William Allan Kritsonis, PhD

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William Allan Kritsonis, PhD - Selected National Refereed Journal Articles. Manuscript published earned five (5) affirmative votes from the National Editorial Review Board and was formally recommended for publication by the National Policy Board representing the respective journal. www.nationalforum.com

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The Lamar University Electronic Journal of Student Research Summer 2007

Dr. Izabella Rajzer
Faculty of Material Science and Ceramics AGH University of Science and Technology Cracow, Poland

Kimberly Grantham Griffith, PhD
Associate Professor and Faculty Mentor Lamar University Department of Professional Pedagogy College of Education and Human Development

William Allan Kritsonis, PhD
Professor and Faculty Mentor PhD Program in Educational Leadership Prairie View A&M University Member of the Texas A&M University System Visiting Lecturer (2005) Oxford Round Table University of Oxford, Oxford, England Distinguished Alumnus (2004) Central Washington University College of Education and Professional Studies Ellensburg, Washington

ABSTRACT This is a brief summary of a doctoral dissertation for the degree of Doctor of Engineering. The date of the dissertation defence was 6 October 2006. The degree was granted by the Faculty of Material Science and Ceramics, AGH University of Science and Technology, Cracow, Poland. Note: Special note of gratitude to Dr. Kimberly Grantham Griffith and Dr. William Allan Kritsonis for their assistance in getting the summary published in the United States of America. See: www.nationalforum.com ___________________________________________________________________________

Dissertation Title: Investigations into the use of fibrous carbon-based materials as scaffold for tissue engineering by Izabella Rajzer
The aim of the work was to investigate carbon fibrous materials as scaffold for tissue regeneration. By using carbon fibrous materials modification with new nanotechnology methods we can obtain fibers with specific biological properties. The work consisted of two parts. The first one was related to the designing and preparation of carbon fibrous materials. The effect of their chemical and physical modifications is presented. Composite carbon fibers were obtained by the temperature treatment of the nanocomposites organic fibers precursor. By combining PAN (polyacrylonitrile) fibers with active ceramic fillers, new original materials for scaffold applications can be manufactured. The second group of materials were prepared in the form of three dimensional fibrous structures made from fibers differing in diameters and porosity (micro- and nano- pores). These materials constituted a 3D scaffold containing fibrous components mimiting the structure brought about by natural tissue. The second part of thesis described the biological results of the obtained materials. Composite carbon fibers and porous carbon fibers were examined in the in vitro and in vivo studies. Cytotoxicity was determined according to ISO 10 993 standards, with the use of the human lung adenocarcinoma cells line A549. Material biocompatibility was determined by culturing human osteoblast-like cells of the line MG63 in contact with composite materials. Moreover, selected materials were examined in the vivo study. Samples prepared in the form of slides were examined by means of a set of histological and histochemical methods. To estimate the effect of the implants on the metabolic state of surrounding tissues, the activities of the following metabolic marker enzymes were examined: cytochrome c oxidase, NADH dehydrogenase and glucose-6-phosphate dehydrogenase. A study of the degradation product of carbon materials was also made. The proposed method of modification of carbon fibres described in this thesis allows us to obtain new materials with desired biological properties. The biological study provides us with new information about cell - carbon material interfacing.

See: www.nationalforum.com

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