Useful Peptides
Peptides are the long molecular chains that make up proteins. Synthetic peptides are used either as drugs or in the diagnosis of disease. http://www.gallusimmunotech.com
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Useful Peptides
Peptides are the long molecular chains that make up proteins. Synthetic peptides are used either as drugs or in the diagnosis of disease. Peptides are difficult to make as the synthetic chemist must ensure that the amino acids which are added to the chain are in the correct order and that they don’t undergo any other reactions. This involves adding one amino acid, washing away any un-reacted acid then adding the next and so on. As can be imagined, this is very time consuming and only gives low yields. Peptides play an integral role in fundamental physiological and biochemical processes and are extremely essential to various aspects of biochemical research. This is especially important as the pharmaceutical industry continues to shift more towards biologists for new drug candidates. Custom peptide synthesis is continually a growing area of chemical biology research. Liquid phase peptide synthesis is a classical approach to peptide synthesis although it has been replaced in most labs by solid-phase synthesis. However, it still retains its usefulness in large-scale production of peptides for industrial purposes. Solid- phase peptide synthesis is now the accepted method for creating peptides and proteins in the lab in a synthetic manner. It allows the synthesis of natural peptides, which are difficult to express in bacteria, the incorporation of unnatural amino-acids, peptide/protein backbone modification, and the synthesis of D-proteins, which consist of D-amino acids. A synthetic custom peptide synthesis is an important tool in drug discovery and proteomic research. There are two main uses of synthetic peptides: Peptide drugs: Peptide drugs are either naturally occurring peptides or altered natural peptides. If a patient does not naturally produce the peptide that they need, this peptide can be synthesized and given to them. In addition, the amino acids in an active peptide can be altered to make analogues of the original peptide. Contraceptives have been made by synthesizing the antagonists of fertility peptides. Diagnostic peptides: Peptides can be designed that change color under certain conditions, and these can then be used for diagnostic purposes. For instance, a chromogenic peptide substrate can readily detect the presence, absence and varying blood levels of enzymes that control blood pressure and blood clotting ability.
http://www.gallusimmunotech.com
Peptides are the long molecular chains that make up proteins. Synthetic peptides are used either as drugs or in the diagnosis of disease. Peptides are difficult to make as the synthetic chemist must ensure that the amino acids which are added to the chain are in the correct order and that they don’t undergo any other reactions. This involves adding one amino acid, washing away any un-reacted acid then adding the next and so on. As can be imagined, this is very time consuming and only gives low yields. Peptides play an integral role in fundamental physiological and biochemical processes and are extremely essential to various aspects of biochemical research. This is especially important as the pharmaceutical industry continues to shift more towards biologists for new drug candidates. Custom peptide synthesis is continually a growing area of chemical biology research. Liquid phase peptide synthesis is a classical approach to peptide synthesis although it has been replaced in most labs by solid-phase synthesis. However, it still retains its usefulness in large-scale production of peptides for industrial purposes. Solid- phase peptide synthesis is now the accepted method for creating peptides and proteins in the lab in a synthetic manner. It allows the synthesis of natural peptides, which are difficult to express in bacteria, the incorporation of unnatural amino-acids, peptide/protein backbone modification, and the synthesis of D-proteins, which consist of D-amino acids. A synthetic custom peptide synthesis is an important tool in drug discovery and proteomic research. There are two main uses of synthetic peptides: Peptide drugs: Peptide drugs are either naturally occurring peptides or altered natural peptides. If a patient does not naturally produce the peptide that they need, this peptide can be synthesized and given to them. In addition, the amino acids in an active peptide can be altered to make analogues of the original peptide. Contraceptives have been made by synthesizing the antagonists of fertility peptides. Diagnostic peptides: Peptides can be designed that change color under certain conditions, and these can then be used for diagnostic purposes. For instance, a chromogenic peptide substrate can readily detect the presence, absence and varying blood levels of enzymes that control blood pressure and blood clotting ability.
http://www.gallusimmunotech.com
