Pandemic - On the Brink (Manual)

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An expansion
for Pandemic by
Matt Leacock
and Tom Lehmann

Is saving humanity too easy? Spice things up with new roles, events, and challenges.
What if one disease is particularly nasty? Or, if a fifth disease is wreaking havoc?
Or, even worse, if that fifth disease is being spread by a hidden Bio-Terrorist?
Welcome to Pandemic: On the Brink!

INFECTIOUS SUBSTANCE
IN CASE OF DAMAGE OR
LEAKAGE IMMEDIATELY NOTIFY
LOCAL HEALTH AUTHORITY

After each player turn, do up to 2 actions,
plus 1 Drive/Ferry action (in any order).

ta
ine
r

MOVE THE INFECTION RATE
MARKER FORWARD 1 SPACE.

with
out

frst o

rvi
bse

ng

is
th

is
th

op
er
s

afe

ty p

recau
t

ions.

se
mi
pro
Do not com

se
mi
pro
Do not com

co
n

1-INCREASE

7 Pawns

INFECTIOUS SUBSTANCE
IN CASE OF DAMAGE OR
LEAKAGE IMMEDIATELY NOTIFY
LOCAL HEALTH AUTHORITY

Use only in the Bio-Terrorist Challenge.

• Start your turn by looking at as many
Infection cards as the current infection
rate.
• When you do a Direct Flight, reveal the
City card used (but do not discard it).

• You may do up to 5 actions each turn.

ions.

• Once per turn, as an action, you may
move 1 disease cube from the city you are
in onto this Role card.
• When you Discover a Cure, you may
replace 2 of the needed City cards with 3
cubes of the cure color from this card.

recau
t

• Once during your turn, you may
(with permission) take any City card
from a player in the same city with
you. Doing this is not an action.

• When you enter a city with 2 or more
disease cubes of the same color,
remove 1 of them.

ty p

7 Role cards
• Your hand limit is 8 cards.
• Once per turn, as an action, you may
take the City card that matches the city
you are in from the Player Discard Pile
into your hand.

BIO-TERRORIST

TROUBLESHOOTER

afe

GENERALIST

FIELD OPERATIVE

co
n

pr

DRAW THE BOTTOM CARD FROM
THE INFECTION DECK AND PUT
3 CUBES ON THAT CITY. DISCARD
THAT CARD.

SHARE KNOWLEDGE

Play any

Play any

NT

Play any time.

Play any time.

8 Event cards

frst o

rvi
bse

ng

PLAY IMMEDIATELY AFTER A DISCOVER A
CURE ACTION TO REMOVE 1-5 CUBES OF THE
CURED DISEASE. THESE DISEASE CUBES MUST
COME FROM CONNECTED CITIES.

THIS TURN, THE PLAYER MAY SPEND ACTIONS
1 OTHER PAWN (WITH PERMISSION),
AS IF IT WERE HIS OWN.

TO MOVE

PUT THIS CARD IN FRONT OF THIS PLAYER.
DISCARD IT WHEN HIS NEXT TURN BEGINS.

THIS TURN, REMOVE 1 DISEASE CUBE
FROM EACH CITY THE PLAYER

DRIVES/FERRIES TO.

SELECT A PLAYER. THIS PLAYER MAY
ROLE CARD WITH ANY ONE OF THE
UNUSED ROLES.

SWAP HIS

ta
ine
r

with
out

frst o

rvi
bse

pr

ng

ST. PETERSBURG

PARIS

WASHINGTON

MADRID

BAGHDAD

recau
t

LOS ANGELES

ty p
frst o

ng
rvi
bse

KOLKATA
HONG
KONG

CAIRO

TAIPEI

BANGKOK
RIYADH

LAGOS

MUMBAI
KHARTOUM

afe
with
out

SHANGHAI

BOGOT á

op
er
s

is
th

ta
ine
r

DELHI
KARACHI

ALGIERS

REMOVE EACH INDIVIDUAL
MIAMI
STICKER AND
CAREFULLY
PLACE ONE ONTO EACH OF THE
FIVE PETRI DISH COVERS.

ions.

se
mi
pro
Do not com

NEY

MEXICO CITY

co
n

BEIJING

TEHRAN
ISTANBUL

MANILA

SYD

MOSCOW
SEOUL

NEW YORK

TOKYO

ATLANTA

12 Disease cubes

ESSEN

LONDON

MILAN

MONTRÉAL

INFECTIOUS SUBSTANCE
SAN FRANCISCO
IN CASE OF DAMAGE OR
LEAKAGE IMMEDIATELY NOTIFY
REMOVE 2 DISEASE CUBES
LOCAL
HEALTH AUTHORITY
FROM THE BOARD.

SELECT A PLAYER. THIS PLAYER MAY DRAW
ANY 1 CITY CARD FROM THE PLAYER
DISCARD PILE INTO HIS HAND (DISCARDING IF
OVER HIS HAND LIMIT).

TAKE 2 EXTRA ACTIONS THIS TURN.

ions.

co
n

pr

CHICAGO

THE INFECTION RATE IS 1 UNTIL THE

CURRENT PLAYER’S NEXT TURN BEGINS.

recau
t

ions.

recau
t

NT

co Play any time.
nt
ain
er
with
out

ty p

NT

EVE
EVE
CH EVE
TIME
ED RESEAR
TREATMENT
BORROWED
RE-EXAMIN Not an action. REMOTE Not an action.
.
Not an action

afe

NT

EVE
IGNMENT
NEW ASS
an action.
time. Not

is
th

PITAL
MOBILEtime.HOS
.
Not an action

ty p

ENT EVE NT

Reference Card
afe

CINE DEPLOYM

an action.
Cure. Not
Play after

At any research station, discard 5 City cards of the sameYdisease

op
er
s

EVE NT

RAPID VAC

LEAKAGE
DISCOVER
A CURE

CITY color to cure that disease.

FINAL SIZE MARKS

is
th

Play any time.

INFECTIOUS SUBSTANCE
IN CASE OF DAMAGE OR
IMMEDIATELY NOTIFY
LOCAL HEALTH AUTHORIT

CITY
CITY CITY
with

se
mi
pro
Do not com

NT

EVE
ERS
SPECIAL ORD
.
Not an action

Either: give the card that matches the city you are in to another player, or
take that card from another player. The other player must also be in the city
you.

INFECTIOUS SUBSTANCE
IN CASE OF DAMAGE OR
LEAKAGE IMMEDIATELY NOTIFY
LOCAL HEALTH AUTHORITY

SHUFFLE THE CARDS IN THE
INFECTION DISCARD PILE AND
PUT THEM ON TOP OF THE
INFECTION DECK.

se
mi
pro
Do not com

NT

Play any time.

pr

g
vin

e

TREAT DISEASE
Remove 1 disease cube from the city you are in. If this color is cured, remove
all cubes of that color from the city.

3-INTENSIFY

EVE
TRAVEL BAN
COMMERCIAL Not an action.

t

ainA RESEARCH STATION
BUILD

r
Discard therCity
that matches the city you are in tosplace
witcard
b e a research
hout
station there.
frst o

2-INFECT

Epidemic Card

op
er
s

EPIDEMIOLOGIST

op
er
s

CONTAINMENT
SPECIALIST

ARCHIVIST

CHENNAI

pr

HO CHI
MINH CITY

MAN

KINSHASA
JAKARTA
LIMA
S ã O PAULO

Apply the
sticker or
use the
card for the
Mutation or
Bio-Terrorist
challenges

1 Cure Indicator
1 Cure Indicator card

1 Cure marker

NT
ATIO N EVE

MUT
NS!
N THREATE
THE MUTATIO Not an action.
Play at once.

EVE NT
MUTATIO N
EADS

THE MUTATIO

JOHANNESBURG

REMOVE THE CURE
INDICATOR
BUENOS AIRES
STICKER AND CAREFULLY
PLACE IT ONTO YOUR
PANDEMIC BOARD, AS PER THE
ILLUSTRATION.

SANTIAGO

Sticker

Card

EVE NT
MUTATIO N
NSIFIES!

N SPR

THE MUTATIO

.
Not an action
Play at once.

N INTE

.
Not an action
Play at once.

3 Mutation Event cards

Discard the card drawn and this card to the
Infection Discard Pile. If the purple disease is
eradicated, just discard this card. In both cases,
this counts as 1 Infection card draw.

M U TATI O N

2 Mutation cards

PLACE 1 PURPLE DISEASE CUBE ON EACH
CITY WITH EXACTLY 2 PURPLE CUBES
(IGNORE CUBES OF OTHER COLORS).

If the purple disease is not eradicated,
draw a card from the bottom of the
Infection Deck. Place 1 purple disease
cube (only) on this city.

M U TATI O N

IF THE PURPLE DISEASE IS NOT ERADICATED,
DRAW 3 CARDS FROM THE BOTTOM OF THE
INFECTION DECK. PLACE 1 PURPLE DISEASE
CUBE (ONLY) ON EACH OF THESE CITIES.
DISCARD THESE CARDS TO THE INFECTION
DISCARD PILE.

Discard the card drawn and this card to the
Infection Discard Pile. If the purple disease is
eradicated, just discard this card. In both cases,
this counts as 1 Infection card draw.

DRAW A CARD FROM THE BOTTOM OF THE

INFECTION DECK. PLACE 3 PURPLE DISEASE
CUBES ( ONLY ) ON THIS CITY . D ISCARD THAT
CARD TO THE I NFECTION D ISCARD P ILE .

If the purple disease is not eradicated,
draw a card from the bottom of the
Infection Deck. Place 1 purple disease
cube (only) on this city.

IF THE PURPLE DISEASE IS NOT ERADICATED,

8 Virulent Strain Epidemic cards

5 petri dishes with labels

1-INCREASE

1-INCREASE

1-INCREASE

1-INCREASE

2-INFECT

2-INFECT

2-INFECT

2-INFECT

3-INTENSIFY

3-INTENSIFY

3-INTENSIFY

3-INTENSIFY

MOVE THE INFECTION RATE MARKER
FORWARD 1 SPACE.
DRAW THE BOTTOM CARD FROM THE
INFECTION DECK AND PUT 3 CUBES ON
THAT CITY. DISCARD THAT CARD.
SHUFFLE THE CARDS IN THE INFECTION
DISCARD PILE AND PUT THEM ON
TOP OF THE INFECTION DECK.

CONTINUING
EFFECT

CHRONIC EFFECT

During Infections, when a Virulent Strain
city is drawn, place 2 Virulent Strain disease
cubes if the city has no Virulent Strain cubes
(otherwise, place 1 cube normally). This does
not affect Epidemics or Outbreaks.
Date

Bio-Terrorist

Player 1

Player 2

Player 3

MOVE THE INFECTION RATE MARKER
FORWARD 1 SPACE.
DRAW THE BOTTOM CARD FROM THE
INFECTION DECK AND PUT 3 CUBES ON
THAT CITY. DISCARD THAT CARD.
SHUFFLE THE CARDS IN THE INFECTION
DISCARD PILE AND PUT THEM ON
TOP OF THE INFECTION DECK.

CONTINUING
EFFECT

COMPLEX MOLECULAR
STRUCTURE

If the Virulent Strain has not been cured,
you need 1 more Virulent Strain City card to
Discover a Cure for it.
Otherwise, ignore this effect.

MOVE THE INFECTION RATE MARKER
FORWARD 1 SPACE.
DRAW THE BOTTOM CARD FROM THE
INFECTION DECK AND PUT 3 CUBES ON
THAT CITY. DISCARD THAT CARD.
SHUFFLE THE CARDS IN THE INFECTION
DISCARD PILE AND PUT THEM ON
TOP OF THE INFECTION DECK.
GOVERNMENT
INTERFERENCE

CONTINUING
EFFECT

To leave a city with Virulent Strain disease
cubes, a player must first, on that turn, Treat
at least 1 Virulent Strain cube in that city.

MOVE THE INFECTION RATE MARKER
FORWARD 1 SPACE.
DRAW THE BOTTOM CARD FROM THE
INFECTION DECK AND PUT 3 CUBES ON
THAT CITY. DISCARD THAT CARD.
SHUFFLE THE CARDS IN THE INFECTION
DISCARD PILE AND PUT THEM ON TOP OF
THE INFECTION DECK.
HIDDEN POCKET

Before doing this card’s Intensify step, if the Virulent
Strain is eradicated but at least 1 Virulent Strain card
is in the Infection Discard Pile: flip its cure marker back
to its
side; and place 1 cube on each Virulent Strain
city whose card is in this discard pile.
Otherwise, ignore this effect.

Winner

BIO-TERRORIST LOCATION SHEET

Sydney

.
Not an action
Play any time.

Beijing

Tehran

Shanghai
Karachi

Lagos

Bogotá

Hong
Kong

Chennai

Ho Chi
Minh City

Kinshasa
Lima

Santiago

São
Paulo

Tokyo
Osaka

15
16

3

17

4

18

5

19

6

20

7

21

8

22

9

23

10

24

11

25

12

26

13

27

2 actions, plus 1 Drive/Ferry, in any order

• Direct Flight
• Charter Flight
• Draw Card

Skipped Action

1-INCREASE

1-INCREASE

2-INFECT

2-INFECT

2-INFECT

3-INTENSIFY

3-INTENSIFY

3-INTENSIFY

3-INTENSIFY

MOVE THE INFECTION RATE MARKER
FORWARD 1 SPACE.

CONTINUING
EFFECT

RATE EFFECT

During Infections, draw 1 more card than the
infection rate if at least 1 Infection card drawn
was a Virulent Strain card.

MOVE THE INFECTION RATE MARKER
FORWARD 1 SPACE.
DRAW THE BOTTOM CARD FROM THE
INFECTION DECK AND PUT 3 CUBES ON
THAT CITY. DISCARD THAT CARD.
SHUFFLE THE CARDS IN THE INFECTION
DISCARD PILE AND PUT THEM ON
TOP OF THE INFECTION DECK.

CONTINUING
EFFECT

SLIPPERY SLOPE

Move the outbreaks marker forward
2 spaces (not 1) when an outbreak of the
Virulent Strain occurs.

MOVE THE INFECTION RATE MARKER
FORWARD 1 SPACE.
DRAW THE BOTTOM CARD FROM THE
INFECTION DECK AND PUT 3 CUBES ON
THAT CITY. DISCARD THAT CARD.
SHUFFLE THE CARDS IN THE INFECTION
DISCARD PILE AND PUT THEM ON TOP OF
THE INFECTION DECK.

MOVE THE INFECTION RATE MARKER
FORWARD 1 SPACE.
DRAW THE BOTTOM CARD FROM THE
INFECTION DECK AND PUT 3 CUBES ON
THAT CITY. DISCARD THAT CARD.
SHUFFLE THE CARDS IN THE INFECTION
DISCARD PILE AND PUT THEM ON TOP OF
THE INFECTION DECK.

UNACCEPTABLE LOSS

UNCOUNTED POPULATIONS

Before doing this card’s Intensify step,
remove 4 Virulent Strain disease cubes from the
supply to the box. If fewer than 4 of these cubes
are in the supply, instead remove them all.

Before doing this card’s Intensify step,
place 1 Virulent Strain disease cube on each
city with exactly 1 of these cubes
(ignore cubes of other colors).

14

2

• Drive/Ferry

1-INCREASE

2-INFECT

SHUFFLE THE CARDS IN THE INFECTION
DISCARD PILE AND PUT THEM ON
TOP OF THE INFECTION DECK.

Sydney

1

Actions

1-INCREASE

DRAW THE BOTTOM CARD FROM THE
INFECTION DECK AND PUT 3 CUBES ON
THAT CITY. DISCARD THAT CARD.

Manila

Johannesburg

Buenos
Aires

STARTING CITY:

EVE NT

Moscow

Istanbul

San Francisco

Milan

Madrid

Miami

Mexico
City

Los Angeles

Manila

4 blank cards

1 Bio-Terrorist
location pad

Los
Angeles

St. Petersburg

Essen

London
San
Francisco

Sample Notation

Hidden Actions

Atlanta
Atlanta
Atlanta
D

• Infect Locally
Announce airport
Announce airport

Sample Notation

I
R Atlanta

• Infect Remotely
• Sabotage

Discard city
Discard matching color

If Captured
• Draw Card
• Escape

Each only once per turn

E

C
D
Atlanta

Lose cards
Announce airport

On the Brink cards have this
icon in their lower right corners,
so you can easily separate them.

1

1.Do 4 action
2.Draw 2 car

•Resolve an

•Discard to

3.Infect cities

To see a Pandemic On the Brink teaching video, go to:
www.zmangames.com/on-the-brink-online-rules.htm

OVERVIEW

This expansion adds a 5th player, 6 roles, 8 events, and 3 challenges to
Pandemic.

• Virulent Strain challenge: makes one disease particularly nasty in
unpredictable ways.

To get started, play the base game with the new roles and events. You
may also add a challenge to vary the game some more. We suggest you
try the three challenges in order:

• Mutation challenge: adds a 5th (purple) disease that behaves differently
from the original four.
• Bio-Terrorist challenge: pits one player against the others.

NEW ROLES, EVENTS, AND RULES

Stack

Fine Points
NT

EVE
TIME
BORROWED
.
Not an action
Play any time.

TAKE 2 EXTRA ACTIONS THIS TURN.

NT

EVE
PITAL
MOBILEtime.HOS
.
Not an action
Play any

THIS TURN, REMOVE 1 DISEASE CUBE
FROM EACH CITY THE PLAYER

DRIVES/FERRIES TO.

NT

EVE
IGNMENT
NEW ASS
an action.
time. Not
Play any

SELECT A PLAYER. THIS PLAYER MAY
ROLE CARD WITH ANY ONE OF THE
UNUSED ROLES.

SWAP HIS

EVE NT

CINE
RAPID VAC

DEPLOYMENT

an action.
Cure. Not
Play after

PLAY IMMEDIATELY AFTER A DISCOVER A
CURE ACTION TO REMOVE 1-5 CUBES OF THE
CURED DISEASE. THESE DISEASE CUBES MUST
COME FROM CONNECTED CITIES.

NT

EVE
ERS
SPECIAL ORD
.
Not an action
Play any time.

THIS TURN, THE PLAYER MAY SPEND ACTIONS
1 OTHER PAWN (WITH PERMISSION),
AS IF IT WERE HIS OWN.

TO MOVE

2

Borrowed Time
The player drawing this card may not immediately play
it to continue taking actions (as that player is now in the
Draw Cards step of his turn).

3-INTENSIFY
SHUFFLE THE CARDS IN THE
INFECTION DISCARD PILE AND
PUT THEM ON TOP OF THE
INFECTION DECK.

1-INCREASE
MOVE THE INFECTION RATE
MARKER FORWARD 1 SPACE.

2-INFECT
DRAW THE BOTTOM CARD FROM
THE INFECTION DECK AND PUT
3 CUBES ON THAT CITY. DISCARD
THAT CARD.

3-INTENSIFY
SHUFFLE THE CARDS IN THE
INFECTION DISCARD PILE AND
PUT THEM ON TOP OF THE
INFECTION DECK.

1-INCREASE
MOVE THE INFECTION RATE
MARKER FORWARD 1 SPACE.

2-INFECT
DRAW THE BOTTOM CARD FROM
THE INFECTION DECK AND PUT
3 CUBES ON THAT CITY. DISCARD
THAT CARD.

3-INTENSIFY
SHUFFLE THE CARDS IN THE
INFECTION DISCARD PILE AND
PUT THEM ON TOP OF THE
INFECTION DECK.

1-INCREASE
MOVE THE INFECTION RATE
MARKER FORWARD 1 SPACE.

2-INFECT
DRAW THE BOTTOM CARD FROM
THE INFECTION DECK AND PUT
3 CUBES ON THAT CITY. DISCARD
THAT CARD.

3-INTENSIFY
SHUFFLE THE CARDS IN THE
INFECTION DISCARD PILE AND
PUT THEM ON TOP OF THE
INFECTION DECK.

1-INCREASE
MOVE THE INFECTION RATE
MARKER FORWARD 1 SPACE.

2-INFECT
DRAW THE BOTTOM CARD FROM
THE INFECTION DECK AND PUT
3 CUBES ON THAT CITY. DISCARD
THAT CARD.

3-INTENSIFY
SHUFFLE THE CARDS IN THE
INFECTION DISCARD PILE AND
PUT THEM ON TOP OF THE
INFECTION DECK.

1-INCREASE
MOVE THE INFECTION RATE
MARKER FORWARD 1 SPACE.

2-INFECT
DRAW THE BOTTOM CARD FROM
THE INFECTION DECK AND PUT
3 CUBES ON THAT CITY. DISCARD
THAT CARD.

CANADA

DRAW THE BOTTOM CARD FROM
THE INFECTION DECK AND PUT
3 CUBES ON THAT CITY. DISCARD
THAT CARD.

MONTREAL

SHUFFLE THE CARDS IN THE
INFECTION DISCARD PILE AND
PUT THEM ON TOP OF THE
INFECTION DECK.

MOVE THE INFECTION RATE
MARKER FORWARD 1 SPACE.

2-INFECT

CANADA

3-INTENSIFY

1-INCREASE

MONTREAL

Play the new Events normally.

CANADA

DRAW THE BOTTOM CARD FROM
THE INFECTION DECK AND PUT
3 CUBES ON THAT CITY. DISCARD
THAT CARD.

CANADA

MONTREAL

MOVE THE INFECTION RATE
MARKER FORWARD 1 SPACE.

2-INFECT

MONTREAL

1-INCREASE

CANADA

This is a rules change from the base game.

Feeling invincible? Try the Legendary difficulty level. Use the Epidemic card
in this expansion to play with 7 Epidemic cards.

MONTREAL

Add the 8 new Event cards to the 5 base game Event cards and shuffle
them face down. Add 2 Event cards per player to the Player cards,
before shuffling and dealing Player cards to each player. Put unused
Event cards back in the box without looking at them.

Legendary Game

CANADA

New Events

Pandemic can be played with 5 players. During setup, deal a Role card to the
5th player and 2 Player cards (as with 4 players) to each player.

MONTREAL

Use the Bio-Terrorist Role card only when playing
the Bio-Terrorist challenge.

5-Player Game

CANADA

Add the 6 new Role cards to the base game Role cards before shuffling
and dealing 1 Role card to each player. See page 8 for more details.

MONTREAL

New Roles

3-INTENSIFY
SHUFFLE THE CARDS IN THE
INFECTION DISCARD PILE AND
PUT THEM ON TOP OF THE
INFECTION DECK.

Shuffle
Set up the game normally (separating the Player cards into 7 piles before
shuffling an Epidemic card into each pile).
When you draw the 7 th Epidemic, the infection rate remains at 4
(the track maximum).

Mobile Hospital
The Containment Specialist first removes 1 cube of each
color with 2 or more cubes present and then removes 1
more cube (for each city entered).

Warning: Not for the faint of heart...

New Assignment
If the current player was selected and he swapped either
from or to the Generalist role, then he may do up to 5
actions this turn.

Each challenge adds some difficulty, so you may wish to try each new
challenge with 1 fewer Epidemic card than you would normally use when
playing the base game.

Rapid Vaccine Deployment
This can be played only immediately after a Discover a
Cure action. Each affected city must be connected to at
least 1 other city affected by this event (unless this event
affects just 1 city). At least 1 cube must be removed from
each of these cities.
Special Orders
As when moving other pawns with the Dispatcher, the
current player must discard (or reveal) any cards used
to move that pawn by Direct or Charter flights. Powers
that are part of movement (such as the Medic’s power
to remove cured disease cubes or the Containment
Specialist’s power) do occur.

Adding Challenges

Experienced players may combine the Virulent Strain with either the Mutation
or Bio-Terrorist challenges.

VIRULENT STRAIN CHALLENGE
In the Virulent Strain challenge, a disease has gone out of control in nasty,
unpredictable ways.

Fine Points

Setup

1-INCREASE

MOVE THE INFECTION RATE MARKER
FORWARD 1 SPACE.

2-INFECT

DRAW THE BOTTOM CARD FROM THE
INFECTION DECK AND PUT 3 CUBES ON
THAT CITY. DISCARD THAT CARD.

3-INTENSIFY

1-INCREASE

MOVE THE INFECTION
RATE
MARKER FORWARD
1 SPACE.

SHUFFLE THE CARDS IN THE INFECTION
DISCARD PILE AND PUT THEM ON TOP OF
THE INFECTION DECK.

MONTREAL

2-INFECT

DRAW THE BOTTOM CARD
THE INFECTIO
N DECK AND FROM
PUT
3 CUBES ON THAT
CITY. DISCARD
THAT CARD.

CANADA

Put the normal Epidemic cards in the box — you will not
need them. Prepare the Player Deck (step 5) using Virulent
Strain Epidemic cards instead. Select the Virulent Strain
Epidemic cards to use by shuffling them face down before
taking the needed number (4-7, based on your difficulty
level). Put the unused cards away without looking at them.

3-INTENSIFY

SHUFFLE
CARDS IN THE
INFECTIO THE
DISCARD PILE
PUT THEMN ON
TOP OF THEAND
INFECTION DECK.

HIDDEN POCKET
Before doing this card’s Intensify step, if the Virulent
Strain is eradicated but at least 1 Virulent Strain card
is in the Infection Discard Pile: flip its cure marker back
to its
side; and place 1 cube on each Virulent Strain
city whose card is in this discard pile.
Otherwise, ignore this effect.

Prepare the Player Deck
Stack
1-INCREASE

MOVE THE INFECTION RATE MARKER
FORWARD 1 SPACE.

2-INFECT

DRAW THE BOTTOM CARD FROM THE
INFECTION DECK AND PUT 3 CUBES ON
THAT CITY. DISCARD THAT CARD.

3-INTENSIFY

SHUFFLE THE CARDS IN THE INFECTION
DISCARD PILE AND PUT THEM ON
TOP OF THE INFECTION DECK.

Shuffle

CONTINUING
EFFECT

1-INCREASE

1-INCREASE

1-INCREASE

1-INCREASE

2-INFECT

2-INFECT

2-INFECT

2-INFECT

3-INTENSIFY

3-INTENSIFY

3-INTENSIFY

3-INTENSIFY

MOVE THE INFECTION RATE MARKER
FORWARD 1 SPACE.
DRAW THE BOTTOM CARD FROM THE
INFECTION DECK AND PUT 3 CUBES ON
THAT CITY. DISCARD THAT CARD.
SHUFFLE THE CARDS IN THE INFECTION
DISCARD PILE AND PUT THEM ON
TOP OF THE INFECTION DECK.

CONTINUING
EFFECT

CHRONIC EFFECT

During Infections, when a Virulent Strain
city is drawn, place 2 Virulent Strain disease
cubes if the city has no Virulent Strain cubes
(otherwise, place 1 cube normally). This does
not affect Epidemics or Outbreaks.

MOVE THE INFECTION RATE MARKER
FORWARD 1 SPACE.
DRAW THE BOTTOM CARD FROM THE
INFECTION DECK AND PUT 3 CUBES ON
THAT CITY. DISCARD THAT CARD.
SHUFFLE THE CARDS IN THE INFECTION
DISCARD PILE AND PUT THEM ON
TOP OF THE INFECTION DECK.

CONTINUING
EFFECT

COMPLEX MOLECULAR
STRUCTURE

If the Virulent Strain has not been cured,
you need 1 more Virulent Strain City card to
Discover a Cure for it.
Otherwise, ignore this effect.

MOVE THE INFECTION RATE MARKER
FORWARD 1 SPACE.
DRAW THE BOTTOM CARD FROM THE
INFECTION DECK AND PUT 3 CUBES ON
THAT CITY. DISCARD THAT CARD.
SHUFFLE THE CARDS IN THE INFECTION
DISCARD PILE AND PUT THEM ON
TOP OF THE INFECTION DECK.

CONTINUING
EFFECT

GOVERNMENT
INTERFERENCE

To leave a city with Virulent Strain disease
cubes, a player must first, on that turn, Treat
at least 1 Virulent Strain cube in that city.

MOVE THE INFECTION RATE MARKER
FORWARD 1 SPACE.

GOVERNMENT
INTERFERENCE

To leave a city with Virulent Strain disease
cubes, a player must first, on that turn, Treat
at least 1 Virulent Strain cube in that city.

DRAW THE BOTTOM CARD FROM THE
INFECTION DECK AND PUT 3 CUBES ON
THAT CITY. DISCARD THAT CARD.
SHUFFLE THE CARDS IN THE INFECTION
DISCARD PILE AND PUT THEM ON TOP OF
THE INFECTION DECK.
HIDDEN POCKET

Before doing this card’s Intensify step, if the Virulent
Strain is eradicated but at least 1 Virulent Strain card
is in the Infection Discard Pile: flip its cure marker back
to its
side; and place 1 cube on each Virulent Strain
city whose card is in this discard pile.
Otherwise, ignore this effect.

Use 4 Virulent Strain Epidemic cards for your first game.
Use 6 after mastering the Standard game.
Divide the remaining player cards into face down piles, as equal in size as
you can, so that the number of piles matches the number of Virulent Strain
Epidemic cards you are using. Shuffle 1 Virulent Strain Epidemic card into
each pile, face down. Stack these piles to form the Player Deck, placing
smaller piles on the bottom.

Determining the Virulent Strain

When a player draws the first Virulent Strain Epidemic card, determine which
disease will be the Virulent Strain for the rest of the game. After performing
this card’s Infect step, the disease with the most cubes on the board is the
Virulent Strain. Finish doing this Epidemic and its Virulent Strain effect (see
below). Put this card next to the Virulent Strain’s cube supply as a reminder.

1-INCREASE

MOVE THE INFECTION RATE MARKER
FORWARD 1 SPACE.

2-INFECT

DRAW THE BOTTOM CARD FROM THE
INFECTION DECK AND PUT 3 CUBES ON
THAT CITY. DISCARD THAT CARD.

3-INTENSIFY

SHUFFLE THE CARDS IN THE INFECTION
DISCARD PILE AND PUT THEM ON
TOP OF THE INFECTION DECK.

CONTINUING
EFFECT

RATE EFFECT

During Infections, draw 1 more card than the
infection rate if at least 1 Infection card drawn
was a Virulent Strain card.

Complex Molecular Structure
A player would need to turn in 6 city
cards of the Virulent Strain color to cure
the Virulent Strain, except the Scientist,
who would turn in 5 cards, or the Field
Operative, who could turn in 4 cards and 3
Virulent Strain samples.

Government Interference
Removing (but not Treating) a Virulent
Strain disease cube—with the Containment
Specialist’s power, the Field Operative’s
sample power, or the Events Remote
Treatment or Rapid Vaccine Development—
does not satisfy this effect’s requirement.
The Event Mobile Hospital does satisfy it.
Other players’ pawns affected by this effect
cannot be moved by the Dispatcher or the
Events Airlift or Special Order, unless the
current player first Treats a cube in the
same city that the pawn being moved is in.
Rate Effect
If the Troubleshooter sees a Virulent
Strain city card when looking at Infection
cards while Rate Effect is in effect, the
Troubleshooter does not look at an
additional card. When combining this
challenge with the Mutation challenge, if
the card drawn to resolve a Mutation card
is a Virulent Strain city, that card does not
count towards Rate Effect.

If several diseases are tied for most cubes on the board, randomly
choose the Virulent Strain from among the tied diseases.
If you are also playing with the Mutation or Bio-Terrorist challenge,
the purple disease cannot be the Virulent Strain. Ignore it when
determining the Virulent Strain.

Virulent Strain Epidemic Effects

Besides its Epidemic effects, each Virulent Strain Epidemic card has an effect
which applies only to the Virulent Strain disease. Read the card aloud and
follow its instructions. Some cards have a continuing effect; these affect
play after the Epidemic is done. Keep these cards face up as reminders.
Others have an immediate effect, taking place before the Intensify step of the
Epidemic. Flip these cards face down after their effect and Epidemic is done.

Winning and Losing

This challenge is won or lost normally, as in the base game.
Good luck!

3

MUTATION CHALLENGE
The Mutation challenge adds a 5th purple disease to the game that
appears in unpredictable ways. Players must either cure all 5 diseases or
cure the 4 other diseases and have no purple disease cubes on the board.

EV EN T
M UTAT IO N REATENS!
ION TH

THE MUTAT

action.
e. Not an
Play at onc

Setup

Put the 12 purple disease cubes near the other cubes as a supply. Put the
purple Discovered Cure Indicator and cure marker on the board. Put the 2
Mutation cards in the Infection Discard Pile (do not shuffle them into the
Infection Deck).

Mutation Event Cards

When a Mutation Event card is drawn, follow its
instructions and discard it. Do not draw a Player
card to replace it.

IF THE PURPLE DISEASE IS NOT ERADICATED,
DRAW A CARD FROM THE BOTTOM OF THE

INFECTION DECK. PLACE 3 PURPLE DISEASE
CUBES ( ONLY ) ON THIS CITY . D ISCARD THAT
CARD TO THE I NFECTION D ISCARD P ILE .

2 Mutation Event cards place purple cubes on cities of cards drawn
from the bottom of the Infection Draw Pile. Do not place cubes of
those cards’ colors on those cities.

MU TA TIO N
MU
TA

T IO

is not eradicated,
If the purple disease If the purof the
bottom ple dis
draw a card from thedraw a disease
ease is
car
1 purple
Infection Deck. PlaceInfection d from the not eradicate
bottom
Deck.
city.
d,
Place
cube (only) on this cube (on
of the
1
ly) the
this city purple diseas
this card toon
and
Discard the card drawnDiscard the
.
e
is

N

If a player draws both a Mutation Event card and an Epidemic card, do the
Mutation Event first.
If a player draws 2 Mutation Event cards,
the player decides the order to do them.

disease
If the purplecard
drawn
Infection Discard Pile.Infection DiscIn both
and this
card. ard cases,
eradthis
card to
Pile.
icated,
eradicated, just discard
the
just disc If the purple
card draw.
this cou
disease
ard this
this counts as 1 Infection
nts as
is
card
1 Infe
ction card . In both
cases,
draw.

After dealing cards to players, but before preparing the Player Deck (step
5), shuffle the 3 Mutation Event cards with the remaining Player cards.
EN T
S! ION EVE NT
IO N EV MU
ENTAT
S ATIO N
M UTAT ION THREAT
MUT
N SPREAD
EVEN T
.
action MUTATIO
UTAT

THE M

Play

e.
at onc

Not an

THE

THE MUTATION

.
Not an action
Play at once.

INTENSIFIES!

Play at once. Not
an action.

ATED ,
NOT ERADIC
DISEASE IS NOT ERADICATED,
DISEAS E IS IF THE PURPLE
THE
BOTTOM OF
FROM THE DRAW 3 CARDSE FROM THE BOTTOM OF THE
DISEAS
PLACE DISEASE
DRAW A CARD
INFECTION
DECK. PLACE 1 PURPLE
1 PURPLE
. PLACE 3 PURPLE
THAT
DISE ASE
ISCARD
INFECTION DECK THIS CITY. DCUBE
CITY CITIES
(ONLY). ON EACH OF THESE
WITH .
CUBE
) ON
EXAC TLY
PILE
CUBES ( ONLY
(IGNO
2 PURPLE ON EACH
ISCARD THESE CARDS TO THE
INFECTION
RE CUBE
INFECTION DDISCARD
CUBE S
S OF OTHE
CARD TO THE
DISCARD PILE.
R COLO
RS ).

IF THE PURPLE

The Mutation (Purple) Disease

The purple disease is like the other 4 diseases, except as
noted below. Purple disease cubes enter play in three ways.

Mutation Cards
MUTATIO N
If the purple disease is not eradicated,
draw a card from the bottom of the
Infection Deck. Place 1 purple disease
cube (only) on this city.
Discard the card drawn and this card to the
Infection Discard Pile. If the purple disease is
eradicated, just discard this card. In both cases,
this counts as 1 Infection card draw.

During Infections, if a Mutation card is
drawn (and the purple disease is not
eradicated), draw an Infection card from
the bottom of the Infection Deck and
place 1 purple cube on that city. Do not
place a cube of the card’s color on the
city. Discard both cards to the Infection
Discard Pile.

This counts as 1 Infection card draw for the turn.
The Event Resilient Population cannot be used to remove a
Mutation card from the Infection Discard Pile.

4

Infections

During Infections, if an Infection card is drawn for a city with at least 1 purple
cube on it, place both 1 purple cube (if purple is not eradicated) and 1 cube
of this card’s color (if that disease is not eradicated) on the city, resolving
any outbreak(s) normally.
An Infection draw is the only time when cubes of both colors are
placed. When drawing cards from the bottom of the Infection Deck,
either just cubes of that card’s color (for Epidemics) or just purple
cubes (for Mutation cards and Mutation Events) are placed.

Curing the Purple Disease

When Discovering a Cure for the purple disease, discard 5 City
cards in any mix of colors, with at least 1 of them a city that has
1 or more purple cubes on it.
When a Scientist or Field Operative turns in fewer City cards,
at least 1 of them must be a city with 1 or more purple cubes on it.

If the purple disease is eradicated and a Mutation card is drawn during
Infections, just discard it. It still counts as 1 Infection card draw for the turn.

Winning or Losing

The players win immediately if they either cure all 5 diseases or cure the
4 other diseases and have no purple disease cubes on the board.
Like any other disease, if you cannot place the number of purple
cubes actually needed on the board, your team loses. There are only
12 (not 24) purple cubes in the supply!

BIO-TERRORIST CHALLENGE
This challenge pits one player, the Bio-Terrorist, against the others, seeking
to create panic throughout the world with a 5th disease.
This challenge works with 3 or 4 players. 5 players
(1 Bio-Terrorist and 4 other players) is not recommended.

The Bio-Terrorist wins if the other players lose and there is at least 1 purple
disease cube on the board. To win, the other players must either cure all
5 diseases or cure the 4 standard diseases and have no purple disease cubes
on the board.
The Bio-Terrorist challenge may be combined with
the Virulent Strain challenge, but not the Mutation challenge.

Play

Non-Terrorist players take their turns normally, except they now have a
possible Capture action (see below).
The Bio-Terrorist takes a turn after each player’s turn (after that player
Infects Cities). The Bio-Terrorist can do up to 2 actions, plus 1 Drive/
Ferry action (in any order). The Bio-Terrorist does not automatically
Draw Cards nor Infect Cities; he must use actions to do so. The
Bio-Terrorist uses Infection cards (not Player cards) during play,
discarding them to the Infection Discard Pile.

Bio-Terrorist Secrecy

The Bio-Terrorist moves secretly about the board, keeping track of his
actions on his Location sheet.

Setup

Whenever the Bio-Terrorist is in the same city as other player(s),
the Bio-Terrorist is spotted and puts his pawn on the board. If he (or
another player) then moves so that the Bio-Terrorist is not in the same
city as another player, the Bio-Terrorist removes his pawn from the
board.

Select the Bio-Terrorist player. Give him the Bio-Terrorist Role card, the
black pawn, a folded Location sheet, and a pencil. The black pawn begins
off the board. After infecting 9 cities (step 3), deal 2 Infection cards to the
Bio-Terrrorist.
Select the Bio-Terrorist either randomly, by including the Bio-Terrorist
Role card among the Roles dealt out, or by choosing a volunteer.

Put the 12 purple disease cubes near the other cubes as a supply. Put the
purple Discovered Cure Indicator and cure marker on the board. Use 2 Event
cards per player in the game, including the Bio-Terrorist (for this purpose
only). Deal Player cards to the non-Terrorist players normally.

Determine the first player among the non-Terrorist players. The Bio-Terrorist
then secretly notes on his Location sheet the city he will start in. The first
player begins play.

If the Bio-Terrorist moves by a Direct or Charter Flight (see below), he
discards the card to the Infection Discard Pile and announces that his
pawn was “sighted” at that airport. He does not reveal if he used the
card for a Direct or Charter flight nor on which of his actions this flight
took place.
While players often plan out their entire turn before taking any
actions, turns are done one action at a time. A player who moves
and spots the Bio-Terrorist may, if he has any actions left,
then choose to capture the Bio-Terrorist.
The Bio-Terrorist performs his actions one at a time, possibly
placing purple disease cubes, discarding cards, or announcing
airport sightings. He does not announce which action he is doing,
CITYbut players may be able to deduce information based on
the order in which things happen.

Capturing the Bio-Terrorist

If the Bio-Terrorist pawn is on the board, a player in the same city as
the Bio-Terrorist may, for an action, capture him.

San
Francisco

1

Washington

Atlanta

Algiers

Riyadh

Manila

Manila

Ho Chi
Minh City

Sydney

Jakarta

Sydney

rg

Johannesbu

São
Paulo

Santiago

Chennai

Kinshasa

Lima

Osaka

Hong
Kong

Mumbai

Khartoum

Lagos
Bogotá

Tokyo

Shanghai

Karachi

Cairo

Miami

Mexico
City

Tehran

Istanbul
Madrid

Seoul

Beijing

Milan

Buenos
Aires

San Francisco

St. Petersburg
Essen
London

New York

Chicago

Los
Angeles

Capture: Put the Bio-Terrorist pawn on your role
card. He discards all cards in hand to the Infection
Discard Pile (without effect).

ON SHEET

RIST LOCATI

BIO-TERRO

Los Angeles

Date

Winner

Player 3

Player 2

Player 1

st
Bio-Terrori

1. Map

2

2. Fold Line

14
15

CITY:

STARTING

Fold the map section down over the action log section to
hide your current location from the other players.

16

1

17

2

18

3
4

19

3

5
6
7

20

3. Action Log

21
22

Record your starting city location and actions for
each turn here.

23

8

24

9

25

10

26

11

27

12
13

rry, in any

Drive/Fe
ns, plus 1

2 actio

Actions

y
• Drive/Ferr
t
• Direct Fligh
• Charter Fligh
• Draw Card

t

on
Skipped Acti

ons

Hidden Acti

order

tion

Sample Nota

Atlanta
Atlanta
Atlanta
D

rt
Announce airpo
rt
Announce airpo

lly
• Infect Loca
tely
• Infect Remo

tion

Sample Nota

I
R Atlanta

• Sabotage

If Captured

• Draw Card
• Escape

E

C
D
Atlanta

Each only once

4

per turn

Discard city
hing color
Discard matc
Lose cards
rt

Announce airpo

4. Suggested Action Notation

5

BIO-TERRORIST ACTIONS
On his turn, the Bio-Terrorist may take up to 2 actions, plus 1 Drive/Ferry
action. This optional Drive/Ferry action may be done before, after, or
between his other 2 actions.
As the Bio-Terrorist, record your actions on your Location sheet
to track your current location. Suggested notation is provided.

ACTIONS
Each of these actions may be done twice per turn (up to 3 times for Drive/
Ferry when combined with the extra one).

Draw Card

While Captured: the Bio-Terrorist can do only Draw Card or Escape actions.

Escape

Discard an Infection Card to move to its city. Announce an
airport sighting there. Take back the Bio-Terrorist pawn

ROLE

Since the Bio-Terrorist loses all cards in hand when captured,
his 1st action after being captured will be Draw Card. He can use
this card to Escape or draw another card (skipping his Drive/Ferry
action). After the Bio-Terrorist does an Escape action, he completes
his turn normally (taking a 2nd action if he escaped on his 1st action,
plus his optional Drive/Ferry action).

Draw 1 card from the Infection Deck into hand.

The Bio-Terrorist (Purple) Disease
The purple disease is like the other 4 diseases, except
as noted below. Purple disease cubes enter play by BioTerrorist actions and infections.

The Bio-Terrorist’s hand limit is 7 cards; if he has more than 7,
he must discard the 8th card to the Infection Discard Pile
(without effect).

Infections

Drive/Ferry

During Infections, if an Infection card is drawn for a city with at least 1 purple
cube on it, place both 1 purple cube (if purple is not eradicated) and 1 cube
of the card’s color (if that disease is not eradicated) on the city, resolving any
outbreak(s) normally for the card’s color and as below for purple.

Move to a connected city.

Direct Flight

Discard an Infection card to move to its city. Announce
an airport sighting there.

CITY

An Infection draw is the only time when cubes of both colors are
placed. When the Bio-Terrorist Infects Remotely, only 1 purple cube
is placed. When drawing a card for an Epidemic, only 3 cubes of that
color are placed.

Charter Flight

Discard the Infection card that matches the city you are in
to move to any city. Announce an airport sighting in the
city you left.

CITY

Hidden Actions: each of these actions may be done only once per turn,
if the Bio-Terrorist is not spotted (or captured).
CITY

Infect Locally
CITY Place 1 purple cube on your current city.
CITY

CITY

Infect Remotely

Discard an Infection card to place 1 purple cube (only)
on that city.
The Bio-Terrorist may Infect Remotely the city he is in.

Purple “Flare-Out” Outbreaks

Outbreaks of the Bio-Terrorist’s purple disease (only) are so intense that they
“flare out”, leaving the cities they outbreak from with just 1 purple cube.
This applies to the Bio-Terrorist challenge only,
not the Mutation challenge.

To do a purple outbreak, remove 2 purple cubes from that city (returning
them to the supply) and then place 1 purple cube on each city connected to
it (moving the outbreaks marker forward 1 space).
If a purple disease outbreak results in “chain reaction” outbreaks,
do not add purple cubes to cities that have already had an outbreak
as part of resolving the current action or Infection card.

Sabotage

Remove a Research Station in your city, discarding an
Infection card whose color matches this city. Return the
Research Station to the supply.

Curing the Purple Disease

When Discovering a Cure for the purple disease, discard 5 City
cards in any mix of colors, with at least 1 of them a city that has
1 or more purple cubes on it.
When a Scientist or Field Operative turns in fewer City cards,
at least 1 of them must be a city with 1 or more purple cubes on it.

6

CITY

Buenos

Aires
BIO-TERRORIST
LOCATION SHEET

Santiago

STARTING CITY:
Tokyo

1

Manila

Winning and Losing

ESSEN

LONDON
The Bio-Terrorist wins if the players lose and there is at least 1 purple
cube on the board. The Bio-Terrorist loses (and is out of the game) if the
MONTRÉAL
players ever eradicate the CHICAGO
purple disease.
NEW YORK
PARIS

MA NIL A

ALGIERS

Everyone loses if the players lose and there are no purple cubes on the
board.
MIAMI

Etiquette

LAGOS

FINAL SIZE MARKS

Player 1

Riyadh

22

Player 2

Player 3

TOKYO

SAN
FRANCISCO

FINAL SIZE MARKS

SAN
FRA NCIS CO

2 actions, plus 1 Drive/Ferry, in anyCHENNAI
order

Istanbul

Madrid

Francisco

Mumbai

Khartoum

21

I

BEIJING

Karachi

23
SHANGHAI
BAGHDAD
DELHI
BIO-TERRORIST LOCATION SHEET
10
24
KARACHI
KOLKATA
STARTING CITY:
14
HONG
R
KONG
11
25
OSAKA
CAIRO
AIRO
1
TAIPEI 15
BANGKOK
The12next playerRIYADH
takes her turn, neither entering Shanghai nor Essen 26 St. Petersburg
2
16
MUMBAI
removing
any purple cubes.
She draws an EpidemicLondon
card that putsMilan
13
27
Moscow
KHARTOUM
Chicagoand Montréal
3 red3 cubes in Beijing
the Infection
discards back on theParis
deck. 17
New York
San

Tokyo

BOGOT á
The Bio-Terrorist may listen to the other players
as they discuss their plans
and cards, but should not interrupt them on their turns. The non-Terrorist
players may not hold private discussions nor pass notes to each other.

TEHRAN

Bio-Terrorist

9

MEXICO CITY

Baghdad

Johannesburg

Shanghai
SEOUL

Date
ISTANBUL

TOKYO

I

Buenos
Aires

Santiago

MOSCOW

MILAN

8

CAIRO

The Bio-Terrorist must be careful not to allow the purple disease
MADRID
WASHINGTON
to be cured and then immediately
eradicated.

LOS ANGELES

R Cairo

7

Tehran

Cairo

Mexico
3
17
City
In the mid-game, there
is 1 purple cube each in Cairo and Seoul.
Lagos
The4 Bio-Terrorist is hidden in Seoul and holds 3 Infection cards:
18
Bogotá
Cairo, Istanbul, and Shanghai.
Kinshasa
5
19
On his turn, the Bio-Terrorist Infects Remotely in Cairo (discarding
Lima
São
hisST.6Cairo
card), Infects Locally in Seoul, and
PETERSBURG
Paulo Drives to Shanghai. 20

EGYPT

SAN FRANCISCO

NEY

16

Algiers

Sydney

Like any other disease, if you cannot place the number of purple
cubes actually needed on the board, the players lose (and the
Bio-Terrorist wins). There are only 12 (not 24) purple cubes in
the supply!

SYD

Washington

Atlanta

Moscow

15Istanbul

Madrid

Los
Angeles

St. Petersburg

14

Milan

Paris

New York

Sample Bio-Terrorist Turns
Miami

The non-Terrorist players win if they either cure all 5 diseases or cure
the 4 standard diseases and have no purple disease cubes on the board.

ATLANTA

Montréal

Chicago

San
Francisco

2

FINAL SIZE MARKS

Essen

London

Tehran

Manila

MANILA
HO CHIcube and
During
Cairo is
drawn. Both 1 black
AtlantaSampleWashington
4 the Infections step,
18 Actions
Baghdad
MINH CITY
Actions
Notation
Hidden
Algiers
KINSHASA 1 purple cube are placed in Cairo.
Karachi
Cairo
Los

Infect
Locally
• Drive/Ferry
Atlanta
MONTRÉAL
Miami
5 Angeles
19 CHICAGO
Mexico
JAKARTA

Infect
Remotely

Direct
Flight
Announce
airport
The Bio-Terrorist may not reveal Infection Cards in hand until playing
Riyadh
Atlanta
City discards his
The Bio-Terrorist then
Shanghai card for a SAN
Charter
FRANCISCO
LIMA
Mumbai
them, but must disclose, when asked, how many cards are
his hand. The
• Khartoum
Sabotage
Announce airport
• Charter
Flight announcing a Shanghai
Atlanta airport sighting;
S ã O in
PAULO
Flight
Infects
6 to Cairo,
20
Lagos
Bio-Terrorist is on the “honor system” for recording his own location and
• Draw in
Card
Locally
Cairo, producingBogotá
an outbreak
there; and then Drives to If Captured
D
JOHANNESBURG
7
Kinshasa21
reporting whenever he is spotted.
• DrawATLANTA
Card
Istanbul.
Skipped Action
ST. PETERSBURG

Sydney

TOKYO

MA NIL A

LO S S
LE
AN GE

BUENOS AIRES

SANTIAGO

As the Bio-Terrorist can do nothing on the other players’ turns and they
can do nothing on Bio-TerroristCHICAGO
turns, we MONTRÉAL
recommend that everyone
NEW YORK
keeps this in SAN
mind
and
plays
briskly
(although
tricky situations
FRANCISCO
needing discussion can arise — this is not intended to prevent these
MADRID
discussions).
WASHINGTON

8

LONDON

9
PARIS

S

EY
YDN

PEOPLE’S REPUBLIC OF CHINA

Johannesburg
LOS ANGELES

BAGHDAD

BEIJING
BEI

SEOUL
MEXICO CITY

•Resolve any epidemics

24

•Discard to 7 cards

DELHI
KARACHI

TOKYO
SAN
FRANCISCO

BOGOT

25

SHANGHAI
KOLKATA
HONG
KONG
BANGKOK

MUMBAI

KHARTOUM Sample
KHARTOU

BOGOT á

MIAM

23

1.Do 4 actions
2.Draw 2 cards

12
AIRO
STARTING CAIRO
CITY:
13
I
RIYADH
1
LAGOS
2 actions, plus 1 Drive/Ferry,
in any order

MEXICO CITY

SYDNEY
• Escape
22

3.Infect cities

ALGIERS

MIAMI

LOS ANGELES

SHANGHAI

Y

ISTANBUL
UL

11

MA NIL A

NE
SYD

Buenos
Aires
TEHRAN
EHRAN

Santiago

C

Istanbul C

São
Paulo

MOSCOW

MILAN

10

I

Lima

FINAL SIZE MARKS

TOKYO

ATLANTA

Cairo

ESSEN

26
14
27
15

OSAKA
TAIPEI

LIMA
ST. PETERSBURG

ESSEN

Actions
Notation
Hidden Actions
2
16
CHENNAI
• Infect Locally
The• Drive/Ferry
next player, however, entersAtlanta
Istanbul with
an action left. The
MANILA
MILAN
SANTIAGO
HO CHI 17
CHICAGO thatMONTRÉAL
Bio-Terrorist
he isAtlanta
spotted
hisairport
pawn
• Infect Remotely
•3Direct Flightannounces
Announce
MINHon
CITY
NEW and
YORK places
PARIS
KINSHASA
SAN
FRANCISCO
Istanbul.
The
player then Captures
him. The Bio-Terrorist
discards • Sabotage
Announce airport
• Charter
Flight
Atlanta
4
18
ISTANBUL
his•Istanbul
Draw Cardcard and gives this player
D his pawn. JAKARTA
If Captured
MADRID
WASHINGTON
5
19• Draw Card
Skipped
Action
LONDON

SAN
FRA NCIS CO

TOKYO

MA NIL A

LIMA
S ã O PAULO

ATLANTA
TLANTA

6
BUENOS AIRES
SANTIAGO

7

SYD

ALGIERS

MEXICO CITY

JOHANNESBURG

NEY

8

MEXICO

E

LOS ANGELES

9

• Escape

20

CAIRO

21

MIAMI

MEXICO CITY

D

BAG

LO S S
LE
AN GE

SYDNEY

221.Do 4 actions
LAGOS

E Mexico City Los Angeles
BOGOT á

2.Draw 2 cards

KHARTO

233.Infect cities

•Resolve any epidemics
•Discard to 7 cards

24KINSHASA
On10
his turn, the Bio-Terrorist draws Mexico City and Escapes,
discarding
Mexico City and announcing an airport sighting there. 25
11
He takes back his pawnLIMA
and then Drives to Los Angeles.
S ã O PAULO His plans
to 12
create an outbreak in Istanbul foiled, he heads towards Seoul... 26
13

BUENOS AIRES

JOHANNESBURG

27

SANTIAGO

2 actions, plus 1 Drive/Ferry, in any order

Actions
• Drive/Ferry
• Direct Flight
• Charter Flight
• Draw Card

Skipped Action

Sample Notation

Atlanta
Atlanta
Atlanta
D

Hidden Actions

7

• Infect Locally
Announce airport

• Infect Remotely

Announce airport

• Sabotage

If Captured
• Draw Card
• Escape

ROLES
BIO-TERRORIST

BIO-TERRORIST

FIELD OPERATIVE

The Field Operative may, once per turn as an action,
move 1 disease cube from the city he is in and place
it as a sample on his role card.

The Bio-Terrorist is used only in the Bio-Terrorist
challenge (see page 5).
Use only in the Bio-Terrorist Challenge.

• Once per turn, as an action, you may
move 1 disease cube from the city you are
in onto this Role card.
• When you Discover a Cure, you may
replace 2 of the needed City cards with 3
cubes of the cure color from this card.

After each player turn, do up to 2 actions,
plus 1 Drive/Ferry action (in any order).

ARCHIVIST

ARCHIVIST
The Archivist’s hand limit is 8 cards. He may, once per
turn, as an action, draw the City card that matches the
city he is in from the Player Discard Pile into his hand.

FIELD OPERATIVE

When he Discovers a Cure, he may replace exactly 2
of the needed City cards by returning 3 cubes of the
cure color from his Role card to the supply.

The Field Operative may return sample cubes from his role card
back to the supply at any time (see Event Cards timing,
Pandemic rules, page 7).

• Your hand limit is 8 cards.
• Once per turn, as an action, you may
take the City card that matches the city
you are in from the Player Discard Pile
into your hand.

GENERALIST

GENERALIST
The Generalist may do up to 5 actions each turn.

Players may not freely discard cards (for the Archivist to retrieve);
they may discard only by doing an action requiring a discard or
when over their hand limits.

CONTAINMENT
SPECIALIST

CONTAINMENT SPECIALIST
When the Containment Specialist enters a city,
if 2 or more disease cubes of the same color are
present, he removes 1 of them.

• When you enter a city with 2 or more
disease cubes of the same color,
remove 1 of them.

• Once during your turn, you may
(with permission) take any City card
from a player in the same city with
you. Doing this is not an action.

TROUBLESHOOTER

• Start your turn by looking at as many
Infection cards as the current infection
rate.
• When you do a Direct Flight, reveal the
City card used (but do not discard it).

He does this when moved by others (the Dispatcher or the Events
Airlift and Special Orders). If several diseases with 2 or more cubes
are present, he removes 1 cube from each of these diseases.

EPIDEMIOLOGIST

• You may do up to 5 actions each turn.

EPIDEMIOLOGIST
The Epidemiologist, once per turn and on her turn
(only), may take any City card from a player in the
same city. The other player must agree. Doing this is
not an action.

TROUBLESHOOTER
The Troubleshooter, at the start of her turn, looks at as
many Infection cards as the current infection rate (by
taking them from the top of the Infection Deck, looking at
them, and putting them back in the same order).

In the Mutation challenge, if the Troubleshooter sees a Mutation card,
she does not get to look at the bottom Infection Deck card.

When moving to a city via a Direct Flight, the Troubleshooter reveals the City
card used to the other players (but does not discard it). She may do this
when moving other pawns via the Event Special Orders, but not when being
moved by other players.

CREDITS
Game design: Matt Leacock and Tom Lehmann
Artwork: Chris Quilliams
Development: Team Z-Man Games
Playtesters: Jim Boyce, David Cortright, Barry Eynon, Chris and Kim Farrell,
Jay Heyman, Dave Helmbold, Wei-Hwa Huang, Trisha Lantznester, Donna
Leacock, Chris Lopez, Ron Sapolsky, Don Woods, and Michelle Zentis.
Special thanks to: Tom Lehmann, Scott di Bartolo, Wei-Cheng Cheng, Eric
Herman, Christian Kuntz, Brian Lee, Jeremy Moritz, Kwanchai Moriya, Kima
Pesan, Jack Reda, Ole Steiness, Isaiah Tanenbaum, and, for tireless
proof-reading, Wei-Hwa Huang.
Learn the rules online at:
www.zmangames.com/on-the-brink-online-rules.htm
© 2013 Z-Man Games, Inc.
3250 F.X. Tessier, Vaudreuil-Dorion,
Québec, Canada, J7V 5V5

8

[email protected]
www.zmangames.com

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