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Content
Pregabalin is an anticonvulsant drug used for neuropathic pain and as an adjunct therapy for partial
seizures with or without secondary generalization in adults. Recent studies have shown that pregabalin
is effective at treating chronic pain in disorders such as fibromyalgia and spinal cord injury.
Methylcobalamin is the neurologically active form of vitamin B12. Vitamin B12 comes in several kinds
including hydroxy, cyano, and adenosyl, but only the methyl and adenosyl forms are active within the
body. Methylcobalamin donates methyl groups to the myelin sheath that insulates nerve fibres and
regenerates damaged neurons. In a B12 deficiency, toxic fatty acids destroy the myelin sheath but
high enough doses of B12 can repair it. Animal studies have shown that high doses of
Methylcobalamin are effective in neuron regeneration and that there is no known toxicity at these
doses.
It has been demonstrated by recent studies that combination of Pregabalin and
Methylcobalamin shows significantly better symptoms relief with the modest improvement
of nervous system, chronic pain, perioperative pain, migraine and enhances immune system
function.
Indications and Usage:
+ It is used for neuropathic pain associated with spinal cord injury.
+Diabetic peripheral neuropathy.
+Treatment of fibromyalgia.
+It is also used for treatment of chronic pain, perioperative pain, and migraine.
+Supports the nervous system
+Helps memory and learning
+Boosts energy
+Helps control homocysteine levels
+Promotes a healthy cardiovascular system
+Enhances immune system function
+Effectively supports brain and nerve function.
Drug Interactions:
BEFORE TAKING THIS MEDICINE TELL THE DOCTOR ABOUT ANY MEDICAL PROBLEMS AN
ALLERGIES THAT PATIENT HAS NOW OR HAS HAD.
Usually drug interactions occur when it is taken with another drug or with food. Before you take a
medication for a particular ailment, you should inform the health expert about intake of any other
medications including non-prescription medications.
Mechanism of action:
Combination of Pregabalin and Methylcobalamin not only decreases the release of neurotransmitters
but also helps in regeneration of the myelin sheath. Pregabalin also has got analgesic activity which
reduces the pain associated with neuropathy. Thus the combination of Pregabalin and Methylcobalamin
is useful for arresting the progress of diabetic neuropathy and also helps in relieving the pain
associated with neuropathy. Methylcobalamin is a co-factor of methionine synthase, an enzyme that
transfers methyl groups to homocysteine to regenerate methionine. Elevated homocysteine levels are
a risk factor for coronary artery disease. Methionine can be transformed to S-adenoxylmethionine
(SAM) that is involved in a variety of methylation reactions in the body, one of which is alleviating
depression.
Pharmacodynamics:
It binds to the α2δ (alpha2delta) subunit of the voltage-dependent calcium channel in the central
nervous system. It help to decreases the release of neurotransmitters including glutamate,
norepinephrine, substance P and calcitonin gene-related peptide. However, unlike anxiolytic
compounds (e.g., benzodiazepines) which exert their therapeutic effects through binding to GABA, and
benzodiazepine receptors. It neither binds directly to these receptors nor augments GABA currents or
affects GABA metabolism. The half life for pregabalin is 6.3 hours.
Pharmacokinetics of Pregabalin:
Absorption:
Pregabalin is rapidly absorbed when administered on an empty stomach, with peak plasma
concentrations occurring within one hour. Pregabalin oral bioavailability is estimated to be greater than
or equal to 90% and is independent of dose. The rate of pregabalin absorption is decreased when
given with food resulting in a decrease in Cmax by approximately 25 to 30% and a delay in Tmax to
approximately 2.5 hours. Administration with food, however, has no clinically significant effect on the
extent of absorption.
Distribution:
In humans, the volume of distribution of pregabalin for an orally administered dose is approximately
0.56 L/kg and is not bound to plasma proteins.
Metabolism:
Pregabalin undergoes negligible metabolism in humans. Approximately 98% of the radioactivity
recovered in the urine was unchanged pregabalin. The major metabolite is N-methyl pregabalin.
Excretion:
Pregabalin is eliminated from the systemic circulation primarily by renal excretion as unchanged drug.
Renal clearance of pregabalin is 73 mL/minute.
Pharmacokinetics of Methylcobalamin:Mecobalamin is the neurologically active form of vitamin B12 and occurs as a water-soluble vitamin in
the body. It is a cofactor in the enzyme methionine synthase, which functions to transfer methyl
groups for the regeneration of methionine from homocysteine. In anaemia, it increases erythrocyte
production by promoting nucleic acid synthesis in the bone marrow and by promoting maturation and
division of erythrocytes.
Absorption:
Peak plasma concentrations after 3 hr (oral); 0.9 hr (IM); 3 min (IV).
Excretion:
Via urine.
Side Effects:-
+ Dizziness
+Drowsiness
+Dry mouth
+Constipation
Conclusion:
From the above discussion, it can be concluded that Pregabalin and Methylcobalamin tablet
could improve the quality of life with improvement of nervous system, chronic pain,
perioperative pain, migraine and enhances immune system function and responsible for
healthy cardiovascular system.
We are making superior quality of Pregabalin and Methylcobalamin tablet that is used to treat brain
and nerve function and help to increase memory and learning. Our offered tablet is processed using
high grade chemical compounds by our experienced quality controllers that ensure its quality, purity
and chemical properties. Highly treasured among the clients for its reliability, accurate composition,
excellent physical and purity, this tablet is offered to our esteemed clients at the market leading
prices.
Contraindications:
Pregabalin is contraindicated in patients with known hypersensitivity to pregabalin or any of its
components. Vitamin B12 supplementation is generally regarded as safe during pregnancy and
lactation.
Dosage:
Adult: One Capsule daily before food or as directed by the physician.
Storage:
Store at room temperature, 15-30° C (59-86°F). Keep away from moisture.
seizures with or without secondary generalization in adults. Recent studies have shown that pregabalin
is effective at treating chronic pain in disorders such as fibromyalgia and spinal cord injury.
Methylcobalamin is the neurologically active form of vitamin B12. Vitamin B12 comes in several kinds
including hydroxy, cyano, and adenosyl, but only the methyl and adenosyl forms are active within the
body. Methylcobalamin donates methyl groups to the myelin sheath that insulates nerve fibres and
regenerates damaged neurons. In a B12 deficiency, toxic fatty acids destroy the myelin sheath but
high enough doses of B12 can repair it. Animal studies have shown that high doses of
Methylcobalamin are effective in neuron regeneration and that there is no known toxicity at these
doses.
It has been demonstrated by recent studies that combination of Pregabalin and
Methylcobalamin shows significantly better symptoms relief with the modest improvement
of nervous system, chronic pain, perioperative pain, migraine and enhances immune system
function.
Indications and Usage:
+ It is used for neuropathic pain associated with spinal cord injury.
+Diabetic peripheral neuropathy.
+Treatment of fibromyalgia.
+It is also used for treatment of chronic pain, perioperative pain, and migraine.
+Supports the nervous system
+Helps memory and learning
+Boosts energy
+Helps control homocysteine levels
+Promotes a healthy cardiovascular system
+Enhances immune system function
+Effectively supports brain and nerve function.
Drug Interactions:
BEFORE TAKING THIS MEDICINE TELL THE DOCTOR ABOUT ANY MEDICAL PROBLEMS AN
ALLERGIES THAT PATIENT HAS NOW OR HAS HAD.
Usually drug interactions occur when it is taken with another drug or with food. Before you take a
medication for a particular ailment, you should inform the health expert about intake of any other
medications including non-prescription medications.
Mechanism of action:
Combination of Pregabalin and Methylcobalamin not only decreases the release of neurotransmitters
but also helps in regeneration of the myelin sheath. Pregabalin also has got analgesic activity which
reduces the pain associated with neuropathy. Thus the combination of Pregabalin and Methylcobalamin
is useful for arresting the progress of diabetic neuropathy and also helps in relieving the pain
associated with neuropathy. Methylcobalamin is a co-factor of methionine synthase, an enzyme that
transfers methyl groups to homocysteine to regenerate methionine. Elevated homocysteine levels are
a risk factor for coronary artery disease. Methionine can be transformed to S-adenoxylmethionine
(SAM) that is involved in a variety of methylation reactions in the body, one of which is alleviating
depression.
Pharmacodynamics:
It binds to the α2δ (alpha2delta) subunit of the voltage-dependent calcium channel in the central
nervous system. It help to decreases the release of neurotransmitters including glutamate,
norepinephrine, substance P and calcitonin gene-related peptide. However, unlike anxiolytic
compounds (e.g., benzodiazepines) which exert their therapeutic effects through binding to GABA, and
benzodiazepine receptors. It neither binds directly to these receptors nor augments GABA currents or
affects GABA metabolism. The half life for pregabalin is 6.3 hours.
Pharmacokinetics of Pregabalin:
Absorption:
Pregabalin is rapidly absorbed when administered on an empty stomach, with peak plasma
concentrations occurring within one hour. Pregabalin oral bioavailability is estimated to be greater than
or equal to 90% and is independent of dose. The rate of pregabalin absorption is decreased when
given with food resulting in a decrease in Cmax by approximately 25 to 30% and a delay in Tmax to
approximately 2.5 hours. Administration with food, however, has no clinically significant effect on the
extent of absorption.
Distribution:
In humans, the volume of distribution of pregabalin for an orally administered dose is approximately
0.56 L/kg and is not bound to plasma proteins.
Metabolism:
Pregabalin undergoes negligible metabolism in humans. Approximately 98% of the radioactivity
recovered in the urine was unchanged pregabalin. The major metabolite is N-methyl pregabalin.
Excretion:
Pregabalin is eliminated from the systemic circulation primarily by renal excretion as unchanged drug.
Renal clearance of pregabalin is 73 mL/minute.
Pharmacokinetics of Methylcobalamin:Mecobalamin is the neurologically active form of vitamin B12 and occurs as a water-soluble vitamin in
the body. It is a cofactor in the enzyme methionine synthase, which functions to transfer methyl
groups for the regeneration of methionine from homocysteine. In anaemia, it increases erythrocyte
production by promoting nucleic acid synthesis in the bone marrow and by promoting maturation and
division of erythrocytes.
Absorption:
Peak plasma concentrations after 3 hr (oral); 0.9 hr (IM); 3 min (IV).
Excretion:
Via urine.
Side Effects:-
+ Dizziness
+Drowsiness
+Dry mouth
+Constipation
Conclusion:
From the above discussion, it can be concluded that Pregabalin and Methylcobalamin tablet
could improve the quality of life with improvement of nervous system, chronic pain,
perioperative pain, migraine and enhances immune system function and responsible for
healthy cardiovascular system.
We are making superior quality of Pregabalin and Methylcobalamin tablet that is used to treat brain
and nerve function and help to increase memory and learning. Our offered tablet is processed using
high grade chemical compounds by our experienced quality controllers that ensure its quality, purity
and chemical properties. Highly treasured among the clients for its reliability, accurate composition,
excellent physical and purity, this tablet is offered to our esteemed clients at the market leading
prices.
Contraindications:
Pregabalin is contraindicated in patients with known hypersensitivity to pregabalin or any of its
components. Vitamin B12 supplementation is generally regarded as safe during pregnancy and
lactation.
Dosage:
Adult: One Capsule daily before food or as directed by the physician.
Storage:
Store at room temperature, 15-30° C (59-86°F). Keep away from moisture.
