The Flu Shot Caused Flu Pandemic and Created More Flu in Canada

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Flu shot linked to higher incidence of flu in pandemic year - Health - CBC News

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Flu shot linked to higher incidence of flu in pandemic year
Vaccine-related phenomenon during pandemic once deemed a 'Canadian problem'
The Canadian Press Posted: Sep 10, 2012 8:11 AM ET Last Updated: Sep 10, 2012 12:55 PM ET 46

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New Canadian research backs suggestions that only people given a flu shot for the 2008-2009 season seemed to be more likely to get infected with the pandemic virus. (Jeff McIntosh/Canadian Press)

A strange vaccine-related phenomenon spotted at the start of the 2009 flu pandemic may well have been real, a new study suggests. Canadian researchers noticed in the early weeks of the pandemic that people who got a Flu shot flu shot for the 2008-2009 winter seemed to be phenomenon 2:44 more likely to get infected with the pandemic virus than people who hadn't received a flu shot. Five studies done in several provinces showed the same puzzling and unsettling results. But initially, research outside Canada did not, and the effect was dismissed as "the Canadian problem." News of the unexpected findings broke at a time when countries in North America and parts of Europe were getting ready to start vaccinating their populations against the pandemic virus. Some jurisdictions were also trying to figure out whether to offer the seasonal flu vaccine they had purchased — similar to the 2008-2009 shot — along with the pandemic vaccine, in case the seasonal flu viruses continued to circulate. Quebec opted not to offer the seasonal vaccine because of the concerns raised by the studies.

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http://www.cbc.ca/news/health/story/2012/09/10/flu-shot-pandemic.html[9/11/2012 9:26:25 AM]

Flu shot linked to higher incidence of flu in pandemic year - Health - CBC News

New Canadian research
Many people in the flu research and public health communities found the whole event unhelpful, and many rejected the findings. Some suggested if there was a problem, it might have been with the flu vaccine used in Canada, because the problem wasn't seen elsewhere. But a new study suggests the findings may indeed have been real. A group of Canadian researchers recreated the event in ferrets, the best animal model for predicting how influenza will act in humans. They worked with animals because it would have been unethical to subject people to the health risks the work entailed. The findings of the ferret study were presented Sunday at ICAAC, a major international infectious diseases conference taking place this year in San Francisco. (ICAAC stands for the Interscience Conference on Antimicrobial Agents and Chemotherapy.) Lead author Dr. Danuta Skowronski outlined the work at a webcast press conference. Skowronski, an influenza expert at the B.C. Centre for Disease Control in Vancouver, also led the first study that spotted the apparent interaction between 2008 flu shots and pandemic flu infection. B.C. to require flu protection for health workers She and her colleagues worked with 32 ferrets, giving half the 2008 seasonal flu shot and the remainder a placebo injection. The work was blinded, meaning the researchers didn't know which ferrets received which shot. Later, all the ferrets were infected with the pandemic H1N1 virus. The ferrets in the vaccine group became significantly sicker than the other animals, though all recovered. "The findings that we show are consistent with the increased risk that we saw in the human studies," Skowronski said. She said that in the time since the pandemic, researchers in other countries have reported a similar interaction. The reason for the effect is unclear, and Skowronski urged other research groups to take up the question. She said it is important to get to the root of what happened, before the next pandemic. But in the meantime, Skowronski insisted the findings should not deter people from getting seasonal flu shots. "I do think it's important to clarify that our findings are unique to the pandemic," she insisted. "Pandemics are infrequent occurrences, but seasonal influenza recurs on an annual basis. It's a substantial cause of morbidity and mortality," — science's term for illness and death — "and the seasonal vaccine substantially protects against that severe outcome due to seasonal influenza."
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Competing theories
Two theories exist about what might have been behind the effect, said Skowronski, who favours the first. That theory relates to the fact that the 2008 vaccine protected against an H1N1 virus that was related to — but not similar enough to — the pandemic virus to generate antibodies that would neutralize it. The thinking is that might actually have facilitated infection with the pandemic virus. Universal vaccine could eliminate annual flu shots Skowronski likened the mechanism to what happens with dengue

http://www.cbc.ca/news/health/story/2012/09/10/flu-shot-pandemic.html[9/11/2012 9:26:25 AM]

Flu shot linked to higher incidence of flu in pandemic year - Health - CBC News

viruses. People who have been infected with one subtype of dengue don't develop immunity to the other three. In fact, they are more at risk of developing a life-threatening form of dengue if they are infected with one of the other strains. Skowronski called the second theory the infection block hypothesis. Having a bout of the flu gives the infected person antibodies that may be able, for a time, to fend off other strains; flu shots only protect against the strains they contain. So under this theory, people who didn't have flu in 2008 because they got a flu shot may have been less well armed against the pandemic virus. If the first theory is right, the strange effect seen in 2009 might only occur in a pandemic in which the new virus was related to a circulating human flu virus, Skowronski admitted. If that's correct — and she stressed it's only a theory — a virus with a hemagglutinin protein that humans haven't been exposed to before might not trigger this type of phenomenon. (The hemagglutinin is the protein on the exterior of a flu virus that gives it the H number in its name.) "My own opinion, my own feeling would be that if you have a completely different hemagglutinin like H5 or H7 ... you may not see that," Skowronski said. "But who knows, frankly? The wise man knows he knows nothing when it comes to influenza, so you always have to be cautious in speculating."
© The Canadian Press, 2012

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adam60
2012/09/10 at 11:05 AM ET

This flu shot was never about our health, it was all about filling the pockets of the pharmaceutical industry. If you do your research you will find that this was the only benefit of the vaccine program during the H1N1 hype

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InedibleKiwi
2012/09/10 at 11:21 AM ET

I'd like to see the numbers of people who get the flu, even though they had their flu shot. Compare that to the number of people who get sick, without getting the flu shot. I think the numbers would be pretty surprising. For now, I'll keep doing my best to live a healthy life, and not rely on untrustworthy pharmaceuticals.

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mcshane
2012/09/10

She and her colleagues worked with 32 ferrets, giving half the 2008 seasonal flu shot and the remainder a placebo injection.

http://www.cbc.ca/news/health/story/2012/09/10/flu-shot-pandemic.html[9/11/2012 9:26:25 AM]

Flu shot linked to higher incidence of flu in pandemic year - Health - CBC News
at 7:21 AM ET

The ferrets in the vaccine group became significantly sicker than the other animals... Yet...

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Skowronski insisted the findings should not deter people from getting seasonal flu shots.

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Prmnitdumpbaby
2012/09/10 at 10:18 AM ET

If you are healthy you don't need the flu shot...

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casskar
2012/09/10 at 10:53 AM ET

To me this article just speaks volumes in relation to the H1N1 vaccine...they rushed that stuff through quickly, without enough testing..heck half way through all the inoculations they changed who should get it....I wondered too if it wasn't going to come back and kick people in the butt...and it looks as if it did, if I understand this article.

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Flu shot linked to higher incidence of flu in pandemic year - Health - CBC News
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