relative. When you sit still, they forget where you are.    

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[]SnowySnurfer 4 points 1 hour ago ThatsObvious has got down the cause of muscle spasms pretty much spot on, but th e pathology of muscle innervation may still be holding back your understanding o f the spasms. So muscles contract through a signal being sent from your brain to the muscle th rough motor neurons. The signal is called an action potential which is basically  an electrical gradient of increased negativity cascading through these motor ne urons. The electrical signal of this action potential is dependent on the correc t balance of ions in the fluid within the neurons.Once this signal reaches the m uscle, a neurotransmitter called acetylcholine "tells" the muscle to release cal cium. This release allows the proteins of the muscle to contract. This whole series of events is much more complicated than I have described (crud ely), but all that it really means is that muscle contraction is based on a mult itude of different events in a series. When one part of the process is interrupt ed by an incorrect balance of ions (nutrient/vitamin defiency or dehydration), m icro-tears in the muscle (fatigue), or imbalances of hormones (stress), the musc le can make a mistake. tldr: your body is like a fine tuned machine, even if everything seems/feels rig ht a small inconsistency can lead to a misstep.  

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[]BrandonTheTerrible 10 points 3 hours ago* I'm a Feldenkrais Practitioner. We work with the low-level coordination of the m uscles by developing greater awareness of movement. In some of the more mentally  challenging lessons, people will experience this. These people aren't patients for any medical condition that I know of. However, they are engaged in actively reshaping the brain's control over the muscles in question. So instead of a phys iological issue, sometimes it can be simply that somewhat spurious signals are l eaving the brain via the usual pathway- the efferent nervous system - and the mu scles are responding normally. Simply saying that a twitch in a single muscle (we have hundreds, and they mostl y come in pairs) is caused by stress, fatigue, dehydration, or a nutrient/vitami n deficiency neglects that at that instant, the person has hundreds of muscles N OT doing that. These other muscles are in pretty much the same conditions as the  one experiencing the twitch, except for fatigue. EDIT: Apparently my last statement "These other muscles are in pretty much the s ame conditions as the one experiencing the twitch, except for fatigue. " is cont entious. I'll defer to folks with more physiology training on that particular as pect.  

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[]aclonedsheep 4 points 1 hour ago  

Simply saying that a twitch in a single muscle (we have hundreds, and they m

 

ostly come in pairs) is caused by stress, fatigue, dehydration, or a nutrient/vi tamin deficiency neglects that at that instant, the person has hundreds of muscl es NOT doing that. These other muscles are in pretty much the same conditions as  the one experiencing the twitch, except for fatigue. There is more local variability than you realize. It isn't as if all muscles rec eive the same amount of blood at the same time, and that they are all under the same amounts of stress.    

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[]h8mx 2 points 1 hour ago Not to mention each muscle has its own size, nutritional needs, blood vessels, i nnervation, and even nerves themselves can differ in their excitability threshol d, for instance. If you're stressed and the microvessels closer to a muscle coll apse that muscle will get more affected than the others in terms of O2 and nutri ents perfusion.    

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[]BrandonTheTerrible 1 point 1 hour ago  

If you're stressed and the microvessels closer to a muscle collapse

So in this case are the microvessels (I assume that means larger than capillarie s) collapsing due to stress hormones, mechanical compression, or is this control led by the nervous system?    

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[]h8mx 1 point 36 minutes ago There are a number of factors at play. Your vessels have smooth muscle so your b ody can control the vascular tone. When you're stressed your nervous system rele ases hormones such as epinephrine/adrenaline which generally causes your vessels  to constrict and less blood to flow, with the exception of the brain and heart so you can fight or run. The nervous system can also influence muscle metabolism  and contractility which are generally increased. Then there are local factors a t play which can "overwrite" the systemic response. When muscles are activated t hey function kind of like a pump thus increasing their blood flow. Ischemia mean s the muscle isn't getting enough food and oxygen and thus it releases its own h ormones and chemicals to increase local blood flow. Atherosclerosis means thicke r vessels and less blood. Just listing some of the factors that I remembered, it's been a while ago. I apo logize if my English is not that good.    

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[]BrandonTheTerrible 1 point 1 hour ago Thanks. I edited my post. Just curious, to what are you referring when you say " that they are[n't] all under the same amounts of stress. " Are you talking about emotional stress (which muscles don't experience themselve

 

s I don't think), fatigue (which they do experience), mechanical compressive str ess, or effects due to stress hormones in the blood?    

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[]aclonedsheep 1 point 1 hour ago I meant mechanical/hormonal/chemical stress, but emotional stress can certainly affect all of those things indirectly (Weight of the world posture, hyperglycemi a, etc)  

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[]aclonedsheep 1 point 1 hour ago BTW, how does Feldenkrais differ from Alexander technique?    

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[]BrandonTheTerrible 1 point 1 hour ago I'm il. est hat

not too sure, Alexander technique was discussed a few times, but not in deta I think the main difference is that in Feldenkrais, each person is his own b gauge for what feels good or right for himself at that time. In Alexander, t isn't the case (if memory serves).

Also, in Alexander, it is a sin to close your eyes in order to focus more clearl y on the relevant stimulus. In feldenkrais, this is encouraged, especially for n ewcomers, as it makes the internal senses more clear.    

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[]FresnoRog 1 point 1 hour ago   So instead of a physiological issue, sometimes it can be simply that somewha t spurious signals are leaving the brain via the usual pathway- the efferent ner vous system - and the muscles are responding normally. I find this part confusing. Could you distinguish between a physiological issue and how the brain sends signals to muscles?    

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[]BrandonTheTerrible 1 point 1 hour ago The way I mean it, a the muscle or in the s it from responding ever) that makes the

physiological issue would be some off-nominal chemistry at efferrent nervous system on the way to the muscle that keep normally. This would be a dearth of potassium ions (or what nerves fire intermittently.

What I'm talking about is essentially confusion in the Central nervous system (n ot the efferrent nervous system). The brain isn't sure just how to control the m uscle because some of its mappings (desired movement A means fire neurons C,D, a nd G) are in disarray while the brain is learning to do things differently. This  conflict between various firing patterns often causes muscle twitching in the a

 

rea being targeted. For example, I could give you some very small movements to perform (so small tha t fatigue wouldn't be an issue) and following that, there's a really good chance  your intercostal muscles would twitch like crazy for an hour or so. There may b e more happening here than the brain sending out spurious signals, of course.    

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[]UrbanPlannerr 1 point 41 minutes ago Potassium. Potassium is something people do not get enough off, but that is beca use it is hard to take the daily dosage. Too much potassium at once is very dangerous and spreading it out throughout the  day is very hard to do. Not impossible, but hard to do on an even keel througho ut the day. Some professionals actually advocate for multivitamins to fill deficiencies; How ever, I'm neutral when it comes to whether the effectiveness of multivitamins ac tually work.  

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[]ProfessorFood 1 point 11 minutes ago Rarely, these muscle spasms (fasciculations) you're talking about may be signs o f motor neuron damage. If these spasms are confirmed my electromyelograph readin gs, and they are accompanied by clinical muscle weakness and brisk reflexes with  clonus, they could indicate ALS.  

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[]Whitedragon86 0 points 1 hour ago I took lexapro for my depression for like 3 years, since then I have at least 3 noticeable muscle spasms a day (had it on a glute muscle once lol). I also have restless leg syndrome that can act up anywhere on my body. The worst is the feeling of RLS in the chest at night. Only thing that seriously cured my RLS 100% was taking piracetam Dailey. I cannot explain why.  

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